An important objective of medical research is to identify the underlying molecular mechanisms of human brain health and diseases.
This objective has been predominantly achieved through observational studies of gene expression in human brain tissues obtained from post-mortem brain donors for their analysis. Importantly, many of these studies are based on the assumption that gene expression in the post-mortem human brain is an exact representation of gene expression in the living human brain.
A recent study published on the medRxiv preprint server challenges this assumption by comparing human prefrontal cortex gene expression between living and post-mortem samples.
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