Lifeboat Foundation

In 2003, history was made. For the first time, the human genome was sequenced. Since then, technological improvements have enabled tweaks, adjustments, and additions, making the human genome the most accurate and complete vertebrate genome ever sequenced.

Nevertheless, some gaps remain — including human chromosomes. We have a pretty good grasp of them in general, but there are still some gaps in the sequences. Now, for the first time, geneticists have closed some of those gaps, giving us the first complete, gap-free, end-to-end (or telomere-to-telomere) sequence of a human X chromosome.

The accomplishment was enabled by a new technique called nanopore sequencing, which enables ultra-long-reads of DNA strands, providing a more complete and sequential assembly.

Ivanka Trump, a woman with a lifetime career guarantee and a net worth equalling the GDP of a small African country, has a plan for the millions of unemployed workers, many of whom lost their jobs during the pandemic: “Find Something New.” The initiative, in partnership with the nonprofit Ad Council, Tim Cook, and IBM executive chairman Ginni Rometty, sounds like the familiar Obama-era “learn to code” trope and not exactly on-brand with the Make American Great Again promise of told Ivanka to take her own advice.

In this premier episode of Lifespan News, Brent Nally discusses Unity Biotechnology’s human trials of novel senolytic drugs, including a Phase 2 human trial of a senolytic drug for knee osteoarthritis; two proteins that allow LDL cholesterol to enter our cells; Ponce de Leon Health and epigenetic age reversal; the reason why naked mole rats are so resistant to cancer; XPrize adding longevity to its impact roadmaps; and a promo code for Ending Age-Related Diseases 2020, our upcoming online conference.

You can get your ticket to EARD2020 at https://www.eventbrite.com/e/ending-age-related-diseases-202…4918805703

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New research, based on earlier results in mice, suggests that our brains are never at rest, even when we are not learning anything about the world around us.

Our brains are often likened to computers, with learned skills and memories stored in the activity patterns of billions of nerve cells. However, new research shows that memories of specific events and experiences may never settle down. Instead, the activity patterns that store information can continually change, even when we are not learning anything new.

Why does this not cause the brain to forget what it has learned? The study, from the University of Cambridge, Harvard Medical School and Stanford University, reveals how the brain can reliably access stored information despite drastic changes in the brain signals that represent it.

Researchers from the Max Delbrück Center for Molecular Medicine have developed a new tool that makes it easier to maximize the power of deep learning for studying genomics. They describe the new approach, Janggu, in the journal Nature Communications.

Imagine that before you could make dinner, you first had to rebuild the kitchen, specifically designed for each recipe. You’d spend way more time on preparation, than actually cooking. For computational biologists, it’s been a similar time-consuming process for analyzing genomics data. Before they can even begin their analysis, they spend a lot of valuable time formatting and preparing huge data sets to feed into deep learning models.

To streamline this process, researchers from MDC developed a universal programming tool that converts a wide variety of genomics data into the required format for analysis by deep learning models. “Before, you ended up wasting a lot of time on the technical aspect, rather than focusing on the biological question you were trying to answer,” says Dr. Wolfgang Kopp, a scientist in the Bioinformatics and Omics Data Science research group at MDC’s Berlin Institute of Medical Systems Biology (BIMSB), and first author of the paper. “With Janggu, we are aiming to relieve some of that technical burden and make it accessible to as many people as possible.”

The amygdala is the brain’s surveillance hub: involved in recognizing when someone with an angry face and hostile body language gets closer, tamping down alarm when a honeybee buzzes past, and paying attention when your mother teaches you how to cross the street safely and points out which direction traffic will be coming from — in other words, things people should run away from, but also those they should look toward, attend to and remember.

In that sense, researchers say, this little knot of brain tissue shows just how tangled up emotion and social behavior are for humans. “Important events tend to be emotional in nature,” as do most aspects of social behavior, says John Herrington, assistant professor of psychiatry at the Children’s Hospital of Philadelphia in Pennsylvania.

As a result, the amygdala has long been a focus of autism research, but its exact role in the condition is still unclear.

Cheap paper and pencil-based medical wearables could one day replace expensive health monitors.

Singapore has just begun to get its second wave of coronavirus under control. Now, it’s on track to face its worst-ever outbreak of another viral infection: dengue.

More than 14,000 dengue cases have been reported in the city-state since the start of the year, according to the National Environment Agency (NEA). The total number for the whole year is expected to exceed the 22,170 cases reported in 2013 — the largest dengue outbreak in Singapore’s history, the agency said.

Dengue is a viral infection transmitted by the Aedes mosquito, the same insect responsible for spreading Zika, chikungunya and yellow fever. It is commonly found in hot, wet regions of the tropics and subtropics during the rainy months.

Can we learn from Isaac Newton?

With neither older scholars to guide him nor modern media distractions, student Isaac Newton came up with his most amazing works while sheltering from the plague.