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Category: biotech/medical – Page 128

Scientists accidentally discover DNA that breaks the rules of life

A routine experiment with a new single-cell DNA sequencing method turned into a surprising scientific twist when researchers stumbled upon a bizarre genetic code in a microscopic pond organism. Instead of following the near-universal “rules” of life, this newly identified protist rewrites how genes signal their end. This unexpected discovery challenges long-held assumptions about how genetic translation works and hints that nature may be far more flexible—and mysterious—than scientists realized.

New targeted radiopharmaceutical therapy induces remission in pancreatic cancer model

A newly developed targeted radiopharmaceutical treatment can effectively slow tumor growth in pancreatic ductal adenocarcinoma (PDAC), according to new research published in the May issue of The Journal of Nuclear Medicine. In preclinical models, the treatment achieved complete remission of the disease, highlighting its potential to transform care for this highly aggressive cancer.

PDAC accounts for more than 90% of pancreatic cancer cases and remains one of the most lethal malignancies, with a five-year survival rate of less than 5% in patients with metastatic disease. Although surgery is the only curative approach, it is feasible only in 10%–20% of patients with localized disease.

“PDAC is very difficult to treat, and new options are urgently needed,” said Marika Nestor, professor in the Department of Immunology, Genetics and Pathology at Uppsala University in Sweden. “Our previous findings suggest a possible new targeted treatment approach for pancreatic cancer patients whose tumors express CD44v6, which may help make treatment more precise and effective.”

Decoding intended speech with an intracortical brain-computer interface in a person with long-standing anarthria and locked-in syndrome

This study aimed to explore the alleviating effects of fisetin, a polyphenolic flavonoid, on ovarian dysfunction in a D-galactose (D-gal)-induced aging mouse model, as well as the underlying mechanisms, using both in vivo and in vitro experiments. Mice were subcutaneously injected with D-gal (100 mg/kg/day) for 60 days to establish the ovarian aging model; during the final 30 days, fisetin (10, 20, 30 mg/kg/day) was given orally. In addition, a senescent model of granulosa cell (GC) was established using D-gal and treated with fisetin. Fisetin supplementation improved ovarian endocrine function and reproductive capacity in aging mice, as reflected by regularized estrous cycles, elevated estradiol levels, and increased embryo numbers. Furthermore, fisetin reduced the number of atretic follicles and the extent of ovarian fibrosis and senescence, while simultaneously restoring the proliferation-apoptosis balance in follicular GCs, as well as alleviating oxidative stress. RNA-sequencing revealed that AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR) signaling and mitophagy were involved in the protective effects of fisetin against ovarian aging. Consistently, fisetin treatment promoted mitophagy, accompanied by AMPK/mTOR activation in ovarian tissues and GCs following D-gal exposure. Inhibition of AMPK attenuated the effect of fisetin on mitophagy. Additionally, blockage of mitophagy also reversed the beneficial effects of fisetin on mitochondrial injury, oxidative stress, cell cycle arrest, and cellular senescence in D-gal-induced senescent GCs. These findings indicate that fisetin prevents ovarian aging by suppressing follicular GC oxidative damage and ameliorating cell cycle arrest via activation of AMPK/mTOR-mediated mitophagy, thereby preserving female fertility.

MYH9 gene may help explain heart artery plaques more often seen in women

Researchers at UCLA Health have identified a key gene that may help explain why women are more likely than men to develop a certain type of artery plaque linked to heart disease.

In a study published in Circulation Research, investigators found that a gene known as MYH9 plays an important role in the formation of fibrous plaques. These buildups in the arteries are generally more stable than those more prone to rupture, but they can still lead to heart attacks and other serious cardiac events through plaque erosion.

Atherosclerosis, the buildup of plaque in the arteries, is the underlying cause of most heart disease. Research has mainly focused on unstable plaques, which can rupture and trigger heart attacks. Fibrous, scar-like plaques tend to have thicker caps and different biological characteristics.

Sleep Duration Linked to Accelerated Aging

The relationship between sleep and disease suggests that there exists a connection between the brain and the body that extends beyond merely influencing the brain itself.

Among brain-related disorders, short sleep was significantly associated with depressive episodes and anxiety disorders, as seen in other studies of sleep and mental health. Short sleep was also associated with obesity, type 2 diabetes, hypertension, ischemic heart disease, and heart arrhythmias.

Short and long sleep were associated with chronic obstructive pulmonary disease, asthma, and a cluster of digestive disorders, including gastritis and gastroesophageal reflux disease.

Giant squid discovery uncovers a hidden deep-sea world off Australia

Scientists exploring deep underwater canyons off the coast of Western Australia uncovered a hidden world packed with bizarre and elusive marine life — including signs of the legendary giant squid. By analyzing traces of DNA floating in seawater from depths exceeding 4 kilometers, researchers identified 226 species ranging from deep-diving whales to strange fish rarely or never seen in the region before. Some of the creatures may even be unknown to science.

Low-cost 3D printers could gain medical-grade precision from ultrathin light-control film

Researchers have developed an ultra-thin optical film that improves the quality of the light used in LCD resin-based 3D printers. The advance helps ensure that tiny details are reproduced with precision, which could make it possible to 3D-print medical-grade or industrial-grade products at a lower cost.

Resin-based 3D printing, or vat photopolymerization, uses short-wavelength light to project patterns onto liquid photosensitive resin. Although this additive manufacturing approach enables highly detailed, smooth parts, some low-cost systems rely on LCD backlights that can reduce printing accuracy.

“LCD-based liquid 3D printing suffers from surface roughness or dimensional inaccuracies due to improper light angular distribution from the backlight systems used,” said research team leader Ding-Zheng Lin from National Taiwan University of Science and Technology. “Our goal was to fix these problems without increasing equipment size, thereby elevating print performance to professional grade.”

Umbilical cord blood transplant with pooled stem cell product shows 96% survival and no GVHD in leukemia patients

A new way of using umbilical cord blood for treating blood diseases could make the treatment more accessible to patients who need a stem cell transplant. A Phase II clinical trial of patients undergoing a cord blood transplant plus a stem cell product derived from pooled cord blood units showed that 27 of 28 patients (96%) with leukemias and GVHD survived at least one year and none of the patients experienced severe acute or chronic graft-versus-host disease, which are common complications of stem cell transplantation.

The results have been published in the Journal of Clinical Oncology.

“This is the first time transplant patients received cells from what amounts to nine different human beings,” said the study’s principal investigator, Filippo Milano, MD, Ph.D., who is first author of the study and directs the Cord Blood Program at Fred Hutch Cancer Center.

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