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Nexus between genomic instability and metabolism in cancer.

Genomic damage detection and repair in the cells is enabled by the DNA-damage response (DDR).

Although DDR inhibition has been used to treat various cancers, drug resistance has been observed in the long run owing to the ability of tumor cells to undergo energetic metabolic reprogramming.

In addition, tumor cells’ ability to sense oxidative stress influenced by metabolic intermediates, leading to impaired redox metabolism, thus creating redox vulnerabilities.

The researchers in this review summarize recent advances in understanding the crosstalk between DDR and metabolism and discuss combination therapies that target DDR, metabolism, and redox vulnerabilities in cancer.

They also outline challenges in targeting metabolism and strategies to improve the shortcomings. https://sciencemission.com/Unraveling-the-nexus

Continue reading “Intestinal immune cell prevents food allergies” | >

Previous studies reported that the association between statins use and influenza infection was contradictory. A systematic review and meta-analysis of longitudinal studies were performed to determine the association between statins use and influenza susceptibility. The literature search was conducted in PubMed, Embase, and Web of Science, from each database’s inception to 21 May 2023. The fixed effect model and random effects model were used for data synthesis. In our study, a total of 1,472,239 statins users and 1,486,881 statins non-users from five articles were included. The pooled risk ratio (RR) of all included participants was 1.05 (95% CI: 1.03–1.07), and there were still significant differences after adjusting for vaccination status. Of note, RR values in statins users were 1.06 (95% CI: 1.03–1.08) in people aged ≥60 years old and 1.05 (95% CI: 1.03–1.07) in participant groups with a higher proportion of females. Administration of statins might be associated with an increased risk of influenza infection, especially among females and elderly people. For those people using statins, we should pay more attention to surveillance of their health conditions and take measures to prevent influenza infection.

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The use of virtual reality haptic simulators can enhance skill acquisition and reduce stress among dental students during preclinical endodontic training, according to a new study published in the International Endodontic Journal. The study was based on collaboration between the University of Eastern Finland, the University of Health Sciences and the University of Ondokuz Mayıs in Turkey as well as Grande Rio University in Brazil.

The study aimed to evaluate the influence of virtual reality (VR) haptic simulators on skill acquisition and stress reduction in endodontic preclinical education of dental students.

During preclinical training, dental students develop manual dexterity, psychomotor skills and confidence essential in clinical practice. VR and haptic technology are increasingly used alongside conventional methods, enabling more repetition and standardised feedback, among other things.

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Neuropathic pain caused by nerve damage results in neuronal pathway changes and immune cell engagement. In this Review, Malcangio and Sideris-Lampretsas discuss how microglia respond to and modulate neuronal activity and suggest that microglia–neuron pathways offer novel approaches for the attenuation of neuropathic pain.

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TAMPA, Fla. — British in-orbit manufacturing venture Space Forge has appointed technology veteran Atul Kumar to set up a semiconductor business in the United States, aiming to bolster domestic chip production as efforts to reduce reliance on foreign suppliers gather pace.

Kumar, a materials scientist with more than two decades of experience in the sector, is tasked with developing manufacturing operations under Space Forge’s U.S. subsidiary to support the terrestrial and in-space growth of semiconductor substrates, the company announced April 10.

The move comes as the U.S. ramps up efforts to reduce its dependence on chips from abroad, driven by supply chain disruptions, national security concerns and mounting trade tensions — particularly with China.

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COLORADO SPRINGS – Military space leaders continue looking for ways to inject commercial technologies into their architectures. For strategic communications and positioning, navigation and timing, though, true commercial alternatives may not exist.

That was one takeaway from an April 8 press briefing with Space Systems Command (SSC) officials.

“We will continue to leverage more and more commercial wherever possible,” said Charlotte Gerhart, deputy director of SSC’s Military Communications and Positioning, Navigation & Timing Directorate. “That doesn’t mean everything that commercial has fits every single need.”

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COLORADO SPRINGS — The head of the U.S. Space Force sought to clear up confusion about the Trump administration’s ambitious missile defense initiative known as Golden Dome, emphasizing that it represents a complex network of systems rather than a single procurement program.

“It’s not a system. There’s not going to be a ‘Golden Dome delivered,’” Gen. Chance Saltzman, chief of space operations, said April 9 at a news conference during the Space Symposium. “It’s a system of systems that has to work together. And so there won’t be a single contract vehicle. There will be multiple programs that are brought to bear to solve that mission against the threats.”

The Golden Dome initiative, established through a White House executive order, aims to create a comprehensive shield protecting the United States against an array of missile threats, including ballistic, hypersonic and advanced cruise missiles.

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Researchers from the University of Waterloo have proposed a new method to measure the Hubble constant that could help resolve one of modern cosmology’s pressing puzzles: the Hubble tension.

The study published in Physical Review Letters aims to resolve the Hubble tension, a discrepancy between the value of the Hubble constant (H0) from the local (distance ladder) method and the (CMB) method.

Phys.org spoke to the first author of the study, Dr. Alex Krolewski, a postdoctoral researcher at the University of Waterloo.

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