In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusions were feasible and well tolerated with a median overall survival of 19.8 months and 3 patients surviving over 40 months from diagnosis.
As the rate of humanity’s data creation increases exponentially with the rise of AI, scientists have been interested in DNA as a way to store digital information. After all, DNA is nature’s way of storing data. It encodes genetic information and determines the blueprint of every living thing on earth.
And DNA is at least 1,000 times more compact than solid-state hard drives. To demonstrate just how compact, researchers have previously encoded all of Shakespeare’s 154 sonnets, 52 pages of Mozart’s music, and an episode of the Netflix show “Biohackers” into tiny amounts of DNA.
But these were research projects or media stunts. DNA data storage isn’t exactly mainstream yet, but it might be getting closer. Now you can buy what may be the first commercially available book written in DNA. Today, Asimov Press debuted an anthology of biotechnology essays and science fiction stories encoded in strands of DNA. For $60, you can get a physical copy of the book plus the nucleic acid version—a metal capsule filled with dried DNA.
What is cell senescence and inflammaging?
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Large language models surpass human experts in predicting neuroscience results, according to a study published in Nature Human Behaviour.
Scientific research is increasingly challenging due to the immense growth in published literature. Integrating noisy and voluminous findings to predict outcomes often exceeds human capacity. This investigation was motivated by the growing role of artificial intelligence in tasks such as protein folding and drug discovery, raising the question of whether LLMs could similarly enhance fields like neuroscience.
Xiaoliang Luo and colleagues developed BrainBench, a benchmark designed to test whether LLMs could predict the results of neuroscience studies more accurately than human experts. BrainBench included 200 test cases based on neuroscience research abstracts. Each test case consisted of two versions of the same abstract: one was the original, and the other had a modified result that changed the study’s conclusion but kept the rest of the abstract coherent. Participants—both LLMs and human experts—were tasked with identifying which version was correct.
Polygenic scores (PGS) are metrics used to estimate the genetic predisposition of people to developing specific mental health conditions, personality traits or diseases. In recent years, these metrics have often been used to investigate the intricate connections between genes and environmental factors.
Researchers at the JJ Peters VA Medical Center, Icahn School of Medicine at Mount Sinai and other institutes recently carried out a study aimed at determining whether neuropsychiatric polygenic scores could predict the professional categories that individuals belong to. Their findings, published in Nature Human Behaviour, suggest that these scores weakly predict the professional category that people belong to.
“Neuropsychiatric disorders are both common and highly heritable, yet they remain heavily stigmatized,” Georgios Voloudakis, first author of the paper, told Medical Xpress.
For the first time ever, scientists have used a technique called “quantum squeezing” to improve the gas sensing performance of devices known as optical frequency comb lasers. These ultra-precise sensors are like fingerprint scanners for molecules of gas. Scientists have used them to spot methane leaks in the air above oil and gas operations and signs of COVID-19 infections in breath samples from humans.
Now, in a series of lab experiments, researchers have laid out a path for making those kinds of measurements even more sensitive and faster—doubling the speed of frequency comb detectors. The work is a collaboration between Scott Diddams at CU Boulder Boulder and Jérôme Genest at Université Laval in Canada.
“Say you were in a situation where you needed to detect minute quantities of a dangerous gas leak in a factory setting,” said Diddams, professor in the Department of Electrical, Computer and Energy Engineering. “Requiring only 10 minutes versus 20 minutes can make a big difference in keeping people safe.”
Scientists develop DNADNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA). tabindex=0 DNA nanorobots capable of modifying artificial cells.
Leading A Government-Wide Response To Long COVID — Dr. Ian Simon, Ph.D. — Director, Office of Long COVID Research and Practice, Office of the Assistant Secretary for Health (OASH), U.S. Department of Health and Human Services (HHS)
Dr. Ian Simon, Ph.D. is the Director for the Office of Long COVID Research and Practice (https://www.hhs.gov/longcovid/index.html), in the Office of Science and Medicine, in the Office of the Assistant Secretary for Health at the U.S. Department of Health \& Human Services.
The Office of Science and Medicine harnesses the power of collaboration, scientific analysis, data-driven innovation, and emerging technologies for advancing initiatives across the Department, including not just Long COVID, but in the areas of behavioral health, health equity, kidney disease, infection-associated chronic conditions, mother-infant dyad, sickle cell disease, and traumatic brain injury.
Previously Dr. Simon was the Assistant Director for Health Strategy and Biopreparedness at the White House Office of Science and Technology Policy, where he led pandemic prevention and biosecurity policy priorities. Most recently, he was the Senior Advisor to the Director of NIH’s National Institute of Allergy and Infectious Diseases (NIAID).
Prior to working at NIAID, Dr. Simon was the Assistant Director of the Institute for Defense Analyses (IDA) Science and Technology Policy Institute. In that role, he specialized in developing policy initiatives including bioeconomy, STEM education, pandemic preparedness, biosecurity, and international S\&T cooperation.
“Proteins are the molecular machinery that helps the body to function — and malfunction. Their role in disease is crucial, but rarely simple. Knowing which are associated with a particular disease can help doctors and scientists to spot it earlier and narrow down potential treatments,” writes Tom Whipple in The Times, as he describes the potential impact of a new study from UK Biobank that is the world’s largest exploration of all the proteins in the human body.
Thermo Fisher’s Olink Proteomics Explore HT platform, which enables precise analysis of proteins in the human body, will play a key role in the work. Researchers will use our technology to study the role proteins play in many types of diseases. Their findings will fuel the discovery of new protein biomarkers that could predict, diagnose and treat diseases. The study “has the potential to transform healthcare by the end of this decade,” says Dr. Chris Whelan, who is leading a group of pharmaceutical companies working on the project.
‘Treasure trove’ of samples provided by UK volunteers has the potential to transform healthcare by the end of this decade, say scientists.
