Lifeboat Foundation

In this premier episode of Lifespan News, Brent Nally discusses Unity Biotechnology’s human trials of novel senolytic drugs, including a Phase 2 human trial of a senolytic drug for knee osteoarthritis; two proteins that allow LDL cholesterol to enter our cells; Ponce de Leon Health and epigenetic age reversal; the reason why naked mole rats are so resistant to cancer; XPrize adding longevity to its impact roadmaps; and a promo code for Ending Age-Related Diseases 2020, our upcoming online conference.

You can get your ticket to EARD2020 at https://www.eventbrite.com/e/ending-age-related-diseases-202…4918805703

Continue reading “Lifespan.io Launches Lifespan News” »

New research, based on earlier results in mice, suggests that our brains are never at rest, even when we are not learning anything about the world around us.

Our brains are often likened to computers, with learned skills and memories stored in the activity patterns of billions of nerve cells. However, new research shows that memories of specific events and experiences may never settle down. Instead, the activity patterns that store information can continually change, even when we are not learning anything new.

Why does this not cause the brain to forget what it has learned? The study, from the University of Cambridge, Harvard Medical School and Stanford University, reveals how the brain can reliably access stored information despite drastic changes in the brain signals that represent it.

Researchers from the Max Delbrück Center for Molecular Medicine have developed a new tool that makes it easier to maximize the power of deep learning for studying genomics. They describe the new approach, Janggu, in the journal Nature Communications.

Imagine that before you could make dinner, you first had to rebuild the kitchen, specifically designed for each recipe. You’d spend way more time on preparation, than actually cooking. For computational biologists, it’s been a similar time-consuming process for analyzing genomics data. Before they can even begin their analysis, they spend a lot of valuable time formatting and preparing huge data sets to feed into deep learning models.

To streamline this process, researchers from MDC developed a universal programming tool that converts a wide variety of genomics data into the required format for analysis by deep learning models. “Before, you ended up wasting a lot of time on the technical aspect, rather than focusing on the biological question you were trying to answer,” says Dr. Wolfgang Kopp, a scientist in the Bioinformatics and Omics Data Science research group at MDC’s Berlin Institute of Medical Systems Biology (BIMSB), and first author of the paper. “With Janggu, we are aiming to relieve some of that technical burden and make it accessible to as many people as possible.”

The amygdala is the brain’s surveillance hub: involved in recognizing when someone with an angry face and hostile body language gets closer, tamping down alarm when a honeybee buzzes past, and paying attention when your mother teaches you how to cross the street safely and points out which direction traffic will be coming from — in other words, things people should run away from, but also those they should look toward, attend to and remember.

In that sense, researchers say, this little knot of brain tissue shows just how tangled up emotion and social behavior are for humans. “Important events tend to be emotional in nature,” as do most aspects of social behavior, says John Herrington, assistant professor of psychiatry at the Children’s Hospital of Philadelphia in Pennsylvania.

As a result, the amygdala has long been a focus of autism research, but its exact role in the condition is still unclear.

Cheap paper and pencil-based medical wearables could one day replace expensive health monitors.

Singapore has just begun to get its second wave of coronavirus under control. Now, it’s on track to face its worst-ever outbreak of another viral infection: dengue.

More than 14,000 dengue cases have been reported in the city-state since the start of the year, according to the National Environment Agency (NEA). The total number for the whole year is expected to exceed the 22,170 cases reported in 2013 — the largest dengue outbreak in Singapore’s history, the agency said.

Dengue is a viral infection transmitted by the Aedes mosquito, the same insect responsible for spreading Zika, chikungunya and yellow fever. It is commonly found in hot, wet regions of the tropics and subtropics during the rainy months.

Can we learn from Isaac Newton?

With neither older scholars to guide him nor modern media distractions, student Isaac Newton came up with his most amazing works while sheltering from the plague.

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It’s not yet clear why some people infected with SARS-CoV-2, the virus that causes COVID-19, get really sick, while others have only mild symptoms. There’s some evidence that chronic health conditions—such as hypertension and diabetes can play a role, and scientists know that people’s genes can influence how their bodies react to other viruses. In a preprint posted to medRxiv on June 2, researchers describe a genome-wide association study (GWAS) of from 1,610 hospitalized patients with COVID-19 and 2,205 healthy controls. The authors identified variants in two regions—the locus that encodes blood type and a multi-gene cluster on chromosome 3—that were linked to respiratory failure during SARS-CoV-2 infection.

In a genome-wide association study, variants in both the ABO blood group locus and a cluster of genes on human chromosome 3 are more common among COVID-19 patients with respiratory failure than in the general population.

Continue reading “Two Genetic Regions Linked with Severe COVID-19” »

The first reliable way of isolating sperm stem cells from the testes and growing them outside the body could help infertile men have genetic children of their own.

A few teams have claimed to have isolated sperm stem cells before, but haven’t been able to repeat the results. “The general feeling is that there is no reliable method,” says Miles Wilkinson at the University of California, San Diego.