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Category: biotech/medical – Page 1,000

Unraveling the Genetic Mechanisms Behind Long-Lasting Memories in the Brain

Summary: Researchers shed new light on the molecular and genetic basis of long-term memory formation in the brain. A new study reveals a single stimulation to the synapses of hippocampal neurons triggered numerous cycles where the memory-coding Arc gene produced mRNA molecules that were then translated into synapse-strengthening Arc proteins. From the findings, researchers determined a novel feedback loop that helps explain how short-lived mRNA and proteins create long-term memories in the brain.

Source: albert einstein college of medicine.

Helping your mother make pancakes when you were three…riding your bike without training wheels…your first romantic kiss: How do we retain vivid memories of long-ago events?

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Genetic Driver of Anxiety Discovered

Summary: An international team of scientists has identified a gene in the brain responsible for anxiety symptoms and found that modifying the gene can reduce anxiety levels, offering a novel drug target for anxiety disorders. The discovery highlights a new amygdala miR483-5p/Pgap2 pathway that regulates the brain’s response to stress and provides a potential therapeutic approach for anxiety disorders.

Source: University of Bristol.

A gene in the brain driving anxiety symptoms has been identified by an international team of scientists. Critically, modification of the gene is shown to reduce anxiety levels, offering an exciting novel drug target for anxiety disorders.

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Scientists Use Electricity to Make Wounds Heal 3x Faster

Scientists have developed a specially engineered biochip that uses electricity to heal wounds up to three times faster than normal.

It’s well known that electric fields can guide the movements of skin cells, nudging them towards the site of an injury for instance. In fact, the human body generates an electric field that does this naturally. So researchers from the University of Freiburg in Germany set out to amplify the effect.

While it might not heal severe injuries with the speed of a Marvel superhero, it could radically reduce the time it takes for small tears and lacerations to recover.

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Opinion letter from Ray Kurzweil on request for 6 month delay on large language models that go beyond GPT-4 « Kurzweil

Kurzweil says NO, on AI pause non sense.

By Ray Kurzweil April 2023

Regarding the Open Letter to “pause” research on AI “more powerful than GPT-4,” this criterion is too vague to be practical. And the proposal faces a serious coordination problem: those that agree to a pause may fall far behind corporations or nations that disagree. There are tremendous benefits to advancing AI in critical fields such as medicine and health, education, pursuit of renewable energy sources to replace fossil fuels, and scores of other fields. I didn’t sign, because I believe we can address the signers’ safety concerns in a more tailored way that doesn’t compromise these vital lines of research.

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New study reveals a gel that promises to wipe out brain cancer for good

An anti-cancer gel promises to wipe out glioblastoma permanently, a feat that’s never been accomplished by any drug or surgery. So what makes this gel so special?

Scientists at Johns Hopkins University (JHU) have developed a novel gel that both eliminates brain cancer (glioblastoma) and keeps it from recurring. When they tested this anti-cancer gel on mice with glioblastoma, surprisingly, all the mouse models were cured of the illness.

“We don’t usually see 100% survival in mouse models of this disease,” said Betty Tyler, one of the study authors and a neurosurgery professor at the Johns Hopkins School of Medicine.

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New ‘ear-EEG’ device could be used for early detection of neurodegenerative disorders

A new project called Progression Assessment in Neurodegenerative Disorders of Aging or PANDA aims to detect subtle changes in a person’s sleep patterns that may indicate the onset of Alzheimer’s or Parkinson’s disease. The collaboration of this four-year project involves Rigshospitalet University, Denmark’s Aarhus University, and MedTech company T&W Engineering. The project has received funding of DKK 15 million to develop and test a small earbud-like experimental device that can detect the early signs of these diseases.

The Ear-EEG Technology

Unlike the traditional sleep-monitoring systems that require a person to stay in a clinic with multiple electrodes attached to their body, the ear-EEG allows for comfortable, long-term use at home. The device monitors electrical activity in the brain by measuring tiny voltage changes on the skin surface within the ear canal. It is also equipped with an oximeter for measuring blood oxygen levels, a microphone for monitoring respiration and heart rate, and a thermometer for measuring body temperature.

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Bronchial Asthma as a Cardiovascular Risk Factor: A Prospective Observational Study

Introduction: Asthma as a chronic inflammatory disorder has been suggested as a risk factor for endothelial dysfunction (ED), but studies on the association between asthma and cardiovascular disease (CVD) risk are limited. Background: We assessed associations of ED with the severity of asthma, eosinophilic inflammation, lung function, and asthma control. Methods: 52 young asthmatics (median age of 25.22 years) and 45 healthy individuals were included. Demographic, clinical, and laboratory findings were recorded. We evaluated microvascular responsiveness by recording the reactive hyperemia index (RHI) indicating post-occlusive peripheral endothelium-dependent changes in vascular tone using the Itamar Medical EndoPAT2000. VCAM-1, ADMA, high-sensitive CRP (hsCRP), and E-selectin were measured. Results: Asthmatics had considerably lower RHI values (p < 0.001) with a dynamic decreasing trend by asthma severity and higher hsCRP levels (p < 0.001). A substantial increase in hsCRP and E-selectin with asthma severity (p < 0.05) was also observed. We confirmed a higher body mass index (BMI) in asthmatics (p < 0.001), especially in women and in severe asthma. Conclusions: We demonstrated the progression of CVD in asthmatics and the association of the ongoing deterioration of ED with the inflammatory severity, suggesting that the increased risk of CVD in young asthmatics is dependent on disease severity. The underlying mechanisms of risk factors for CVD and disease control require further study.

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