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Prenatal caffeine exposure induces autism-like behaviors in offspring under a high-fat diet via the gut microbiota-IL-17A-brain axis

This recently published research is compelling. “Microbiota-IL-17A-brain axis… induced ASD” both in and out of the womb has been our focus in learning about injury. ‘’ https://www.sciencedirect.com/science/article/pii/S0147651323013015 Interesting to see differences related to sex given much higher ASD rates in males, though that ratio has changed over the years.

You may be able to guess what kinds of things can affect microbiota-IL-17A-brain axis in infants, leading to neutrophil activity and brain inflammation in context of gut dysbiosis, a microbial predisposition to adverse reaction and injury. No research is published on this dynamic. Zero. microbiomevaccinesafetyproject Note: this is also the pathway explaining fever reducing symptoms in autism, a double-edged sword. https://www.facebook.com/share/p/1C3ZjUoV8k/

Prenatal caffeine exposure (PCE) is a significant contributor to intrauterine growth retardation (IUGR) in offspring, which has been linked to an increased susceptibility to autism spectrum disorder (ASD) later in life. Additionally, a high-fat diet (HFD) has been shown to exacerbate ASD-like behaviors, but the underlying mechanisms remain unclear. In this study, we first noted in the rat model of IUGR induced by PCE that male PCE offspring exhibited typical ASD-like behaviors post-birth, in contrast to their female counterparts. The female PCE offspring demonstrated only reduced abilities in free exploration and spatial memory. Importantly, both male and female PCE offspring displayed ASD-like behaviors when exposed to HFD.

Algorithm matches drugs to glioblastoma’s diverse cell types, offering hope for individualized therapies

Researchers have developed a new computational approach that uncovers possible drugs for specific cellular targets for treating glioblastoma, a lethal brain tumor. This approach enabled them to predict more effective treatment combinations to fight the disease on an individualized basis.

This laboratory and computational research effort was led by scientists at Georgetown’s Lombardi Comprehensive Cancer Center.

“The cellular targets we identified could be key to effectively fighting a disease that has seen only one new targeted drug approved in the last two decades,” says Nagi G. Ayad, Ph.D., senior author, associate director for translational research, and professor of oncology at Georgetown Lombardi.

Quantum mechanics works, but it doesn’t describe reality

Physicists like Sean Carroll propose not only that quantum mechanics is not only a valuable way of interpreting the world, but actually describes reality, and that the wave function – the centre equation of quantum mechanics – describes a real object.

But, in this article, philosophers Raoni Arroyo and Jonas R. Becker Arenhart argue that the case for wave function realism is deeply confused. While it is a useful component within quantum theory, this alone doesn’t justify treating it as literally real.

Tap the link to read more.

Physicists like Sean Carroll argue not only that quantum mechanics is not only a valuable way of interpreting the world, but actually describes reality, and that the central equation of quantum mechanics – the wave function – describes a real object in the world. But philosophers Raoni Arroyo and Jonas R. Becker Arenhart warn that the arguments for wave-function realism are deeply confused. At best, they show only that the wave function is a useful element inside the theoretical framework of quantum mechanics. But this goes no way whatsoever to showing that this framework should be interpreted as true or that its elements are real. The wavefunction realists are confusing two different levels of debate and lack any justification for their realism. The real question is: does a theory need to be true to be useful?

1. Wavefunction realism

Quantum mechanics is probably our most successful scientific theory. So, if one wants to know what the world is made of, or how the world looks at the fundamental level, one is well-advised to search for the answers in this theory. What does it say about these problems? Well, that is a difficult question, with no single answer. Many interpretative options arise, and one quickly ends up in a dispute about the pros and cons of the different views. Wavefunction realists attempt to overcome those difficulties by looking directly at the formalism of the theory: the theory is a description of the behavior of a mathematical entity, the wavefunction, so why not think that quantum mechanics is, fundamentally, about wavefunctions? The view that emerges is, as Alyssa Ney puts it, that.

Continue reading “Quantum mechanics works, but it doesn’t describe reality” | >

Two views of a rogue planet

Simultaneous ground-and space-based observations of a newly discovered free-floating planet have enabled direct measurement of its mass and distance from Earth, according to a new Science study.

The findings offer insights into the diverse and dynamic pathways by which planets can be cast adrift into interstellar space.

Learn more in a new Science Perspective.

A collaboration between ground and space observations unveils a rogue planet.

Gavin A. L. Coleman Authors Info & Affiliations

Science

Continue reading “Two views of a rogue planet” | >

The AI & Quantum Revolution Reshaping Innovation

The AI & quantum revolution: redefining research & development, manufacturing & technological exploration

By Chuck Brooks

By Chuck Brooks, president of Brooks Consulting International

We are at a crucial juncture in the annals of technical history. Throughout decades of writing, lecturing, teaching and consulting on emerging technologies, I have observed cycles of invention transform companies, governments and society. The current frontier—a synthesis of artificial intelligence and quantum technologies—is propelling that shift more rapidly and deeply than ever before. These technologies are transforming research methodologies and changing the architecture of production and discovery, presenting remarkable potential alongside significant constraints.

Research & development reconceived: accelerated, intelligent & solution-oriented.

Abstract: Review: Cardiovascular complications of pregnancy

Yijun Yang, Jennifer Lewey & Zoltan Arany explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions.

1Cardiovascular Institute, and.

2Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Address correspondence to: Zoltan Arany, 11th floor Smilow Translational Research Center, 34th and Civic Center Blvd, Philadelphia, Pennsylvania 19,014, USA. Email: [email protected].

Boosting the cell’s own cleanup: New class of small molecules accelerate natural protein degradation

Cells have a remarkable housekeeping system: Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular “tag” and dismantled in the cellular recycling machinery. This process, known as the ubiquitin-proteasome system, is crucial for health and survival.

Now, an international team of scientists led by CeMM, AITHYRA and the Max Planck Institute of Molecular Physiology in Dortmund has identified a new class of small molecules that harness this natural system to accelerate the removal of an immune-modulating enzyme called IDO1.

The findings, published in Nature Chemistry, introduce a new concept in drug discovery that could transform how we target difficult proteins in cancer and beyond.

Sierra Space Completes First Nine Satellite Structures for the Space Development Agency’s Tranche 2 Tracking Layer, Three Months Ahead of Schedule

Milestone accelerates progress toward delivering advanced missile tracking capabilities for the Proliferated Warfighter Space Architecture.

LOUISVILLE, Colo. – January 6, 2026 – Sierra Space, a proven defense-tech company delivering solutions for the nation’s most critical missions and advancing the future of security in space, announced today the completion of the first nine satellite structures, Plane 1 of the 18 total satellites Sierra Space is contracted to deliver for the Space Development Agency’s (SDA) Tranche 2 Tracking Layer (T2TRK) program. Achieved three months ahead of schedule, this milestone underscores Sierra Space’s ability to meet key program milestones with efficiency and precision, helping to ensure that the T2TRK program remains on track for delivery and launch readiness.

“We stood up our high-rate manufacturing facility, Victory Works, to meet the demanding requirements of our customer,” said Erik Daehler, Senior Vice President of Sierra Space Defense. “To go from a successful Critical Design Review to completing the Plane 1 satellite structures—three months ahead of schedule—is a powerful validation of our investment in scalable infrastructure. Our team is energized as we move into the next phase of Plane 1 development, focusing on assembly, integration, and testing, while also beginning the satellite structure build for Plane 2, the remaining nine satellites of the 18-satellite constellation for SDA.”

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