Aging happens in distinct stages marked by synchronized cellular changes across organs, as shown in Rockefeller’s largest-ever mammalian aging atlas. Their findings offer clues for targeting aging processes and reveal key age and sex differences in cellular dynamics.
If you compared photos of a maple tree taken in July and December, the difference would be striking: a vibrant green canopy in summer versus bare, stark branches in winter. What those images wouldn’t reveal is how the transformation unfolded—whether it was gradual or sudden. In reality, deciduous trees usually wait for environmental cues, such as changes in light or temperature, before shedding all their leaves within a brief span of one to two weeks.
When it comes to aging, we may be more like these trees than we realized.
The Digital Brain platform is capable of simulating spiking neuronal networks at the neuronal scale of the human brain. The platform is used to reproduce blood-oxygen-level-dependent signals in both the resting state and action, thereby predicting the visual evaluation scores.
Aging is an inevitable aspect of life, but age-related diseases are not an inseparable part of the aging process, and their risk can be reduced through a healthy lifestyle. Vitamin K has a broader impact than just blood clotting, and yet it remains overshadowed by other vitamins and underestimated by both doctors and consumers. Vitamin K (VK) is a multifunctional micronutrient with anti-inflammatory and antioxidant properties, whose deficiency may cause age-related diseases such as cardiovascular diseases, neurodegenerative diseases and osteoporosis. There is a growing body of evidence supporting the role of vitamin K as a protective nutrient in aging and inflammation. This review summarizes the current knowledge regarding the molecular aspects of the protective role of vitamin K in aging and age-related diseases and its clinical implications.
An initially “unknown” illness affecting hundreds in the Democratic Republic of the Congo may be attributable to malaria, malnutrition and a viral infection. But investigations are ongoing.
In recent years, roboticists have developed a wide range of systems that could eventually be introduced in health care and assisted living facilities. These include both medical robots and robots designed to provide companionship or assistance to human users.
Researchers at Shanghai Jiao Tong University and the University of Shanghai for Science and Technology recently developed a robotic system that could give human users a massage that employs traditional Chinese medicine (TCM) techniques. This new robot, introduced in a paper on the arXiv preprint server, could eventually be deployed in health care, wellness and rehabilitation facilities as additional therapeutic tools for patients who are experiencing different types of pain or discomfort.
“We adopt an adaptive admittance control algorithm to optimize force and position control, ensuring safety and comfort,” wrote Yuan Xu, Kui Huang, Weichao Guo and Leyi Du in their paper. “The paper analyzes key TCM techniques from kinematic and dynamic perspectives and designs robotic systems to reproduce these massage techniques.”
Salt, or more precisely the sodium it contains, is very much a “Goldilocks” nutrient. Low sodium levels cause a drop in blood volume, which can have serious, sometimes deadly, health consequences. Conversely, too much salt can lead to high blood pressure and cardiovascular disease.
In modern America, where most people consume a high-salt diet, almost no one is in danger of having too little salt. However, given the critical importance of sodium for body and brain functions, evolution has developed a powerful drive to consume salt in situations where there is a deficiency.
Understanding the brain circuitry that controls salt appetite has proved elusive, but now a new study by University of Iowa researchers has identified the first and, thus far, only neurons necessary for salt appetite.
Patients with late-stage cancer often have to endure multiple rounds of different types of treatment, which can cause unwanted side effects and may not always help.
In hopes of expanding the treatment options for those patients, MIT researchers have designed tiny particles that can be implanted at a tumor site, where they deliver two types of therapy: heat and chemotherapy.
This approach could avoid the side effects that often occur when chemotherapy is given intravenously, and the synergistic effect of the two therapies may extend the patient’s lifespan longer than giving one treatment at a time. In a study of mice, the researchers showed that this therapy completely eliminated tumors in most of the animals and significantly prolonged their survival.
It’s getting harder to harder to ignore the potential disruptive power of AI in research. Scientists are already using AI tools but could the future lead to complete replacement of humans? How will our scientific institutions transform? These are difficult questions but ones we have to talk about in today’s episode.
Written, presented \& edited by Prof. David Kipping.
THANK-YOU to T. Widdowson, D. Smith, L. Sanborn, C. Bottaccini, D. Daughaday, S. Brownlee, E. West, T. Zajonc, A. De Vaal, M. Elliott, B. Daniluk, S. Vystoropskyi, S. Lee, Z. Danielson, C. Fitzgerald, C. Souter, M. Gillette, T. Jeffcoat, J. Rockett, D. Murphree, M. Sanford, T. Donkin, A. Schoen, K. Dabrowski, R. Ramezankhani, J. Armstrong, S. Marks, B. Smith, J. Kruger, S. Applegate, E. Zahnle, N. Gebben, J. Bergman, C. Macdonald, M. Hedlund, P. Kaup, W. Evans, N. Corwin, K. Howard, L. Deacon, G. Metts, R. Provost, G. Fullwood, N. De Haan, R. Williams, E. Garland, R. Lovely, A. Cornejo, D. Compos, F. Demopoulos, G. Bylinsky, J. Werner, S. Thayer, T. Edris, F. Blood, M. O’Brien, D. Lee, J. Sargent, M. Czirr, F. Krotzer, I. Williams, J. Sattler, B. Reese, O. Shabtay, X. Yao, S. Saverys, A. Nimmerjahn, C. Seay, D. Johnson, L. Cunningham, M. Morrow, M. Campbell, B. Devermont, Y. Muheim, A. Stark, C. Caminero, P. Borisoff, A. Donovan, H. Schiff, J. Cos, J. Oliver, B. Kite, C. Hansen, J. Shamp, R. Chaffee, A. Ortiz, B. McMillan, B. Cartmell, J. Bryant, J. Obioma, M. Zeiler, S. Murray, S. Patterson, C. Kennedy, G. Le Saint, W. Ruf, A. Kochkov, B. Langley, D. Ohman, P. Stevenson, T. Ford \& T. Tarrants.
Scientists have developed imaging-guided, biodegradable microrobots that can be propelled acoustically or magnetically through tissues for targeted drug delivery and enhanced ultrasound imaging contrast.
