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The Conscious Turing Machine (CTM), a formally defined Theoretical model of Consciousness

Manuel Blum (Carnegie Mellon University)
https://simons.berkeley.edu/talks/man
The Role of TCS in Modern Machine Learning.

We define the Conscious Turing Machine (CTM), a formal global workspace model of consciousness specified as a 7-tuple. Its 10 million processors self-define a multimodal language, Brainish, together with a dictionary of chunks. Each chunk is a 5-tuple that contains and defines a 2-tuple Brainish word.

Our principal contribution is not theorems—though there is one—but theoretical insights into several central puzzles of consciousness. From this formal definition follow a proposed solution to the binding problem, an explanation of how the suffering of pain is generated, and testable predictions derived from the CTM.

Team finds brain circuit that helps you switch gears

A new study shows how the brain abandons outdated strategies and adapts to new rules.

Most people have experienced the feeling: switching from one task to another, only to find the brain momentarily stuck in the old mode of thinking. Sometimes, even after realizing a strategy no longer works, the mind keeps returning to it anyway.

Neuroscientists call the ability to adapt and shift strategies “cognitive flexibility”—a core feature of higher cognition that allows the brain to abandon outdated rules and respond to changing conditions. Impairments in cognitive flexibility are associated with disorders including Attention-Deficit/Hyperactivity Disorder (ADHD), depression, obsessive-compulsive disorder (OCD), schizophrenia, and Alzheimer’s disease.

Peter Joseph: We Are All Subjected To The Same Natural Law System

13 years ago, I sat down with Peter Joseph, musician, filmmaker, and founder of the Zeitgeist Movement.

His argument was simple, and uncomfortable: the system we live under (debt-based money, work-for-survival economics, infinite growth on a finite planet) isn’t broken. It’s working exactly as designed. And it’s running out of runway.

In 2013, this sounded radical. In 2026, it sounds like a weather report.

We covered a lot of ground in 75 minutes: the Resource-Based Economy, the role of Artificial Intelligence in managing scarcity, the schism between Zeitgeist and the Venus Project, sustainability, central planning, and the technological singularity itself.

You don’t have to agree with Peter to take the conversation seriously. I don’t agree with all of it. But the questions he was asking back then are the questions we’re being forced to ask now, except we’re asking them in an era when AI systems can actually do things he could only theorize about.

The technology has caught up with the critique. The philosophy hasn’t caught up with the technology.

Lab-designed molecule offers hope for celiac disease sufferers

A research project led by the Institute for Research in Nutrition and Food Safety (INSA) and the Faculty of Pharmacy and Food Sciences at the University of Barcelona, together with the Molecular Biology Institute of Barcelona (IBMB) of the CSIC (which stands for Consejo Superior de Investigaciones Científicas), has successfully designed and tested a gluten-degrading molecule that is a promising ally in the management of celiac disease, an autoimmune disease whose symptoms are triggered by the consumption of gluten and other prolamins found in cereals.

At present, there is a complete lack of treatment options beyond a diet free from gluten, which is difficult to maintain in Western societies where diets rely heavily on wheat products.

The major breakthrough is that the molecule is effective at very low concentrations and at a pH of 2—the pH of the stomach—a condition that none of the molecules currently available or under development had previously achieved with efficiency. Although some of them are marketed as nutritional supplements, they are not an effective alternative to gluten-free diets.

Scientists Built A Disturbingly Accurate AI Brain Simulation

Insights from the Algonauts 2025 Winners.
https://arxiv.org/html/2508.10784v1

A foundation model of vision, audition, and language for in-silico neuroscience.
https://ai.meta.com/research/publicat

How to breathe life back into brain theory.
https://www.nature.com/articles/d4158

A foundation model to predict and capture human cognition.
https://www.nature.com/articles/s4158

#ai #tech #explained #brain #artificialintelligence

Paul Vitányi

Consider teaching a computer how to read by giving it billions of books. You don’t teach it grammar rules or logic; you simply ask it to play a game: “Look at these words, and guess what word comes next.” To win this game at a world-class level, the computer can’t just memorize phrases. It has to start figuring out how the world works. If it’s reading a mystery novel, it needs to deduce who the killer is to guess the final sentence. If it’s reading a math textbook, it has to understand addition to predict the answer to a problem. This is the core idea explored in a recent scientific paper titled “Algorithmic Compression via Pretrained Neural Networks.”*The researchers look under the hood of today’s Large Language Models (LLMs)—like the AI assistants we use every day—to explain a fascinating mystery: Why does a machine trained merely to predict the next word end up looking like it can think, reason, and solve complex problems? Think about how a ZIP file works on your computer. If you have a massive text file filled with the word “apple” repeated a million times, a compression program won’t save all million words. It will compress it into a short rule: “Repeat ‘apple’ 1,000,000 times.” It turns a massive mountain of data into a tiny, elegant recipe. (learning how to learn). Because the AI is fed a massive, diverse diet of information, it can’t just memorize everything. Instead, it is forced to find the underlying “recipes” or rules behind the data it sees. When you type a prompt into an AI, it doesn’t just look up an answer in a database. It looks at your text, infers the “generative algorithm” (the underlying pattern or logic of what you are asking), and uses that pattern to compress the problem and generate the correct response. In essence, it deduces the hidden rules of the game on the fly. * Discover Complex Logic: When given a sequence of chess moves, the AI doesn’t just guess random moves; it actually reconstructs the abstract rules and evaluations of a chessboard in its digital “mind.” While this framework helps explain why AI is getting so smart, it also opens up big new questions. We know these models are compressing data and finding rules, but we still don’t fully understand the absolute limits of this approach. How close can a practical AI get to that theoretical “perfect” intelligence? What happens when the AI runs out of human data to learn from?


Vitányi was appointed professor of computer science at the University of Amsterdam, and researcher at the National Research Institute for Mathematics and Computer Science in the Netherlands (CWI, initially Mathematical Centre [MC]) where he is currently a CWI Fellow. He was guest professor at the University of Copenhagen in 1978; research associate at the Massachusetts Institute of Technology in 1985/1986; Gaikoku-Jin Kenkyuin (councilor professor) at INCOCSAT at the Tokyo Institute of Technology in 1998; visiting professor at Boston University in 2004, at Monash University in 1996 and at the National ICT of Australia NICTA at University of New South Wales in 2004/2005; visiting professor at and adjunct professor of computer science at the University of Waterloo from 2005.

AI model predicts B cell response to advance personalized cancer vaccines

KAIST announced on the 2nd that a team led by Professor Jeong Kyun Choi of the Department of Bio and Brain Engineering, in a joint study with the company ‘Neogene Logic,’ has developed a new AI model to predict neoantigens—a key element in developing personalized cancer vaccines—and has identified the importance of B cells in cancer immunotherapy. The research findings were published in the international journal *Science Advances* on December 3.

Neoantigens are protein fragments derived from cancer cell mutations that serve as unique markers distinguishing only cancer cells. Moderna and BioNTech developed their COVID-19 vaccines using the messenger ribonucleic acid (mRNA) platform secured during their research on neoantigen-based cancer vaccines. Currently, global pharmaceutical companies are actively conducting clinical trials for cancer vaccines.

The problem is that most existing cancer vaccine technologies focus solely on T-cell-centered immune responses. B cells, along with T cells, play a key role in the immune system, and recent studies have increasingly demonstrated their importance in anti-cancer immune activity.

AI-Based Cancer Models in Oncology: From Diagnosis to ADC Drug Prediction

Introduction Artificial intelligence (AI) has been influencing the way oncology has been practiced. Major issues constituting a bottleneck are the lack of data for training purposes, confidentiality preventing development, or the absence of transparency in clarifying how models operate to generate decisions. Novel Models With explainable AI, trust and utilization barriers among clinicians, researchers, and patients can be removed. With the implementation of federated learning, multiple institutions could contribute to crucial dataset’s learning information. Precise diagnosis and prescription of the right drug are essential in preventing unnecessary life losses, and economic burden to the underling system.

Just 1.2 billion years after the Big Bang, galaxies were already shaped by where they lived

A large protocluster of galaxies that existed 12.6 billion years ago, first discovered with the Subaru Telescope, has been examined in detail using the James Webb Space Telescope (JWST). The study found that galaxies in crowded regions are more extended than similar galaxies in less dense environments. The results, published in The Astrophysical Journal Letters, show that even when the universe was only 1.2 billion years old, environment was already influencing how galaxies grow.

In today’s universe, galaxies are not spread evenly through space. They have gathered into groups, and those groups form enormous galaxy clusters containing hundreds or even thousands of galaxies. But these giant structures did not exist at the beginning of the universe.

In the early universe, slightly denser regions of matter gradually grew under gravity and eventually developed into galaxy clusters. These “seeds” of galaxy clusters are known as protoclusters.

After 100 years, scientists finally uncover hidden rule behind cosmic rays

A mysterious new cosmic pattern discovered by the DAMPE space telescope may finally crack the century-old mystery of cosmic rays. Scientists studying mysterious ultra-powerful cosmic rays have uncovered a surprising hidden pattern that could finally help explain where these particles come from. Using the DAMPE space telescope, researchers found that cosmic ray particles—from tiny protons to heavy iron nuclei—all begin fading away more sharply at the exact same point, hinting at a universal rule governing their behavior across the galaxy.

For more than 100 years, scientists have been trying to understand cosmic rays, incredibly powerful particles that travel across the universe at extreme energies. Despite decades of research, many questions about where they come from and how they are accelerated remain unanswered. Now, researchers working with the DAMPE (Dark Matter Particle Explorer) space telescope have uncovered an important new clue. Their findings, published in Nature, reveal a common feature shared by these mysterious particles and could help scientists better understand their origins.

Cosmic rays are the highest energy particles ever observed in nature. They carry far more energy than particles produced by even the most advanced accelerators on Earth. Scientists believe they are created by some of the universe’s most violent events, including supernova explosions, jets from black holes, and pulsars.

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