Hy3 is a 295B-parameter Mixture-of-Experts model from Tencent (21B active, 192 experts with top-8 routing) built for reasoning, agentic workflows, and real-world production use. It supports a configurable reasoning effort: a direct no-think mode by default, plus low and high chain-of-thought modes for complex math, coding, and multi-step problems. With a 256K context window, Hy3 targets long-horizon tasks, including improved coreference resolution, multi-turn constraint tracking, and stable tool-calling that generalizes across agent scaffoldings.
Tencent positions it as a reliable, cost-effective option across coding, document processing, financial analysis, game development, and frontend design, with a strong emphasis on grounded, anti-hallucination behavior that answers when grounded and flags when evidence is missing rather than fabricating.
In the aftermath of a devastating earthquake, unpiloted aerial vehicles (UAVs) could fly through a collapsed building to map the scene, giving rescuers information they need to quickly reach survivors.
But this remains an extremely challenging problem for an autonomous robot, which would need to swiftly adjust its trajectory to avoid sudden obstacles while staying on course.
Researchers from MIT and the University of Pennsylvania developed a new trajectory-planning system that tackles both challenges at once. Their technique enables a UAV to react to obstacles in milliseconds while staying on a smooth flight path that minimizes travel time.
Autophagy is the process by which cells remove damaged proteins, recycle worn-out organelles (e.g., mitochondria), clear cellular waste and provide nutrients during stress. Autophagy is essential for muscles because they are constantly under mechanical stress. If autophagy is too low, damaged proteins accumulate and muscle gradually weakens. If it is too high, muscle tissue can begin breaking itself down.
Disruption of autophagy has been implicated in a wide range of muscle disorders, and abnormal muscle autophagy is frequently observed in neurogenic diseases. However, the neuronal signaling pathways that control this process had previously remained largely unknown.
Now, researchers led by Prof. Zhang Hong from the Institute of Biophysics of the Chinese Academy of Sciences have identified two parallel neuronal circuits that regulate the autophagy-lysosome pathway in the body wall muscle of Caenorhabditis elegans, a tiny nematode worm. Their research has uncovered a previously unknown mechanism by which the worm’s nervous system maintains muscle homeostasis.
Genomic surveillance—the process of monitoring and sequencing pathogens—is one of the most important tools for detecting emerging viral threats. But global surveillance systems remain costly, unevenly distributed and often are too slow to identify dangerous variants before they spread internationally, amplifying future disease outbreak threats.
A recently published research paper in Nature Communications, co-authored by Dr. Patricia Ning, assistant statistics professor, and Jifan Li, a doctoral candidate in the Department of Statistics, along with collaborators from multiple international institutions, introduces a new framework to address these issues while using fewer resources, making genomic surveillance rapid and cost-effective in preparation for new strains of COVID-19.
Ning’s algorithm works to strengthen local, community-based surveillance capacity in all regions in anticipation of future pandemics.
A novel vaccination strategy against certain malignant brain tumors could fundamentally improve treatment for patients. Researchers from the German Cancer Research Center (DKFZ), Mannheim University Medical Center, Heidelberg University Hospital and numerous partner institutions have published encouraging long-term results from a clinical trial involving a vaccine that activates the immune system against a common genetic mutation in these tumors.
Gliomas are usually incurable brain tumors that are difficult to remove completely through surgery. Chemotherapy and radiation therapy are also effective only to a limited extent. These tumors often share a key characteristic: In most cases, the cancer cells carry a common genetic mutation. An identical genetic error causes a specific amino acid to be substituted in the IDH1 enzyme. This results in a novel protein structure—a so-called neoepitope. What makes this special is that the neoepitope drives tumor growth and, at the same time, is recognized as foreign by the patient’s immune system, making it an ideal target for immunotherapies.
The research team from Heidelberg/Mannheim and Tübingen developed a peptide vaccine that specifically trains the immune system to recognize and fight tumor cells with this mutation. The vaccine was tested for safety and efficacy in a phase 1 clinical trial (NOA 16) involving 33 patients with newly diagnosed high-grade astrocytomas, the most common form of glioma. The patients received the vaccine in addition to standard therapy consisting of surgery, radiation therapy and chemotherapy. The work is published in the journal Nature Cancer.
Aging changes gut bacteria in mice, weakening communication between the intestines and the brain. Restoring that connection helped older mice form memories as effectively as young mice.
Our brains are large compared with other animals, so it is tempting to assume there was an evolutionary advantage to them – but that may not be true at all
How will humanity power its interplanetary future? In this cinematic documentary, we journey to the year 2,325, where humanity has finally achieved Type I civilization status. We explore the colossal engineering feats required to harvest the Sun’s energy from Mercury and beam it across the entire solar system.
▶A Film by: Scienshell.
In a universe where energy is the currency of survival, the diffused sunlight that has bathed our solar system for 5 billion years is no longer enough. To fuel a true interplanetary empire, humanity must harvest, concentrate, and transmit the immense power of our star. But harnessing such staggering amounts of energy requires pushing the absolute limits of physics and engineering.
As our energy needs grow, the line between theoretical physics and applied engineering begins to blur. For those who build the infrastructure of tomorrow, the solar system itself becomes a machine.
In this video, you’ll discover: [00:00] Introduction. [01:29] 2325: The Dawn of a Type I Civilization. [02:15] Mining Mercury and the Solar Ring Construction. [06:24] Photons: The Perfect Interplanetary Energy Carriers. [08:12] The Beating Heart of the Energy Grid. [11:02] Precursor Beams and Cosmic No-Fly Zones. [13:01] The Danger of Runaway Gamma Beams. [15:12] The Gamma Cascade: Converting Destructive Energy. [17:34] Powering an Interplanetary Civilization.
What does humanity look like two thousand years into the future? In this cinematic 4K documentary, we embark on an extraordinary voyage to the year 4001. For over five centuries, star ships have departed from the third arm of the Milky Way galaxy, gradually piecing together a complete map of our cosmic neighborhood. From harvesting the energy of entire stars to exploring the unseen boundaries of higher dimensions, this is the blueprint of a civilization that has outgrown its cradle.
▶A Film by: Scienshell Studio.
What began as a fragile step into orbit has evolved into a grand interstellar federation. Guided by advanced computing minds and fueled by cosmic mega-structures, human intelligence now spreads across distant territories light-years away, flourishing under the light of alien suns.
In this video, you’ll discover: 00:00 Introduction. 02:26 The Grand Era of Space Exploration. 04:02 Dyson Power Station No. 22 06:18 The Mind: The Galactic Brain and Reversible Computing. 09:38 Gravitational Dams and Artificial Black Holes. 12:04 Antimatter Batteries and Space Travel. 13:13 The Oasis Rings and the Dinosaur Renaissance. 15:56 Project Asgard: Unlocking the extra Dimensions of Space.
▶ About This Video. Two millennia after our first steps into space, humanity has transformed from planetary inhabitants into cosmic architects. Through cinematic 3D visuals and detailed scientific narration, this film explores the reality of a Type II civilization: Dyson spheres draining entire stars for energy, gravitational dams capturing the mass of artificial black holes, and orbital evolutionary rings designed to replicate ancient Earth and trigger a prehistoric renaissance. Finally, we look at Project Asgard, an experiment tracking graviton escape to map the hidden nine dimensions of space.
This documentary is perfect for anyone fascinated by speculative future technology, Dyson spheres, advanced civilizations, black hole energy extraction, and the ultimate destiny of human exploration.
