Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 1,444

Researchers find link between genetic mutations and cancer treatment resistance

Researchers from the University of Michigan Rogel Cancer Center, studying the molecular landscape of over 500 patients with an aggressive form of multiple myeloma, discovered a prevalence of activated key oncogenic pathways in these patients, much more than previously thought. Upwards of 45–65% of NF-κB and RAS/MAPK pathways each had alterations. The study was published in Nature Communications.

Further, Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology, and his team found a link between mutations and RASopathies, a certain group of genetic syndromes, in patients with relapsed treatment-resistant . This was the first observation of its kind.

The team compared the molecular makeup of patients with untreated multiple myeloma to those with the relapsed treatment-resistant version of the disease. Comparing these patients allowed researchers to describe drivers of the more aggressive form of multiple myeloma.

Researchers confirm brain region’s role in mind-body communication

University of Iowa researchers have confirmed in a new study that a specific region in the brain is critical to governing the mind’s communication with the body’s motor control system. The findings could yield advances in treatment for Parkinson’s disease, as declining motor coordination is a central symptom of the disorder.

In experiments with humans, the researchers pinpointed the as the region in the that communicates with the motor system to help the body stop an action. This communication is vital because it helps humans avoid surprises and react to potentially dangerous or unforeseen circumstances.

The subthalamic nucleus is a tiny grouping of cells that is part of the , which is a key circuit in controlling movement. The basal ganglia takes initial motor commands generated in the brain and either amplify or halt specific parts of those commands as they pass from the central nervous system to the spinal cord.

Brain.space remakes the EEG for our modern world (and soon, off-world)

Figuring out what’s going on in the brain is generally considered to be somewhere between extremely difficult and impossible. One major challenge is that the best ways to do so are room-sized machines relegated to hospitals — but brain.space is hoping that its portable, powerful and, most importantly, user-friendly EEG helmet could power new applications and treatments at home and, as a sort of cork pop for its debut, in space.

Electroencephalography, or EEG, is an established method for monitoring certain signals the brain produces. An EEG can indicate which areas of the cortex are active, whether the user is concentrating, agitated, and so on. It’s not nearly as precise as an MRI, but all you need for an EEG is a set of electrical contacts on the scalp, while an MRI machine is huge, loud and incredibly expensive.

There’s been precious little advancement in EEG tech, though, and it’s often done more or less the same way it was done decades ago. Recently, that’s begun to change with devices like Cognixion’s, which uses re-engineered EEG to interpret specific signals with the goal of allowing people with motor impairments to communicate.

AC/DC power supplies continue to shrink

Whether the AC/DC power supplies are open-frame or enclosed models or even desktop adapters, the latest power devices for medical and industrial applications share a few things in common: They offer a smaller solution size and achieve a higher power density while providing higher efficiency.

In addition, you’ll find that many power supply manufacturers are rolling out flexible and more options to meet the wide range of medical and industrial applications. Cooling and the capability to parallel power supplies are also important factors. Not surprisingly, these AC/DC power supplies also meet a variety of safety approvals and can operate in harsh environments.

Here is a selection of AC/DC power supplies that meet medical and industrial power requirements. In some cases, they meet requirements for both market segments.

SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial

Additional outpatient therapies which are readily accessible will be essential to reduce COVID-19 illness progression in high risk individuals. Especially as the virus continues to mutate with greater transmissibility despite increased global vaccination.

Use of NONS in patients recently infected with SARS-CoV-2 accelerates nasal virus clearance.

Funding provided by Glenmark Pharmaceuticals Limited. Study medication provided by SaNOtize.

Ever heard about bio-weapons that use DNA to kill specific person? They are reality now

A U.S. House Intelligence Committee member cautioned that bioweapons using a target’s DNA to kill only that individual are being created. US Representative Jason Crow of Colorado spoke on Friday at the Aspen Security Forum and cautioned Americans not to be too careless about sharing their DNA with private firms due to the impending arrival of the new type of weapon. “You can target a biological weapon that will kill that person or take them off the battlefield or make them inoperable,” Crow said. “You can take someone’s DNA, you know, take their medical profile,” he added.

Given the prevalence of DNA testing services, where customers voluntarily share their genetic mapping with companies to learn more about their ancestry and health, the congressman said it is concerning that these weapons are being developed. Although 23andMe has maintained time and time again that it does not sell its customers’ private information, it is one of many DNA companies that have done so when asked by the police.

As a member of the Senate Armed Services Committee, US Senator Joni Ernst of Iowa claimed that the US’s adversaries may deploy such DNA bioweapons to attack food supply on a large scale. Ernst forewarned that specific animals relied upon by civilians, armies, or towns could be the target of biological weapons, resulting in scarcity and food poverty and weakening populations.

Three Ways Nanotechnology Is Changing The Healthcare Industry

Antoine Galand, Director of Technology, GraphWear

Nanotechnology was once the stuff of science fiction, but today the concept of creating devices and machines that are several thousand times smaller than the width of a human hair is a well-established fact. The rise of nanotechnology has already transformed industries ranging from consumer electronics to textile manufacturing and cosmetics by unlocking new materials and processes at the nanoscale. The device you’re reading this on, for example, is only possible because of techniques adopted in the semiconductor industry that enable us to pattern silicon and metals to create the microscopic circuits and switches that are at the heart of modern computers.

One of the most promising applications of our newfound ability to manipulate individual atoms and molecules is in healthcare, where the ability of doctors to treat disease has been hamstrung by relatively blunt “macro” solutions. The human body is a remarkably complex system where, fundamentally, nanoscale processes occurring inside cells are what determine whether we are sick or healthy. If we’re ever going to cure diseases like diabetes, cancer or Alzheimer’s, we need technologies that work at their scale. Although medical nanotechnologies are relatively new, they’re already impacting the way we diagnose, treat and prevent a broad range of diseases.

Why 536 was ‘the worst year to be alive’

Ask medieval historian Michael McCormick what year was the worst to be alive, and he’s got an answer: “536.” Not 1,349, when the Black Death wiped out half of Europe. Not 1918, when the flu killed 50 million to 100 million people, mostly young adults. But 536. In Europe, “It was the beginning of one of the worst periods to be alive, if not the worst year,” says McCormick, a historian and archaeologist who chairs the Harvard University Initiative for the Science of the Human Past.

A mysterious fog plunged Europe, the Middle East, and parts of Asia into darkness, day and night—for 18 months. “For the sun gave forth its light without brightness, like the moon, during the whole year,” wrote Byzantine historian Procopius. Temperatures in the summer of 536 fell 1.5°C to 2.5°C, initiating the coldest decade in the past 2,300 years. Snow fell that summer in China; crops failed; people starved. The Irish chronicles record “a failure of bread from the years 536–539.” Then, in 541, bubonic plague struck the Roman port of Pelusium, in Egypt. What came to be called the Plague of Justinian spread rapidly, wiping out one-third to one-half of the population of the eastern Roman Empire and hastening its collapse, McCormick says.

Historians have long known that the middle of the sixth century was a dark hour in what used to be called the Dark Ages, but the source of the mysterious clouds has long been a puzzle. Now, an ultraprecise analysis of ice from a Swiss glacier by a team led by McCormick and glaciologist Paul Mayewski at the Climate Change Institute of The University of Maine (UM) in Orono has fingered a culprit. At a workshop at Harvard this week, the team reported that a cataclysmic volcanic eruption in Iceland spewed ash across the Northern Hemisphere early in 536. Two other massive eruptions followed, in 540 and 547. The repeated blows, followed by plague, plunged Europe into economic stagnation that lasted until 640, when another signal in the ice—a spike in airborne lead—marks a resurgence of silver mining, as the team reports in this week.

‘Watershed moment’: Doctors finding new hope in treatments for deadly pancreatic cancer

Correction & clarification: A prior version of this story contained inaccurate information. Pancreatic cancer is poised to pass colon cancer as the second deadliest tumor type.

Barbara Brigham was having a very bad 2020.

Her 97-year-old mother, whom she’d cared for years, died in January. Her husband, who’d suffered the ill effects of Agent Orange since his tours of duty in Vietnam, died of cancer in June. In September, she was diagnosed with pancreatic cancer, which has a five-year survival rate of only around 10%.

/* */