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Category: biotech/medical – Page 1,003

Mitochondrial research rewrites understanding of Parkinson’s disease pathway

While mitochondria play a crucial role in producing the energy our cells need to carry out their various functions, when damaged, they can have profound effects on cellular function and contribute to the development of various diseases.

Broken-down are usually removed and recycled through a garbage disposal process known as “mitophagy.”

PINK1 and Parkin are two proteins vital to this process, responsible for “tagging” malfunctioning mitochondria for destruction. In Parkinson’s disease, mutations in these proteins can result in the accumulation of damaged mitochondria in the brain, which can lead to motor symptoms such as tremors, stiffness and difficulty with movement.

Chemical imbalance in the forebrain underpins compulsive behavior and OCD, study reveals

Scientists at the University of Cambridge have used powerful new brain imaging techniques to reveal a neurochemical imbalance within regions of the frontal lobes in patients with obsessive-compulsive disorder (OCD). The research findings are published in the journal Nature Communications.

The study shows that the balance between glutamate and GABA—two major neurotransmitter chemicals—is “disrupted” in OCD patients in two frontal regions of the brain.

Researchers also found that people who do not have OCD but are prone to habitual and compulsive behavior have increased glutamate levels in one of these brain regions.

Reprogrammed skin cells become human placenta in new breakthrough

Prof. Yossi Buganim and his research team at the Faculty of Medicine at the Hebrew University of Jerusalem have achieved a groundbreaking milestone in the field of cell reprogramming. Their latest study, published in Nature Communications, reveals a remarkable breakthrough in converting skin samples into functional human placenta cells. This achievement has significant implications for understanding pregnancy development, studying pregnancy-related diseases, and advancing cell therapies.

The research opens new avenues for investigating the causes of infertility, complications during pregnancy, and long-term health implications for both mothers and babies.

Reprogramming cells to assume new identities has been a focus of Prof. Buganim’s lab, which utilizes specialized proteins to modify . By transforming skin cells into other , the team enables the study of specific diseases and the potential development of cell-based therapies. However, accessing cells from the placenta, a critical organ in pregnancy, has long been a challenge due to technical and ethical constraints.

MiNT protein a fresh target to attack disease

A two-faced protein in a chain that regulates iron and other elements in cells could provide a new target to treat cancer, diabetes and other diseases.

A team of researchers at Rice University, the University of California at San Diego (UCSD), the Hebrew University of Jerusalem and the University of North Texas detailed the structure of a protein called mitochondrial inner NEET (MiNT), part of a pathway that stabilizes mitochondria, the organelles that produce energy for cells.

Their report appears this week in the Proceedings of the National Academy of Sciences.

Accelerating Drug Discovery With the AI Behind ChatGPT — Screening 100 Million Compounds a Day

Huge libraries of drug compounds may hold potential treatments for a variety of diseases, such as cancer or heart disease. Ideally, scientists would like to experimentally test each of these compounds against all possible targets, but doing that kind of screen is prohibitively time-consuming.

In recent years, researchers have begun using computational methods to screen those libraries in hopes of speeding up drug discovery. However, many of those methods also take a long time, as most of them calculate each target protein’s three-dimensional structure from its amino-acid.

Quitting Smoking After Cancer Diagnosis Reduces Risk of Cardiovascular Events

Recent advances in cancer diagnosis, treatment, and management have resulted in a growing number of cancer survivors. Researchers constantly strive to understand new ways to support cancer survivors and help them lead a healthy and happy life post-treatment. This has led to our understanding that cancer survivors have different healthcare needs than their counterparts with no history of cancer.

One concern facing cancer survivors involves cardiovascular disease (CVD), a general term including conditions that inflict the heart or blood vessels. Many cancer survivors face a higher risk of dying from cardiovascular disease (CVD) than from cancer itself.

Despite the well-known adverse effects of tobacco use associated with both cancer and CVD, about 20% of cancer survivors continue smoking after diagnosis. How smoking cessation impacts CVD risk after cancer diagnosis remains poorly understood. To address this, a team of researchers recently published their study investigating the cardiovascular consequences of quitting smoking after a cancer diagnosis in the European Heart Journal.

China produces early-stage blood cells in space for the 1st time

During the experiment, pluripotent stem cells – a special kind of stem cells that have the potential to grow into all major human cells – were brought into the Wentian lab module on the space station, where some of them successfully grew into hematopoietic stem cells – another kind of stem cells that produce blood cells.

Dozens of other science experiments were also conducted by the Shenzhou-15 crew during their stay at the China Space Station.

A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics

Here we address the important question of cross-talk between the mitochondria and cytosol. We show that the inner mitochondrial protein, MiNT, interacts with a protein on the outer mitochondrial membrane (mNT). This interaction occurs within the major outer membrane protein VDAC1. Inside the inner space of VDAC1, MiNT transfers its [2Fe-2S] clusters to mNT, which was shown to be a [2Fe-2S] cluster donor protein that donates its cluster(s) to apo-acceptor proteins residing in the cytosol. Hence, we suggest a pathway for transferring [2Fe-2S] clusters from inside the mitochondria to the cytosol.

Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET (mNT) proteins belong to the NEET protein family. This family plays a key role in mitochondrial labile iron and reactive oxygen species (ROS) homeostasis. NEET proteins contain labile [2Fe-2S] clusters which can be transferred to apo-acceptor proteins. In eukaryotes, the biogenesis of [2Fe-2S] clusters occurs within the mitochondria by the iron–sulfur cluster (ISC) system; the clusters are then transferred to [2Fe-2S] proteins within the mitochondria or exported to cytosolic proteins and the cytosolic iron–sulfur cluster assembly (CIA) system. The last step of export of the [2Fe-2S] is not yet fully characterized. Here we show that MiNT interacts with voltage-dependent anion channel 1 (VDAC1), a major OMM protein that connects the intermembrane space with the cytosol and participates in regulating the levels of different ions including mitochondrial labile iron (mLI). We further show that VDAC1 is mediating the interaction between MiNT and mNT, in which MiNT transfers its [2Fe-2S] clusters from inside the mitochondria to mNT that is facing the cytosol. This MiNT–VDAC1–mNT interaction is shown both experimentally and by computational calculations. Additionally, we show that modifying MiNT expression in breast cancer cells affects the dynamics of mitochondrial structure and morphology, mitochondrial function, and breast cancer tumor growth. Our findings reveal a pathway for the transfer of [2Fe-2S] clusters, which are assembled inside the mitochondria, to the cytosol.

Malaria Just Spread in the US for the First Time in 2 Decades — Will There Be More Cases?

Malaria, a mosquito-borne infectious disease mostly found in tropical climates, is now on American shores. Late Monday, the Centers for Disease Control and Prevention announced a spat of cases — one in Texas and four in Florida — discovered in May and June that were locally acquired versus acquired while traveling abroad. This is the first time this has happened since 2003.

The CDC said that all five patients received treatment and are recovering, but the agency remains on alert for any new cases. While malaria was once a public health threat in the US, its presence was eradicated in the early 1950s. The last major outbreak was in 2003 with eight patients in Palm Beach County, Florida, all of whom had significant outdoor exposure.

For now, the CDC says the risk of catching malaria in the US “remains extremely low.” However, the instance shouldn’t be taken lightly, especially as many of us will be spending more time outdoors and traveling during the summer. Here’s what you need to know.