LigandForge generates 150,000 peptide drug candidates in 3 minutes — a million times faster than existing methods, unlocking a tsunami of possible treatments.
A man with no medical background used ChatGPT, AlphaFold, and Grok to design a custom mRNA cancer vaccine for his dying dog — and her biggest tumor shrank 75%.
Meanwhile, scientists discovered a single protein that literally spreads aging through your bloodstream. These stories are each incredible on their own. But the big story is the implications for curing aging.
In this deep dive, I break down how these three breakthroughs fit together, what peptides and mRNA vaccines actually are (and how they’re different), and why this moment might be the most important inflection point in the history of drug design.
The age of custom AI cures isn’t coming. It’s here.
Evidence of some of the earliest dogs has been identified at two University of Liverpool/British Institute at Ankara archaeological excavation projects in central Anatolia, Turkey. Shedding new light on the development and spread of early domestic dogs, the findings are documented in twopapers published in Nature.
Providing fascinating insights into dogs’ relationships with people and their rapid spread across Europe and Anatolia, the work involved zooarchaeologists from University College London, University of Liverpool and based in Turkey and ancient DNA and isotope teams from the Natural History Museum, the Universities of Oxford and York, the Francis Crick Institute, and LMU Munich.
Two of the key excavation sites used are led by the University of Liverpool’s Professor Douglas Baird—Pınarbaşı excavated with Karaman museum and Boncuklu excavated with co-directors Professor Fairbairn, University of Queensland and Associate Professor Mustafaoĝlu, Ankara Hacı Bayram Veli University. Together, the sites span the transition from the Epipaleolithic (latest Paleolithic) to early Neolithic dated 16,000 to 10,000 years ago.
Atheist philosopher Graham Oppy is asked what it would take for him to believe in God. Watch his debate with Christian convert Guillaume Bignon here: https://www.thebigconversation.show/v…
Dr. Graham Oppy, perhaps academia’s leading atheist philosopher of religion, joins me to analyze a newly proposed argument for God’s existence: the argument from psychophysical harmony.
What does it take to keep water in a landscape that’s slowly forgetting how to hold it? Heliox investigates the drought that stunned a Canadian rainforest — and the ancient, low-tech, furry solution that gray infrastructure couldn’t match. A deep dive into watershed science, ecological restoration, and the surprising return of North America’s original hydraulic engineers.
Scientists have developed a breakthrough “superfood” for honeybees by engineering yeast to produce the essential nutrients normally found in pollen. In controlled trials, colonies fed this specially designed diet produced up to 15 times more young, showing a dramatic boost in reproduction and overall health. As climate change and modern agriculture reduce the availability of natural pollen, this innovation could offer a practical way to support struggling bee populations.
Civilizations at the end of time—how intelligence could survive heat death, cosmic isolation, entropy, and the universe’s longest future eras. Take back your personal data with Incogni! Use code isaacarthur at the link below and get 60% off annual plans: https://incogni.com/isaacarthur.
🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Civilizations at the End of Time — How Intelligence Survives the Death of the Universe Written, Produced & Narrated by: Isaac Arthur Script Editors: Andy Popescu, Briana Brownell, Connor Hogan, Darius Said, David McFarlane, Edward Nardella, Eustratius Graham, Gregory Leal, Jefferson Eagley, Keith Blockus, Konstantin Sokerin, Luca de Rosa, Ludwig Luska, Lukas Konecny, Michael Gusevsky, Mitch Armstrong, MolbOrg, Naomi Kern, Philip Baldock, Sigmund Kopperud, Steve Cardon, Tiffany Penner, Yamagishi Graphics Courtesy of: Edward Nardella, Jakub Grygier, Jarred Eagley, Jeremy Jozwik, Justin Dixon, Katie Byrne, Ken York of YD Visual, LegionTech Studios, Mafic Studios, Misho Yordanov, Murat Mamkegh, Pierre Demet, Sergio Botero, Stefan Blandin, Udo Schroeter, and Select imagery/video supplied by Getty Images Music Courtesy of: AJ Prasad, Chris Zabriskie, Dan McLeod, NeptuneUK, Lombus, Markus Junnikkala, Miguel Johnson, Phase Shift, Stellardrone, Taras Harkavyi, and Epidemic Sound: http://nebula.tv/epidemic & Stellardrone Chapters 0:00 Intro 7:11 Eternal Intelligence 49:09 Incogni 50:30 Choosing the Long Night 55:24 The Last Planet 1:27:35 When Survival Stops Being Local 1:32:38 The Omega Point 2:05:18 Big Crunch Revisited — Uncertainty Returns 2:11:09 Iron Stars 2:51:05 The Big Slurp & Vacuum Decay 2:58:23 The Big Rip 3:32:13 After the End of Time — Quantum Resurrection & Poincare Recurrence 3:34:25 Galileo. 🌐 Visit our Website: http://www.isaacarthur.net. ❤️ Support us on Patreon: / isaacarthur. ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1583992725237264 📣 Reddit Community: / isaacarthur. 🐦 Follow on Twitter / X: / isaac_a_arthur. 💬 SFIA Discord Server: / discord. Credits: Civilizations at the End of Time — How Intelligence Survives the Death of the Universe. Written, Produced & Narrated by: Isaac Arthur. Script Editors: Andy Popescu, Briana Brownell, Connor Hogan, Darius Said, David McFarlane, Edward Nardella, Eustratius Graham, Gregory Leal, Jefferson Eagley, Keith Blockus, Konstantin Sokerin, Luca de Rosa, Ludwig Luska, Lukas Konecny, Michael Gusevsky, Mitch Armstrong, MolbOrg, Naomi Kern, Philip Baldock, Sigmund Kopperud, Steve Cardon, Tiffany Penner, Yamagishi. Graphics Courtesy of: Edward Nardella, Jakub Grygier, Jarred Eagley, Jeremy Jozwik, Justin Dixon, Katie Byrne, Ken York of YD Visual, LegionTech Studios, Mafic Studios, Misho Yordanov, Murat Mamkegh, Pierre Demet, Sergio Botero, Stefan Blandin, Udo Schroeter, and Select imagery/video supplied by Getty Images. Music Courtesy of: AJ Prasad, Chris Zabriskie, Dan McLeod, NeptuneUK, Lombus, Markus Junnikkala, Miguel Johnson, Phase Shift, Stellardrone, Taras Harkavyi, and Epidemic Sound: http://nebula.tv/epidemic & Stellardrone.
Chapters. 0:00 Intro. 7:11 Eternal Intelligence. 49:09 Incogni. 50:30 Choosing the Long Night. 55:24 The Last Planet. 1:27:35 When Survival Stops Being Local. 1:32:38 The Omega Point. 2:05:18 Big Crunch Revisited — Uncertainty Returns. 2:11:09 Iron Stars. 2:51:05 The Big Slurp & Vacuum Decay. 2:58:23 The Big Rip. 3:32:13 After the End of Time — Quantum Resurrection & Poincare Recurrence. 3:34:25 Galileo
A new study from the University of Geneva points to the brain’s waste-clearance system — the glymphatic system — as a possible piece of the psychosis puzzle. In people with 22q11.2 deletion syndrome, a high-risk genetic condition, researchers found developmental differences in an MRI-derived marker linked to glymphatic function, along with associations to hippocampal excitation/inhibition balance and psychosis vulnerability.
A team from UNIGE shows that early alterations in the brain’s clearance system could contribute to vulnerability to psychosis.
How can we explain the onset of psychotic symptoms characteristic of schizophrenia? Despite their major and often irreversible impact on intellectual abilities and autonomy, the biological mechanisms that precede their emergence remain poorly understood. A team from the Department of Psychiatry at the Faculty of Medicine and the Synapsy Center for Neuroscience Research in Mental Health at the University of Geneva (UNIGE) provides new insight into this question. Early dysfunction of the glymphatic system, the network responsible for removing waste from the brain, could be a key vulnerability factor. This research has been published in Biological Psychiatry: Global Open Science.
Hallucinations and delusions are among the characteristic psychotic symptoms of schizophrenia spectrum disorders, which may also be accompanied by social withdrawal and cognitive decline. These disorders, considered neurodevelopmental conditions, most often emerge during adolescence or early adulthood and have an estimated prevalence of 0.5–3% in the general population.
Quantum computers, systems that process information leveraging quantum mechanical effects, could outperform classical computers on some advanced tasks. These systems rely on qubits, the fundamental units of quantum information, that become linked via an effect known as quantum entanglement and share a unified quantum state.
Qubits are known to be highly sensitive to slight changes or disturbances in their surrounding environment, also referred to as noise. Noise can prompt them to lose quantum information via a process called decoherence, which in turn leads to errors.
In recent years, quantum scientists and engineers have introduced various approaches aimed at mitigating or correcting quantum errors, with the goal of realizing fault-tolerant quantum computing. Some of these approaches rely on so-called erasure qubits, qubits whose errors are easier to detect and locate in real time.
