BRCA1-mediated DNA recombination repair and tumor suppression.
BRCA1 is dispensable for end resection at replication-coupled double-strand breaks (DSBs) but stimulates processing of replication-independent DSBs.
BRCA1 promotes RAD51 assembly downstream of end resection.
Canonical BRCA1/RAD51-dependent homologous recombination is essential for tumor suppression.
Loss of 53BP1 enables alternative BRCA1-independent RAD51 assembly.
Alternative BRCA1-independent RAD51 assembly supports tissue development but is not sufficient for tumor suppression. sciencenewshighlights ScienceMission https://sciencemission.com/BRCA1-mediated-DNA-recombination-repair









