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A protein ‘tape recorder’ enables scientists to measure and decode cellular processes at scale and over time

Unraveling the mysteries of how biological organisms function begins with understanding the molecular interactions within and across large cell populations. A revolutionary new tool, developed at the University of Michigan, acts as a sort of tape recorder produced and maintained by the cell itself, enabling scientists to rewind back in time and view interactions on a large scale and over long periods of time.

Developed in the lab of Changyang Linghu, Ph.D., Assistant Professor of Cell and Developmental Biology and Biomedical Engineering and Principal Investigator in Michigan Neuroscience Institute, the so-called CytoTape is a flexible, thread-like intracellular protein fiber, designed with the help of AI to act as a tape recorder for large-scale measurement of cellular activities.

The research appears in the journal Nature.

Mapping cell development with mathematics-informed machine learning

The development of humans and other animals unfolds gradually over time, with cells taking on specific roles and functions via a process called cell fate determination. The fate of individual cells, or in other words, what type of cells they will become, is influenced both by predictable biological signals and random physiological fluctuations.

Over the past decades, medical researchers and neuroscientists have been able to study these processes in greater depth, using a technique known as single-cell RNA sequencing (scRNA-seq). This is an experimental tool that can be used to measure the gene activity of individual cells.

To better understand how cells develop over time, researchers also rely on mathematical models. One of these models, dubbed the drift-diffusion equation, describes the evolution of systems as the combination of predictable changes (i.e., drift) and randomness (i.e., diffusion).

High-resolution map shows dark matter’s gravity pulled normal matter into galaxies

Scientists have created the highest resolution map of the dark matter that threads through the universe—showing its influence on the formation of stars, galaxies and planets.

The research, including astronomers from Durham University, UK, tells us more about how this invisible substance helped pull ordinary matter into galaxies like the Milky Way and planets like Earth.

The findings, using new data from NASA’s James Webb Space Telescope (Webb), are published in the journal Nature Astronomy.

Mighty microscopic fibers are the key to cell division and life itself

Every second, millions of cells in your body divide in two. In the space of an hour, they duplicate their DNA and grow a web of protein fibers around it called a spindle. The spindle extends its many fibers from the chromosomes in the center to the edges of the cell. Then, with extraordinary force, it pulls the chromosomes apart.

How the spindle accomplishes this without destroying itself has long been a mystery.

Now, scientists at UC San Francisco have discovered that the spindle can repair itself as it’s pulling on the DNA, replacing weak links while it’s working. This constant reinforcement ensures that the DNA is divided exactly in two. Putting just one extra chromosome in a cell could lead to cancer or birth defects.

The shape of things to come: How spheroid geometry guides multicellular orbiting and invasion

As organisms develop from embryos, groups of cells migrate and reshape themselves to form all manner of complex tissues. There are no anatomical molds shaped like lungs, livers or other tissues for cells to grow into. Rather, these structures form through the coordinated activity of different types of cells as they move and multiply.

No one is sure exactly how cells manage this collective construction of complex tissue, but a study by Brown University engineers could offer some new insights.

The study, published in Nature Physics, looked at how human epithelial cells behave as spherical aggregates confined inside a collagen matrix. The research revealed surprising ways in which cell clusters first rotate collectively within the confined space, then eventually reconfigure their surroundings to allow individual cells to venture out of the sphere.

Microgravity rewires microbial metabolism, limiting space-based manufacturing efficiency

Scientists at the U.S. Naval Research Laboratory (NRL) have completed a spaceflight biology investigation aboard the International Space Station (ISS) that reveals how microgravity fundamentally alters microbial metabolism, limiting the efficiency of biological manufacturing processes critical to future long-duration space missions. The findings were recently published in the journal npj Microgravity.

The Melanized Microbes for Multiple Uses in Space Project (MELSP), launched to the space station in November 2023, examined how microgravity affects the ability of engineered microbes to produce melanin, a multifunctional biopolymer known for its radiation-shielding, antioxidant, and thermal stable properties.

Results from the completed mission show that while microbes remain capable of producing melanin in space, microgravity significantly interferes with substrate transport, cellular stress responses, and metabolic balance, ultimately reducing production efficiency.

Swimming in a shared medium makes particles synchronize without touching

Several years ago, scientists discovered that a single microscopic particle could rock back and forth on its own under a steady electric field. The result was curious, but lonely. Now, Northwestern University engineers have discovered what happens when many of those particles come together. The answer looks less like ordinary physics and more like mystifying, flawlessly timed choreography.

The study appears in the journal Nature Communications.

In the work, the team found that groups of tiny particles suspended in liquid oscillate together, keeping time as though they somehow sense one another’s motion. Nearby particles fall into sync, forming clusters that appear to sway in unison—rocking back and forth with striking coordination.

Collaboration of elementary particles: How teamwork among photon pairs overcomes quantum errors

Some things are easier to achieve if you’re not alone. As researchers from the University of Rostock, Germany have shown, this very human insight also applies to the most fundamental building blocks of nature.

At its very core, quantum mechanics postulates that everything is made out of elementary particles, which cannot be split up into even smaller units. This made Ph.D. candidate Vera Neef, first author of the recent publication “Pairing particles into holonomies,” wonder: “What can two particles only accomplish if they work as a team? Can they jointly achieve something, that is impossible for one particle alone?”

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