A 4D AI model uses mitochondrial shape and movement to predict how drugs affect cells, potentially speeding up drug discovery. [ https://www.labroots.com/trending/biotech-and-pharma/31081/4…-effects-2](https://www.labroots.com/trending/biotech-and-pharma/31081/4…-effects-2)
How can AI be used to improve drug discovery and delivery? This is what two recent studies published in Cell hopes to address as a team of researchers investigated a new method for delivering drugs to mitochondria, with mitochondria often being dubbed as the “powerhouse” of the cell. This study has the potential to help scientists, medical professionals, and the public better understand new methods for drug discovery and delivery and how it can improve patient lives.
For the studies, which were published in July 2026 and September 2026, respectively, the researchers used a combination of deep-learning AI models and 4D movies created from a novel method called 4D lattice light-sheet microscopy to ascertain how mitochondria behave when it’s healthy and not. The method of 4D lattice light-sheet microscopy involves imaging 3D movement and behavior of mitochondria over time. The primary motivation behind the study was to create new methods for studying mitochondria, which traditionally were studied using 2D snapshots.
In the end, and in one study, the researchers successfully created digital models of mitochondria, which they dubbed “digital twins”, to analyze how the mitochondria behaved compared to real cells. For the other study, the researchers and used the AI model to observe about 40,000 4D movies showing drug-treated cells to analyze how the mitochondria reacted.