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Category: biotech/medical – Page 1,438

How 3D Printing Can Help in Your Medical Device Manufacturing Project

The subtractive manufacturing process involves etching, drilling, or cutting from a solid board to build the final product. It is ideal for applications using a wide variety of materials and in the PCB fabrication of large-size products. In the additive manufacturing process, a product is developed by adding material one layer at a time and bonding the layers together until the final product is ready. The ability to control material density and the possibility of including intricate features makes this process versatile. It is used in a range of engineering and manufacturing applications, especially in custom manufacturing.

Benefits of 3D printing in medical device manufacturing.

3D printing is economical and offers quick PCB prototyping without the need for complex manufacturing steps. It optimizes the PCB design process by avoiding possible design faults in the initial PCB design stages. 3D printing is easy on flex PCBs and multilayer PCB printing is possible using the latest design software. With the growing manufacturing trends and improving software, 3D printing will be more than a prototyping tool and can be a viable alternative for production parts. 3D printing has been recently used for the end-part manufacturing of several medical devices like hearing aids, dental implants, and more. It is more beneficial for low-volume productions.

DNA Repair Kit Successfully Fixes Hereditary Disease in Cells

Genetic mutations which cause a debilitating hereditary kidney disease affecting children and young adults have been fixed in patient-derived kidney cells using a potentially game-changing DNA repair-kit. The advance, developed by University of Bristol scientists, is published in Nucleic Acids Research.

In this new study, the international team describe how they created a DNA repair vehicle to genetically fix faulty podocin, a common genetic cause of inheritable Steroid Resistant Nephrotic Syndrome (SRNS).

Podocin is a protein normally located on the surface of specialised kidney cells and is essential for kidney function. Faulty podocin, however, remains stuck inside the cell and never makes it to the surface, terminally damaging the podocytes. Since the disease cannot be cured with medications, gene therapy which repairs the genetic mutations causing the faulty podocin offers hope for patients.

Better parks, cleaner rivers: How Pa. will spend a ‘generational’ $765 million for conservation and environmental programs

Under the state budget passed last week, Pennsylvania’s conservation programs will receive a one-time, pandemic-related federal booster shot of $765 million for state parks, forests, streams, open space, farms, and home energy efficiency — an amount one environmental advocate called “generational.”

The funding means three new state parks, one possibly in the Philadelphia region, as well as a new ATV park, though locations haven’t been announced. The money, which is in addition to regular yearly budget funding, comes from the American Rescue Plan Act (ARPA), a $1.9 trillion federal economic stimulus bill signed by President Joe Biden last year as part of COVID-19 relief.

The ARPA funds, combined with an additional $56 million from the state’s Oil and Gas Lease Fund, and a $12 billion state surplus, mean that agencies routinely faced with declining or stagnant spending plans are suddenly getting a big lift.

AI Imagines the Last Selfies on Earth in Grisly Yet Stunningly Delightful Frames

So, Artificial intelligence predicts selfies would dominate, ghoulish humans, holding mobiles, at the end of the earth, an event that would destroy every sign of life. Indeed, it is hypothetical and difficult to imagine the situation. An AI image generator, Midjourney, an obscure but close associate of Open AI, imagined a few of them revealing how scary they can be. Shared by a tik-tok account, @Robot Overloads, the images were hellish in tone and gory in substance. The images generated depict disfigured human beings with eyes as big as rat holes and fingers long enough to scoop out curdled blood from creatures of another world. These frames artificial intelligence has generated go beyond the portrayal of annihilation. Firstly, they are cut off from reality, and secondly, they are very few. The end of the world is billion years away when selfies would become a fossilized concept and humans are considered biological ancestors of cyborgs.

The pictures are stunning though in the sense that the elements like huge explosions going off in the background while a man maniacally staring into the camera are included in one frame. The imaginative spark of artificial intelligence should really be appreciated here. Perhaps it must have taken a hint or two from images of people taking selfies in the backdrop of accidents and natural calamities, to use them as click baits. Apparently, image generators give the users the power to visualize their imagination, how much ever removed from reality. However, the netizens are finding them captivating pleasantly, so much so that one of them wonders if they are from nibiru or planet X theories!! That one tik-tok video has got more than 12.7 million views and the reply, “OK no more sleeping,” posted by a Tik Tok user summarises, more than anything, the superficiality of melodramatic AI’s image generating capability.

Scientists identify hair loss regulator protein, could be reversible

Researchers at the University of California Riverside (UC Riverside) have identified a single protein that seems to control when hair follicles die. Armed with this new information, it might eventually be possible to reverse the process and stimulate hair regrowth.

The protein in question is known as TGF-beta, a signaling protein that regulates the division, growth and death of cells. As such, it plays major roles in important jobs like wound healing, and seems to be hijacked by cancer cells to allow uncontrolled growth. In this case, the team found that TGF-beta extends its work to the cells inside hair follicles.

“TGF-beta has two opposite roles,” said Qixuan Wang, co-author of the study. “It helps activate some hair follicle cells to produce new life, and later, it helps orchestrate apoptosis, the process of cell death.”

Blood Test #4 in 2022: Supplements, Diet

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Scientists Discover a Massacre: “Assassin” Cells Murder Innocent Cells

A process that involves the “murder” of living, newly-generated cells has been discovered for the first time in recent research conducted at the University of Haifa. The research, which was described in the esteemed journal Science Advances, discovered that throughout the cellular differentiation process in fruit flies, phagocytic cells consume and destroy healthy living cells.

“We found that phagocytes can function as ‘murderers.’ It is well-known that phagocytic cells swallow and dissolve dead cells, but we show for the first time that they also kill newly-created normal cells. Essentially we have characterized a new mechanism of cell death. The more we know the mechanisms of cell death, the better we understand how to cope with various diseases, particularly cancer”, explained Professor Hilla Toledano, head of the Department of Human Biology at the University of Haifa and author of the study.

The origin of several bodily tissues, including skin, hair, stomach, and testicles, may be traced back to stem cells. By continuously supplying new cells to replace the old ones, these powerful stem cells enable tissue replenishment. Each stem cell in this process splits into two cells, one of which is retained for use in the future and the other of which develops to take the place of the lost cell in the tissue.

Deep neural networks constrained by neural mass models improve electrophysiological source imaging of spatiotemporal brain dynamics

Many efforts have been made to image the spatiotemporal electrical activity of the brain with the purpose of mapping its function and dysfunction as well as aiding the management of brain disorders. Here, we propose a non-conventional deep learning–based source imaging framework (DeepSIF) that provides robust and precise spatiotemporal estimates of underlying brain dynamics from noninvasive high-density electroencephalography (EEG) recordings. DeepSIF employs synthetic training data generated by biophysical models capable of modeling mesoscale brain dynamics. The rich characteristics of underlying brain sources are embedded in the realistic training data and implicitly learned by DeepSIF networks, avoiding complications associated with explicitly formulating and tuning priors in an optimization problem, as often is the case in conventional source imaging approaches. The performance of DeepSIF is evaluated by 1) a series of numerical experiments, 2) imaging sensory and cognitive brain responses in a total of 20 healthy subjects from three public datasets, and 3) rigorously validating DeepSIF’s capability in identifying epileptogenic regions in a cohort of 20 drug-resistant epilepsy patients by comparing DeepSIF results with invasive measurements and surgical resection outcomes. DeepSIF demonstrates robust and excellent performance, producing results that are concordant with common neuroscience knowledge about sensory and cognitive information processing as well as clinical findings about the location and extent of the epileptogenic tissue and outperforming conventional source imaging methods. The DeepSIF method, as a data-driven imaging framework, enables efficient and effective high-resolution functional imaging of spatiotemporal brain dynamics, suggesting its wide applicability and value to neuroscience research and clinical applications.

Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults

In an ancillary study of the Vitamin D and Omega-3 Trial (VITAL), we tested whether supplemental vitamin D3 would result in a lower risk of fractures than placebo. VITAL was a two-by-two factorial, randomized, controlled trial that investigated whether supplemental vitamin D3 (2000 IU per day), n−3 fatty acids (1 g per day), or both would prevent cancer and cardiovascular disease in men 50 years of age or older and women 55 years of age or older in the United States. Participants were not recruited on the basis of vitamin D deficiency, low bone mass, or osteoporosis. Incident fractures were reported by participants on annual questionnaires and adjudicated by centralized medical-record review. The primary end points were incident total, nonvertebral, and hip fractures. Proportional-hazards models were used to estimate the treatment effect in intention-to-treat analyses.

Among 25,871 participants (50.6% women [13,085 of 25,871] and 20.2% Black [5106 of 25,304]), we confirmed 1991 incident fractures in 1,551 participants over a median follow-up of 5.3 years. Supplemental vitamin D3, as compared with placebo, did not have a significant effect on total fractures (which occurred in 769 of 12,927 participants in the vitamin D group and in 782 of 12,944 participants in the placebo group; hazard ratio, 0.98; 95% confidence interval [CI], 0.89 to 1.08; P=0.70), nonvertebral fractures (hazard ratio, 0.97; 95% CI, 0.87 to 1.07; P=0.50), or hip fractures (hazard ratio, 1.01; 95% CI, 0.70 to 1.47; P=0.96). There was no modification of the treatment effect according to baseline characteristics, including age, sex, race or ethnic group, body-mass index, or serum 25-hydroxyvitamin D levels. There were no substantial between-group differences in adverse events as assessed in the parent trial.

Vitamin D3 supplementation did not result in a significantly lower risk of fractures than placebo among generally healthy midlife and older adults who were not selected for vitamin D deficiency, low bone mass, or osteoporosis. (Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases; VITAL ClinicalTrials.gov number, NCT01704859.)

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