Lifeboat Foundation

The folks at Kurzgesagt have created another great video about aging and thanks to them for giving us the opportunity to work with them in creating this video. If you would like to support our work check out (https://www.lifespan.io/campaigns/join-us-become-a-lifespan-hero/).

The video today discusses the near future technologies that are changing how we treat aging and could potentially bring it under medical control soon. It is important to discuss this topic now and its great to see popular channels like Kurzgesagt are keen to get involved in that dialogue.

The CRISPR-Cas9 system has revolutionised gene-editing, but cutting DNA isn’t all it can do. From turning gene expression on and off to fluorescently tagging particular sequences, this animation explores some of the exciting possibilities of CRISPR.

Download a poster on ‘The expanding CRISPR toolbox’ here: https://www.nature.com/posters/crisprtoolbox

Continue reading “Gene editing and beyond” »

China’s heaviest cargo unmanned aerial vehicle (UAV) AT200 prepares for its maiden flight in Neifu Airport in Pucheng, northwest China’s Shaanxi Province, Oct. 26, 2017. China’s heaviest cargo unmanned aerial vehicle (UAV) completed its maiden flight in northwest China’s Shaanxi Province Thursday. With a maximum take-off weight of around 3.4 tonnes and a payload of 1.5 tonnes, the AT200 could be one of the world’s most powerful civilian UAVs. (Xinhua)

BEIJING, Oct. 27 (Xinhua) — China’s heaviest cargo unmanned aerial vehicle (UAV) completed its maiden flight in northwest China’s Shaanxi Province Thursday.

The AT200 drone, jointly developed by several research institutes and companies, made a successful 26-minute maiden flight, according the Institute of Engineering Thermophysics.

In many ways, stem cells are the divas of the biological world. On the one hand, these natural shapeshifters can transform themselves into virtually any type of cell in the body. In that regard, they hold the promise of being able to cure ills ranging from spinal cord injuries to cancers.

On the other hand, said associate professor of materials science and engineering Sarah Heilshorn, stem cells, like divas, are also mercurial and difficult to work with.

“We just don’t know how to efficiently and effectively grow massive numbers of stem cells and keep them in their regenerative state,” Heilshorn said. “This has prevented us from making more progress in creating therapies.”

A new drug being trialled for treating breast cancer and diabetes has been shown to ‘melt away’ the fat inside arteries that can cause heart attacks and strokes.

Researchers from the University of Aberdeen, using pre-clinical mouse models, showed that just a single dose of the drug (Trodusquemine) completely reversed the effects of a disease that causes a host of heart problems.

Atherosclerosis is the build-up of fatty material inside the arteries.

The big roll out is set for 2021–2022.

A decade ago, there wasn’t much talk about self-driving cars or autonomous-cars, but Toyota and Lexus were setting the stage with their self-parking cars. They aired television commercials showing how cars magically parallel-parked themselves. That was before any mention of the first iPhone or Android. At the time, it seemed amazing, but that was nothing compared to what’s coming next.

The self-parking revolution that spread throughout the automotive industry over the last decade is now expanding. There is more technology in cars today than ever before: navigation systems, automatic updates wirelessly downloaded to the dashboard, in-cabin WiFi and much more.

Click here to subscribe to The Economist on YouTube: http://econ.trib.al/rWl91R7

By 2050, two thirds of the world’s population will live in cities. Urbanisation is happening faster than at any time in human history.

Continue reading “Transforming cities with technology” »

Understanding the factors that control aging has been one of humanity’s endless pursuits, from the mystical fountain of youth to practical healthful regimens to prolong life expectancy.

A team of scientists at the University of California San Diego has helped decipher the dynamics that control how our cells age, and with it implications for extending human longevity. As described in a study published in the Proceedings of the National Academy of Sciences, a group led by biologist Nan Hao employed a combination of technologies in engineering, computer science and biology to analyze molecular processes that influence aging.

As cells age, damage in their DNA accumulates over time, leading to decay in normal functioning and eventually resulting in death. A natural biochemical process known as “chromatin silencing” helps protect DNA from damage. The silencing process converts specific regions of DNA from a loose, open state into a closed one, thus shielding DNA regions. Among the molecules that promote silencing is a family of proteins—broadly conserved from bacteria to humans—known as sirtuins. In recent years, chemical activators of sirtuins have received much attention and are being marketed as nutraceuticals to aid chromatin silencing in the hopes of slowing the aging process.

Continue reading “Scientists decipher mechanisms underlying the biology of aging” »

A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes — a specific virus and two specific types of bacteria — are major causes of Alzheimer’s Disease. Their paper, which has been published online in the highly regarded peer-reviewed journal, Journal of Alzheimer’s Disease, stresses the urgent need for further research — and more importantly, for clinical trials of anti-microbial and related agents to treat the disease.

This major call for action is based on substantial published evidence into Alzheimer’s. The team’s landmark editorial summarises the abundant data implicating these microbes, but until now this work has been largely ignored or dismissed as controversial — despite the absence of evidence to the contrary. Therefore, proposals for the funding of clinical trials have been refused, despite the fact that over 400 unsuccessful clinical trials for Alzheimer’s based on other concepts were carried out over a recent 10-year period.

Opposition to the microbial concepts resembles the fierce resistance to studies some years ago which showed that viruses cause certain types of cancer, and that a bacterium causes stomach ulcers. Those concepts were ultimately proved valid, leading to successful clinical trials and the subsequent development of appropriate treatments.

Continue reading “Landmark editorial identifies microbes as major cause of Alzheimer’s Disease” »