Han et al. identify VEGFR2 as a suppressor of cGAMP-STING signaling. Upon cGAMP stimulation, VEGFR2 is phosphorylated and suppresses STING activation via activating and recruiting AKT1. The VEGFR2 inhibitor Ki8751 relieves this repression and activates NF-κB signaling, further amplifying STING responses and the antitumor effect.
Jang et al. show that disruption of oral-gut microbial compartmentalization characterizes gastrointestinal cancers. By quantifying mouth-to-feces microbial transmission, they identify robust diagnostic signatures that accurately classify gastric and colorectal cancers across seven independent cohorts, highlighting a new non-invasive framework for microbiome-based cancer detection.
Boyer, Blaye et al. show that CD52-expressing immunosuppressive myeloid cells can shape breast tumor plasticity beyond immune evasion. They show that this myeloid subset delivers membrane-bound TGF-β1 via cell contact to generate mesenchymal-like cancer stem cells in luminal breast cancer, and TGF-β blockade prevents this stemness program.
What if the Borg discovered a way to travel beyond the boundaries of their universe?
Not faster warp.
Not another transwarp conduit.
But a doorway into infinite realities.
In this video, we explore one of the most terrifying possibilities in Star Trek: Why did the Borg never conquer the multiverse?
With their transwarp technology, adaptive intelligence, and endless hunger for perfection, the Borg seem uniquely positioned to expand beyond a single universe. Every reality could contain new civilizations to assimilate, unimaginable technologies to steal, and knowledge beyond anything the Collective has ever encountered.
Seven years after the original 2019 report, the reported 3.6 liters per hour per square meter remains an interesting benchmark for understanding the potential of solar purification research. The lasting value of the work is not simply the numerical comparison with commercial solar stills but the broader principle behind it: materials can be engineered to make renewable-energy technologies more productive.
Some of nature’s most important chemical reactions rely on the coupled movement of negatively and positively charged particles. These processes play central roles in photosynthesis, catalysis and biological energy conversion yet remain difficult to observe.
Now, a research team led by the Department of Energy’s Pacific Northwest National Laboratory, in collaboration with colleagues at SLAC National Accelerator Laboratory and several academic labs, has captured snapshots of these events triggered when light strikes a molecule.
The findings, published in Nature Communications, could help researchers better understand and ultimately design better flow batteries, fuel cells and catalysts.