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Serotonin signaling and gut-immune crosstalk: the microbiome’s role in antitumor immunity.

“…Serotonin transporter inhibits cytotoxic CD8-positive T lymphocyte antitumor immunity by depleting serotonin within the tumor microenvironment…”

“…Serotonin transporter-blocking selective serotonin reuptake inhibitor antidepressants enhance cytotoxic CD8-positive T lymphocyte antitumor immunity and act synergistically with programmed cell death protein 1 immune checkpoint blockade therapy…”

To this end, here…

“…Tumor-infiltrating cytotoxic CD8-positive T lymphocytes were identified as the primary producers and mediators of a local, immunomodulatory serotonin signaling pathway independent of the gastrointestinal tract…”

“…Upon recognition of tumor antigens, tumor-infiltrating cytotoxic CD8-positive T lymphocytes upregulate tryptophan hydroxylase 1, which synthesizes serotonin followed by its release into the tumor microenvironment to enhance T lymphocyte activation via serotonin signaling…”

In short…

Continue reading “Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis” | >

At Phobio, well-implemented AI hasn’t just made us faster—it’s made us sharper, more creative and more strategic. When routine tasks are streamlined, people have time to think deeply about customers, competition and innovation.

Closing Thoughts

AI isn’t coming to take your job. But someone who knows how to use it might.

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Using an algorithm they call the Krakencoder, researchers at Weill Cornell Medicine are a step closer to unraveling how the brain’s wiring supports the way we think and act. The study, published June 5 in Nature Methods, used imaging data from the Human Connectome Project to align neural activity with its underlying circuitry.

Mapping how the brain’s anatomical connections and activity patterns relate to behavior is crucial not only for understanding how the brain works generally but also for identifying biomarkers of disease, predicting outcomes in neurological disorders and designing personalized interventions.

The brain consists of a complex network of interconnected neurons whose collective activity drives our behavior. The structural connectome represents the physical wiring of the brain, the map of how different regions are anatomically connected.

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🔮 Step into a world of infinite possibilities with “The Maker of Universes” by Philip José Farmer—a groundbreaking science fiction novel that explores the boundaries of reality, mythology, and the human psyche across multiple universes. 🚀🌌 In this visionary tale, we follow the story of Robert Wolff, an Earthling who finds himself transported to the mysterious world of Tiers, a place where gods and mortals coexist, and where the boundaries between myth and reality blur. As Robert navigates this surreal landscape, encountering enigmatic beings, ancient prophecies, and cosmic mysteries, he discovers his role as a pivotal figure in the fabric of Tiers’ existence. Join us as we delve into the rich tapestry of “The Maker of Universes.” From the awe-inspiring landscapes and mythological creatures to the philosophical questions about the nature of creation and existence, Farmer’s novel offers a mind-bending exploration of alternate realities and the power of imagination. Our video immerses you in the fantastical realms of “The Maker of Universes,” delving into the themes of identity, destiny, and the interplay between myth and reality. We explore the intricate world-building, the diverse cultures, and the profound insights into human nature that make this novel a timeless gem in the science fiction and fantasy genre. Whether you’re a fan of epic adventures, mythic storytelling, or tales that challenge your perceptions of reality, “The Maker of Universes” promises an enthralling and thought-provoking reading experience that will transport you to realms beyond imagination. Prepare to unlock the secrets of the multiverse and embark on a journey of cosmic discovery with Philip José Farmer’s visionary masterpiece! 🌌📘 #PhilipJoséFarmer #TheMakerOfUniverses #ScienceFantasy #MultiverseAdventure #MythologicalExploration

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Toothed whales use sound to find their way around, detect objects, and catch fish. They can investigate their environment by making clicking sounds, and then decoding the “echoic return signal” created when the clicking sounds bounce off objects and return to their ears. This “biosonar,” called echolocation, is rare in the animal kingdom.

Now, a new study by researchers at the Woods Hole Oceanographic Institution, New College of Florida, UC Berkeley, and Oxford University, and published in PLOS One, brings us closer to understanding how dolphin brains have evolved to support .

The research team applied new techniques for mapping networks in the excised brains of dead, stranded cetaceans to examine and compare the auditory pathways in echolocating dolphins and a non-echolocating baleen whale called a sei whale. A partnership with the International Fund for Animal Welfare (IFAW) and others is critical to advancing this work.

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IBM has just unveiled its boldest quantum computing roadmap yet: Starling, the first large-scale, fault-tolerant quantum computer—coming in 2029. Capable of running 20,000X more operations than today’s quantum machines, Starling could unlock breakthroughs in chemistry, materials science, and optimization.

According to IBM, this is not just a pie-in-the-sky roadmap: they actually have the ability to make Starling happen.

In this exclusive conversation, I speak with Jerry Chow, IBM Fellow and Director of Quantum Systems, about the engineering breakthroughs that are making this possible… especially a radically more efficient error correction code and new multi-layered qubit architectures.

We cover:
- The shift from millions of physical qubits to manageable logical qubits.
- Why IBM is using quantum low-density parity check (qLDPC) codes.
- How modular quantum systems (like Kookaburra and Cockatoo) will scale the technology.
- Real-world quantum-classical hybrid applications already happening today.
- Why now is the time for developers to start building quantum-native algorithms.

00:00 Introduction to the Future of Computing.
01:04 IBM’s Jerry Chow.
01:49 Quantum Supremacy.
02:47 IBM’s Quantum Roadmap.
04:03 Technological Innovations in Quantum Computing.
05:59 Challenges and Solutions in Quantum Computing.
09:40 Quantum Processor Development.
14:04 Quantum Computing Applications and Future Prospects.
20:41 Personal Journey in Quantum Computing.
24:03 Conclusion and Final Thoughts.

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