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The Brain’s Best Defense Against Aging Could Be Your New Favorite Hobby

Getting older means losing things. Some are fine, like any f**ks you have left to give or your tolerance for cheap tequila. Others, like the ability to follow a conversation in a loud room, hit harder.

But scientists now think there’s a way to fight back. And it might start at a piano bench.

Researchers publishing in PLOS Biology found that older adults who have played music for decades have brains that function more like those of someone half their age, at least when it comes to understanding speech in loud environments. In brain scans, they showed cleaner, more focused activity while listening to spoken syllables buried in background noise. Their brains weren’t scrambling. They already knew what to do.

Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease

Vascular aging and genetic risk jointly shape coronary artery disease susceptibility across races and sexes.


BackgroundEstimated pulse wave velocity (ePWV), a noninvasive marker of arterial stiffness, reflects vascular aging and has been associated with increased coronary artery disease (CAD) risk. However, the interplay between ePWV and genetic factors, including polygenic risk score (PRS) and apolipoprotein E genotypes, in determining CAD susceptibility remains unclear.

Monogenic Mimics of Neuroinflammatory Phenotypes in Children and Young AdultsAn Evolving Landscape

This review examines some of the monogenic disorders that can masquerade as neuroinflammatory phenotypes.


A recent explosion in genomic testing has led to the identification of several genetic disorders that mimic CNS-specific autoimmune disorders. Such monogenic disorders, although rare, represent a diagnostic challenge because of their diverse phenotypes and overlapping features. Early recognition of these disorders is crucial not only to prevent overtreatment with immunotherapy but also to ensure that targeted treatments are available for many of these disorders. This review explores some of the monogenic disorders that can masquerade as neuroinflammatory phenotypes. These clinical vignettes are stratified according to neuroanatomical localization along the neuroaxis: supratentorial white matter, gray matter, brainstem, and spinal cord involvement.

The Man Who Reimagined Math: David Deutsch And The Universal Quantum Computer

David Deutsch didn’t just contribute to the field of quantum computing—he redefined what computation *is*, bridging the gap between physics and information in a way no one had before. By theorizing the universal quantum computer, Deutsch opened the door to possibilities previously confined to science fiction, forever altering our understanding of reality and the limits of what machines can achieve.

Cerebral sulci and fissures

Cerebral sulci and fissures are grooves between the adjacent gyri on the surface of the cerebral hemispheres. By allowing the cortex to invaginate to form sulci and gyri the surface area of the cortex is The result is that the surface area of the human cortex is 2,200 cm2, only a third of which can be seen on the surface 4.

Gyri and sulci vary slightly in their dimensions and morphology between individuals or even between hemispheres. Some may not be present in a number of individuals and others deep enough to produce elevations on the surface of the ventricles (e.g. collateral sulcus, calcarine sulcus/calcar avis) 4. However, these variations are generally of no functional significance. In contrast, disorders of cortical formation can be associated with numerous and significant neurological symptoms and deficits.

Radiopedia:.

Room temperature electron behavior defies expectations, hinting at ultra-efficient electronics

Scientists have discovered a way to efficiently transfer electrical current through specific materials at room temperature, a finding that could revolutionize superconductivity and reshape energy preservation and generation.

The paper is published in the journal Physical Review Letters.

The much-sought-after breakthrough hinges on applying high pressure to certain materials, forcing their electrons closer together and unlocking extraordinary electronic behaviors.

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