A unprecedented global study of Alzheimer’s disease has uncovered an additional 42 genes that may affect a person’s risk of developing the disorder. Doctors hope to use that information to develop a more precise way to identify risk.
Category: biotech/medical – Page 1,407
Age of skin cells reversed by 30 years
The researchers looked at multiple measures of cellular age. First, they used the epigenetic clock, where chemical tags throughout the genome indicate age. Secondly, they looked at the transcriptome, all the gene readouts produced by the cell. By these two measures, the reprogrammed cells matched the profile of cells that were 30 years younger, compared to reference data sets. In other words, cells from a woman of 53 now appeared like those of a woman aged 23.
The potential applications of this technique are dependent on cells not only appearing younger, but functioning like young cells too. Fibroblasts produce collagen – a molecule found in bones, skin tendons, and ligaments, helping provide structure to tissues and heal wounds. In this study, the rejuvenated fibroblasts produced more collagen proteins compared to control cells that did not undergo the reprogramming process. Fibroblasts also move into areas that need repairing. Researchers tested the partially rejuvenated cells by creating an artificial cut in a layer of cells in a dish, seen in the video below. The treated fibroblasts moved into the gap faster than older cells. This is a promising sign that one day this research could eventually be used to create cells that are better at healing wounds.
In the future, this research may also open up other therapeutic possibilities; the researchers observed that their method also influenced other genes linked to age-related diseases and symptoms. The APBA2 gene – associated with Alzheimer’s, and the MAF gene with a role in the development of cataracts – both showed changes towards youthful levels of transcription.
Complete sequence of human genome published in landmark achievement
Dr. Karen Miga, a co-lead of the T2T consortium and professor at the University of California, Santa Cruz, told Medical News Today, “The availability of a complete genome sequence will advance our understanding of the most difficult-to-sequence and repeat-rich parts of the human genome.”
“In the future, when someone has their genome sequenced, researchers and clinicians will be able to identify all of the variants in their DNA and use that information to better guide their healthcare. Knowing the complete sequence of the human genome will provide a comprehensive framework for scientists to study human genomic variation, disease, and evolution.”
Reversal of time? Scientists de-age human skin cells by 30 years in trial
In a new trial conducted by the University of Cambridge, scientists were successfully able to de-age human skin cells by 30 years.
With age, the ability of cells to function properly declines. As a result, the NDA blueprint of people starts to accumulate signs of aging.
Researchers have used regenerative biology to create ‘’induced’’ stem cells and produce fibroblasts that generates collagens that heal wounds and provide structure to tissues.
New anti-aging research enables human cells to “time jump” 30 years
A team of researchers have found a way to “time jump” cells back 30 years. A team of researchers at the Babraham Institute, a partner organization of the University of Cambridge, UK, have made a breakthrough in regenerative medicine. Just published in the journal eLife, the team shows how they managed to turn back the clock 30 years for human skin cells.
A new regenerative medicine technique has been developed that can make old human cells 30 years younger without losing specialization.
Dr. Peter J. Hotez — Baylor College of Medicine — Scientist, Researcher, Author, Science Explainer
Coming off multiple country approvals for his “patent free” Covid vaccine, Scientist, Researcher, Author, Science Explainer, Dr. Peter Hotez, MD, Ph.D. Baylor College of Medicine, drops by for an episode of Progress, Potential, And Possibilities.
Dr. Peter J. Hotez, M.D., Ph.D. (https://peterhotez.org/), is Dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology and Microbiology at Baylor College of Medicine (https://www.bcm.edu/people-search/peter-hotez-23229), where he is also Chief of the Section of Pediatric Tropical Medicine and the Texas Children’s Hospital Endowed Chair of Tropical Pediatrics (https://www.texaschildrens.org/find-a-doctor/peter-jay-hotez-md-phd).
Dr. Hotez is also Rice University’s Baker Institute fellow in disease and poverty (https://www.bakerinstitute.org/experts/peter-j-hotez/) and Co-Director of Parasites Without Borders (https://parasiteswithoutborders.com/), a global nonprofit organization with a focus on those suffering from parasitic diseases in subtropical environments.
Dr. Hotez is an internationally recognized physician-scientist with expertise in neglected tropical diseases and vaccine development. He leads the only product development partnership for developing new vaccines for hookworm, schistosomiasis and Chagas disease, and is just coming off a major win for emergency use approval of his team’s Corbevax protein sub-unit COVID-19 vaccine, of which he, and previous guest to the show, Dr. Maria Elena Bottazzi, were recently nominated for a Nobel Prize.
Dr. Hotez is the author of more than 400 original papers, as well as the books Forgotten People, Forgotten Diseases — The Neglected Tropical Diseases and Their Impact on Global Health and Development, Blue Marble Health — An Innovative Plan to Fight Diseases of the Poor amid Wealth, Vaccines Did Not Cause Rachel’s Autism: My Journey as a Vaccine Scientist, Pediatrician, and Autism Dad, and Preventing the Next Pandemic: Vaccine Diplomacy in a Time of Anti-science.
Michael Fossel | Aging: Understanding it, Reversing it
Dr Fossel talking about dementia, telomeres, and clarifying some experimental myths.
Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.
Program & apply to join: https://foresight.org/biotech-health-extension-program/
Michael Fossel, Telocyte.
Aging: Understanding it, Reversing it.
Michael Fossel is Founder and President of Telocyte. He served as the executive director of the American Aging Association, has published more than 100 articles, books, and chapters on age-related disease and the potential for effective intervention via gene therapy, as well as have served as both an advisor to and board member for several biotechnology companies prior to Telocyte.
Join us:
Humans could live up to 150 years, new study claims
Humans could live until the ripe old age of 150 years according to recent research – and scientists are racing to work out how.
Harvard geniuses, biohackers and internet billionaires are all looking for ways that humans can crack the code on aging.
WaitButWhy blogger Tim Urban writes “the human body seems programmed to shut itself down somewhere around the century mark, if it hasn’t already”.