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Artificial hibernation reveals synaptic engram architecture associated with memory retention

If individual synapses were the sole key to holding onto memories, this sudden structural “demolition” should have erased everything the mice learned. Remarkably, it didn’t. Once the mice woke up and recovered, their memories were completely intact.

The Power Clusters: The synapses connecting “memory-encoding” neurons (the specific cells storing the memory) weren’t randomly scattered. Instead, they were organized into tightly bound, spatially clustered groups. When hibernation wiped out standard synapses, the brain prioritized protecting these specialized clusters.

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Electric fields offer new hope against aggressive brain cancer

More than a decade ago, Dr. Matthew Hebb was treating patients with Parkinson’s disease using deep brain stimulation by implanting tiny electrodes into the brain and delivering electrical signals to control tremors. He wondered if the same basic technology could be used against brain cancer.

Hebb, a neurosurgery professor at Western University’s Schulich School of Medicine & Dentistry, took tumor samples removed during surgery back to his laboratory, implanted electrodes and stimulated the cancer cells. The tumors responded.

That unexpected observation set in motion years of research into what is now called Intratumoral Modulation Therapy, or IMT—an original approach that uses low-amplitude electric fields to disrupt the growth of glioblastoma, one of the most aggressive and difficult-to-treat brain cancers.

Scientists uncover ‘hidden switch’ that helps cancer cells hide from the immune system

Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have uncovered a previously unknown mechanism that helps cancer cells evade detection by the body’s immune system. The finding could pave the way for the development of more effective cancer immunotherapies.

Published in Science Immunology, the study identifies the RNA helicase DDX6 as a previously unrecognized “hidden switch” that prevents the immune system from recognizing cancer cells. Targeting DDX6 could make tumors more visible to the immune system, improving existing or new immunotherapies.

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