An array of genetically encoded tools are now available to label and manipulate synapses in different experimental species. Kaang and colleagues provide an overview of these techniques, highlighting their advantages, disadvantages and utility for investigating synaptic function.
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Quantifying postsynaptic receptor dynamics: insights into synaptic function
The molecular organization of the synapse is both highly organized and dynamic. Triller and colleagues outline advances in single-particle tracking technologies that have enabled us to gain quantitative insights into the mechanisms that regulate postsynaptic receptor dynamics.
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A computer that runs on living human neurons is currently playing Doom. It’s called CL1, built by Cortical Labs from brain cells grown in a lab. There’s no one at the controls, and yet something is clearly learning. What’s actually running this thing is the strange part, and it’s the reason I had to make this video.
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New tissue atlas aims to help AI understand cancer
How cells are arranged within tissue can reveal as much about disease as the cells themselves. When doctors examine a cancer tumor, for example, they don’t just look at which cells are present; they also want to know how those cells are arranged and how they interact with each other. That’s because the way cancer cells interact with neighboring immune cells can offer important clues about how a disease develops or responds to treatment.
Scientists can study these relationships using spatial proteomics, a technology that captures this organization by measuring dozens of proteins while preserving their locations. Because proteins help control what cells do, these images offer a valuable picture of how healthy and diseased tissues work.
But the resulting data sets are difficult to combine. Research laboratories around the world use different equipment, examine different proteins and store their results in different ways. Combining this information is complicated and time-consuming, making it difficult to use large amounts of data for both conventional studies and, now, training artificial intelligence.
What Scientists Found Beneath Antarctica Shouldn’t Still Exist
What is actually hidden beneath Antarctica’s ice?Scientists are creating the clearest maps yet of the landscape beneath Antarctica, revealing enormous mounta…
Peritumoral adipose tissue: A bidirectional regulator of cancer
This review synthesizes evidence that peritumoral adipose tissue and tumors dynamically reshape one another through metabolic, immune, and stromal interactions across cancer types. It highlights how this bidirectional crosstalk creates tumor-supportive niches and may reveal therapeutic opportunities for disrupting the adipose-tumor axis.
Cancer-Associated Adipocytes in the Tumor Microenvironment
These stimuli suppress adipogenic markers while activating pathways associated with inflammation, fibrosis, and extracellular matrix remodeling. As a result, CAAs acquire fibroblast-like features and contribute actively to tumor progression.
CAAs are most commonly found at the invasive front of tumors, where cancer cells interact directly with surrounding adipose tissue. This strategic localization allows CAAs to:
These moths smell with their wings
Never-before-seen ability may allow the insects to home in on their favorite plants
New Roles for the Cell’s Powerhouse Uncovered in Catalog of Mitochondria
A research consortium has generated a catalog of mitochondrial proteins across eukaryotic organisms, capturing the organelle’s diversity across the tree of life and revealing clues to its origin and role in the evolution of complex-celled organisms.
Radical New Tactic Would Stop Deadly Cancers Before They Start
Cancer interception clinical trials aim to prevent abnormal growths from developing into tumors by combining early detection and immunotherapy.