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Unreal Engine 6 — No C++ — No Blueprints?!?! Wow!😲

We just got some major news about Unreal Engine 6 from Unreal Fest Tokyo 2026 about the future of C++ and Blueprints in UE6… They have no future, at least as far as gameplay programming goes. It was previously announced the Blueprints will be deprecated in Unreal Engine 6 — now they are being removed completely. When it comes to C++, it’s a bit more complicated, with the entire C++ Gameplay Framework being removed. Going forward gameplay programming is meant to be done with Verse + AI prompting only. We discuss exactly what that means in this video.

GFS Link — https://gamefromscratch.com/the-futur…

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Decomp vs Recomp vs Emulation: The AI Gaming Revolution Explained

Recently, AI-driven game recompilations have been taking over the PC gaming space, but what makes them different from traditional emulators? I break down the difference between decompilations, recompilations, and emulators. Discover the six primary reasons why running a game natively on your PC via a recomp can be vastly superior to mimicking a console through emulation, from performance gains on lower-end hardware to future-proof game preservation.

Chapters:
0:00 The AI Recompilation Trend.
0:49 Why PC Gamers Want Console Ports.
2:27 D-Comps, Recomps, and the Bread Analogy.
4:14 Why a Recomp is NOT an Emulator.
5:08 6 Reasons Recompiling is Better than Emulating.
7:40 The Bottom Line.

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Porting OutRun with Claude AI: When AI Fails & Human Touch is Needed

In the last video, we decompiled and recompiled Poker Smash from the Xbox Live Arcade. Today, we’re doing the same thing with OutRun, but this one came with a ton of challenges!

Watch as I spend days trying to fix a persistent audio crackling bug that Claude AI just couldn’t figure out on its own.

AI isn’t infallible, and I wanted to show you what a difficult port looks like when the human touch is absolutely necessary to cross the finish line. We also answer your comments and questions from the last recomp video, including whether Claude is still letting me do this, the total cost of running these sessions, and why I didn’t just use a fleet of AI agents to automate the work.

NOTE: The terms decomp, recomp and static recompilation are often used interchangeably — and I’m as guilty as anyone for it. Decompilation is where you return human readable source code from the process. The Deluxe Galaga 2026 project I’m involved with is exactly that. We have source code from a long dead game now. RECOMP or \.

Plant-derived compound helps restore cancer cells’ sensitivity to treatment

A natural plant compound may help overcome a built-in defense that allows many cancers to resist a class of drugs designed to restore normal gene activity, according to a study by researchers at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center.

The researchers found that triptolide, a natural compound from Tripterygium wilfordii, commonly known as thunder god vine, blocks an enzyme called DCTPP1 that cancer cells can use to break down DNA methyltransferase inhibitors, or DNMT inhibitors, before the drugs can fully work. When researchers combined triptolide or related compounds with the DNMT inhibitor decitabine, it dramatically boosted the drug’s ability to reactivate tumor suppressor genes and kill cancer cells in laboratory models.

The findings, published Aug. 26 in Nature Communications, suggest a potential strategy for overcoming resistance to DNMT inhibitors and expanding their use to more types of cancer.

Advanced imaging tool improves detection of residual multiple myeloma disease

A targeted immunoPET scan detected active multiple myeloma that standard PET/CT scans and blood tests missed, a finding that could help doctors more accurately map disease, guide treatment decisions and confirm whether cancer remains after therapy. The phase 2 clinical trial was led by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.

Multiple myeloma is a disease that can remain hidden in plain sight. This blood cancer grows in the bone marrow but spreads to many places in the body. Doctors can use advanced imaging and newer blood tests to look for disease, but these tests do not always tell the full story, which can affect everything from diagnosis to treatment decisions.

Now, Sylvester researchers have shown that a targeted imaging approach can detect active myeloma that standard tests miss. The study, published in Radiology, used immunoPET, a new type of labeled antibodies that find and attach directly to myeloma cells.

Two flavors of superconductivity: Material has right ingredients for a twist

Quantum researchers are searching for a topological superconductor – a material that, if discovered, would allow major advances in quantum computing by combining two distinct “flavors” of superconductivity.

This potent material remains elusive, but Cornell researchers have demonstrated that uranium ditelluride can exhibit both flavors at once, setting it apart as the leading candidate.

“No one has yet convincingly demonstrated a topological superconductor, but now we know that uranium ditelluride at least has the right ingredients to make it happen,” said Brad Ramshaw, associate professor of physics in the College of Arts and Sciences and director of the Laboratory of Atomic and Solid State Physics.

Researchers identify specific gene linked to female protection from autism

In many cases all it takes is one mutated gene to orchestrate changes across a whole network of genes linked to autism, according to new results published today in Nature by researchers at Boston Children’s Hospital. The finding could explain why different mutations in one or several of the hundreds of genes linked to autism can lead to a similar condition. And further building on this discovery, the investigators also found that one gene in particular, ZFX, is central to a well-known effect whereby females are relatively protected from severe autism symptoms even when they carry autism-associated mutations.

Senior study author Christopher Walsh, MD, PhD, chief of the Division of Genetics and Genomics and Investigator of the Howard Hughes Medical Institute, and lead authors Rebecca Andersen, PhD and Maya Talukdar, PhD, along with colleagues studied a number of genes linked to autism in a human cell model. They observed similar genetic patterns in most cases regardless of which gene was disrupted.

“The point is, if you down-regulate one autism gene, you down-regulate a whole bunch of them,” said Andersen. “This ‘transcriptomic convergence,’ as we call it, gives us a way to understand how hundreds of different genes can cause similar phenotypes, a similar condition.”

A programmable DNA origami nanosyringe for directed membrane translocation

An extremely cool DNA origami nanodevice which can be induced to penetrate lipid membranes and transport/inject molecules of interest. It should be noted that the authors used artificial vesicles (not living cells) for their proof-of-concept. That said, I think the device has potential if it can be modified for robustness in biological environments.


A membrane-anchoring nanodevice that integrates reversible, fuel-driven mechanical actuation enables programmable membrane penetration, cargo delivery and spatiotemporal regulation of biochemical reactions in synthetic cells.