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Ovarian cancer is usually diagnosed only after it has reached an advanced stage, with many tumors spread throughout the abdomen. Most patients undergo surgery to remove as many of these tumors as possible, but because some are so small and widespread, it is difficult to eradicate all of them.

Researchers at MIT, working with surgeons and oncologists at Massachusetts General Hospital (MGH), have now developed a way to improve the accuracy of this surgery, called debulking. Using a novel fluorescence imaging system, they were able to find and remove tumors as small as 0.3 millimeters—smaller than a poppy seed—during surgery in mice. Mice that underwent this type of image-guided surgery survived 40 percent longer than those who had tumors removed without the guided system.

“What’s nice about this system is that it allows for real-time information about the size, depth, and distribution of tumors,” says Angela Belcher, the James Mason Crafts Professor of Biological Engineering and Materials Science at MIT, a member of the Koch Institute for Integrative Cancer Research, and the recently appointed head of MIT’s Department of Biological Engineering.

Continue reading “Imaging system helps surgeons remove tiny ovarian tumors” »

Holograms are a staple in science fiction, but creating ones detailed enough to have serious applications in the real world has proved difficult. While scientists have been slowly pushing the field of holographic projection forward, they haven’t been able to overcome a problem called cross-talk. However, in a recent paper published in Nature, they have been able to manipulate the shape of light to overcome this, thus allowing them to produce 3D holograms that are orders of magnitude clearer, larger, and more detailed.

What Are Holograms?

Simple holograms are 2D surfaces that produce the illusion of a 3D object when light is shined through it.

Continue reading “Solving a Math Problem Just Brought Holograms Closer to Reality” »

Elon Musk has tweeted that Tesla will make a quiet electric leaf blower.

In 2017, the California Air Resources Board, said that by 2020, the biggest single ozone polluter in California is going to be all this gardening equipment.

California has 16 million gas-powered garden machines from leaf blowers to mowers.

Continue reading “Telsa Will Make an Electric Leafblower As Garden Equipment is a Big Pollution Source” »

Bioengineers at Boston Children’s Hospital report the first demonstration of a robot able to navigate autonomously inside the body. In an animal model of cardiac valve repair, the team programmed a robotic catheter to find its way along the walls of a beating, blood-filled heart to a leaky valve—without a surgeon’s guidance. They report their work today in Science Robotics.

Surgeons have used robots operated by joysticks for more than a decade, and teams have shown that tiny robots can be steered through the body by external forces such as magnetism. However, senior investigator Pierre Dupont, Ph.D., chief of Pediatric Cardiac Bioengineering at Boston Children’s, says that to his knowledge, this is the first report of the equivalent of a self-driving car navigating to a desired destination inside the body.

Dupont envisions autonomous robots assisting surgeons in complex operations, reducing fatigue and freeing surgeons to focus on the most difficult maneuvers, improving outcomes.

Continue reading “A first in medical robotics: Autonomous navigation inside the body” »

A special focus on rogue proteins may hold future promise in stopping the progression of nerve cell destruction in people who have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia.

ALS, a rare but devastating disorder that’s also known as Lou Gehrig’s disease, attacks the body’s nerve cells, resulting in progressive muscle weakness as the neurons degenerate over time. There is no cure. People with ALS eventually lose their strength and the ability to move their arms, legs and body.

About a third of those with ALS also develop frontotemporal dementia (FTD), a destruction of neurons in the brain that causes profound personality changes and disability. The two diseases are similar in both pathology and genetics. FTD tends to affect people earlier than Alzheimer’s disease, the most common type of dementia.

Continue reading “A new clue in the mystery of ALS, frontotemporal dementia” »

By breaking with conventionality, University of Otago physicists have opened up new research and technology opportunities involving the basic building block of the world—atoms.

In a study, just published in Nature Communications, researchers put one atom inside each of two laser beams before moving them together until they started to interact with each other.

Co-author Associate Professor Mikkel F. Andersen, of the Department of Physics, says this allows the atoms to exchange properties in a way which could be “very useful” for future quantum technologies.

Continue reading “Atom interaction discovery valuable for future quantum technologies” »

I suspect that if you asked an engineer at Intel about quantum computing, they probably wouldn’t want to know about it unless the chips could be fabricated using standard fabrication technology. Using standard processes means using electrons as the basis for quantum computing.

Electrons are lovely in many respects, but they are rather extroverted. It doesn’t matter what you do, they will run off and play with the neighbors. The constantly interacting electron does not look after its quantum state, so quantum information is rapidly lost, making processing really difficult. This makes the achievement of a quantum non-demolition measurement in an electron system rather remarkable.

Using human cancer cells, tumor and blood samples from cancer patients, researchers at Johns Hopkins Medicine have uncovered the role of a neurotransmitter in the spread of aggressive cancers. Neurotransmitters are chemical “messengers” that transmit impulses from neurons to other target cells.

The work, described in the April 9 issue of the journal Cell Reports, found that this neurotransmitter, called N-acetyl-aspartyl-glutamate (NAAG) NAAG is more abundant in cancers with a tendency to grow and spread rapidly—or so-called higher grade cancers—than in lower grade tumors, making it a potential marker for tumor progression or regression during cancer therapy, the researchers say. The experiments also demonstrated that NAAG is a source of glutamate, a chemical that cancer cells use as building blocks to survive, in tumors that express an enzyme called glutamate carboxypeptidase II (GCPII). The group also discovered that stopping the GCPII from being active by using a drug called 2-PMPA to treat human ovarian tumors implanted in ovaries of mice, reduced tumor weights and glutamate concentrations.

The city’s new green building legislation will result in the equivalent of taking more than one million cars off the road by 2030.