CD36 is identified as the membrane receptor for cellular uptake of PROTACs and other eRo5/bRo5 molecules. A chemical endocytic medicinal chemistry strategy to enhance the binding of PROTACs to CD36 improved the uptake and potency of PROTACs without sacrificing solubility or stability. This strategy could improve the bioavailability and potency of diverse endocytic drugs.
The 2024 WHO BPPL is a key tool for prioritising research and development investments and informing global public health policies to combat AMR. Gram-negative bacteria and rifampicin-resistant M tuberculosis remain critical priority pathogens, underscoring their persistent threat and the limitations of the current antibacterial pipeline. Focused efforts and sustained investments in novel antibacterials are needed to address AMR priority pathogens, which include high-burden antibiotic-resistant bacteria such as Salmonella and Shigella spp, N gonorrhoeae, and S aureus.
KAIST’s breakthrough in colon cancer uses BENEIN to target MYB, HDAC2, FOXA2—offering a potential cure without chemo. A new era in South Korea cancer treatment.
Living to 100 may sound like a dream, but thanks to advancements in anti-aging and longevity research, it’s becoming more of a realistic goal than ever before. While genetics play a role, experts say your daily habits have a major impact on how gracefully—and healthfully—you age. From diet and movement to mindset and skincare, there are key lifestyle shifts and science-backed secrets that can help slow the aging process, boost vitality, and support a longer, more vibrant life.
Robert Love, a neuroscientist, shared three anti-aging and longevity secrets you should know about if you want to “slow down aging” and “even help reverse aging.” According to him, prioritizing sleep, avoiding ultra-processed foods, and taking healthy supplements are some of the best options. Read on to learn more.
Prioritizing sleep is one of the most powerful (and underrated) anti-aging tools you have. During deep sleep, your body goes into repair mode—producing growth hormone, regenerating cells, and fixing damage caused by stress and environmental factors. This nightly “reset” helps keep your skin, organs, and even brain functioning optimally.
In their study, published in Mechanobiology in Medicine, the researchers discovered that the protein responsible for binding neural stem cells in the human brain, neuro-cadherin, also plays a key role in stimulating their differentiation.
Neural stem cells are early-stage, unspecialized cells that have the ability to differentiate, or develop, into various types of neurons and non-neuronal cells of the central nervous system.
Researchers are closer to growing chicken nuggets in the lab, thanks to the use of tiny hollow fibers that mimic blood vessels.
While cultured meat has been advancing for some time now, it’s been limited to thin strips of less than a millimeter. Creating a thicker product with a familiar appeal has so far proven elusive.
“Replicating the texture and taste of whole-cut meat remains difficult,” explains biomedical engineer Shoji Takeuchi from The University of Tokyo.