Haynes et al. report a daily, sleep-dependent neuron–glia lipid metabolic cycle. ApoE-dependent lipid transfer from neurons to glia protects neurons from oxidative damage during waking, and lipids are cleared from glia during sleep.
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Physiologic Pacing in Heart Failure
Cardiac physiologic pacing, also known as cardiac resynchronization therapy, is indicated in patients with heart failure, reduced left ventricular ejection fraction (LVEF) of 50% or less, and either a high (or anticipated high) ventricular pacing burden or a wide QRS complex. Traditionally, physiologic pacing has been achieved with biventricular pacing with a right ventricular lead and a coronary sinus branch lead. Randomized trials involving more than 10,000 patients with heart failure have shown clinical, exercise, and quality-of-life benefits associated with biventricular pacing, as well as improved LVEF and reduced mitral regurgitation and ventricular volumes. These benefits are greatest in patients with left bundle-branch block and a QRS duration of 150 msec or longer.
Do We Actually Live Inside a Black Hole? Let’s Explore the Evidence
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Hello and welcome! My name is Anton and in this video, we will talk about the claims that we live inside a black hole.
Links:
https://en.wikipedia.org/wiki/Black_hole_cosmology.
https://arxiv.org/pdf/2505.23877
https://arxiv.org/pdf/1910.10819v2
#blackhole #unvierse #astronomy.
0:00 Is universe basically a black hole?
1:10 Defining a black hole and the universe.
2:30 How would universe end up inside a black hole?
5:00 Explanations for how this may work.
6:35 Rotation and angular momentum.
8:05 What this could explain.
9:35 Counter evidence and why it’s probably not a black hole.
13:00 Rotation explanation using the cosmic web.
14:00 Conclusions.
Enjoy and please subscribe.
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Biomimetic multimodal tactile sensing enables human-like robotic perception
Robots That Feel: A New Multimodal Touch System Closes the Gap with Human Perception.
In a major advance for robotic sensing, researchers have engineered a biomimetic tactile system that brings robots closer than ever to human-like touch. Unlike traditional tactile sensors that detect only force or pressure, this new platform integrates multiple sensing modalities into a single ultra-thin skin and combines it with large-scale AI for data interpretation.
At the heart of the system is SuperTac, a 1-millimeter-thick multimodal tactile layer inspired by the multispectral structure of pigeon vision. SuperTac compresses several physical sensing modalities — including multispectral optical imaging (from ultraviolet to mid-infrared), triboelectric contact sensing, and inertial measurements — into a compact, flexible skin. This enables simultaneous detection of force, contact position, texture, material, temperature, proximity and vibration with micrometer-level spatial precision. The sensor achieves better than 94% accuracy in classifying complex tactile features such as texture, material type, and slip dynamics.
However, the hardware alone isn’t enough: rich, multimodal tactile data need interpretation. To address this, the team developed DOVE, an 8.5-billion-parameter tactile language model that functions as a computational interpreter of touch. By learning patterns in the high-dimensional sensor outputs, DOVE provides semantic understanding of tactile interactions — a form of “touch reasoning” that goes beyond raw signal acquisition.
From a neurotech-inspired perspective, this work mirrors principles of biological somatosensation: multiple receptor types working in parallel, dense spatial encoding, and higher-order processing for perceptual meaning. Integrating rich physical sensing with model-based interpretation is akin to how the somatosensory cortex integrates mechanoreceptor inputs into coherent percepts of texture, shape and motion. Such hardware-software co-design — where advanced materials, optics, electronics and AI converge — offers a pathway toward embodied intelligence in machines that feel and interpret touch much like biological organisms do.
Biomimetic multimodal tactile sensing enables human-like robotic perception.
Utility of Stereoelectroencephalography in the Treatment of Drug-Resistant Epilepsy
About one-third of people with epilepsy have drug-resistant disease—but surgery can be transformative. Drs Ihnen & Arya at Cincinnati Children’s explore how SEEG is reshaping presurgical evaluation in DRE. https://ow.ly/M15c50Y0Y0W
Epilepsy society american epilepsy society epilepsy foundation of america.
DRE can be effectively treated with epilepsy surgery, leading to seizure freedom in appropriately selected individuals.
Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory
Scientists have mapped out an importin-based pathway that enables neurons to maintain synaptic plasticity and spatial memory despite their unusually elongated shape.
Read more in ScienceSignaling.
Axonal localization of importin β1 is required for presynaptic functions that support spatial memory tasks.
New twist on BRCA1-mediated DNA recombination repair and tumor suppression
BRCA1-mediated DNA recombination repair and tumor suppression.
BRCA1 is dispensable for end resection at replication-coupled double-strand breaks (DSBs) but stimulates processing of replication-independent DSBs.
BRCA1 promotes RAD51 assembly downstream of end resection.
Canonical BRCA1/RAD51-dependent homologous recombination is essential for tumor suppression.
Loss of 53BP1 enables alternative BRCA1-independent RAD51 assembly.
Alternative BRCA1-independent RAD51 assembly supports tissue development but is not sufficient for tumor suppression. sciencenewshighlights ScienceMission https://sciencemission.com/BRCA1-mediated-DNA-recombination-repair
Are your memories illusions? New study disentangles the Boltzmann brain paradox
In a recent paper, SFI Professor David Wolpert, SFI Fractal Faculty member Carlo Rovelli, and physicist Jordan Scharnhorst examine a longstanding, paradoxical thought experiment in statistical physics and cosmology known as the “Boltzmann brain” hypothesis—the possibility that our memories, perceptions, and observations could arise from random fluctuations in entropy rather than reflecting the universe’s actual past. The work is published in the journal Entropy.
The paradox arises from a tension at the heart of statistical physics. One of the central pillars of our understanding of the time-asymmetric second law of thermodynamics is Boltzmann’s H theorem, a fundamental concept in statistical mechanics. However, paradoxically, the H theorem is itself symmetric in time.
That time-symmetry implies that it is, formally speaking, far more likely for the structures of our memories, perceptions, and observations to arise from random fluctuations in the universe’s entropy than to represent genuine records of our actual external universe in the past. In other words, statistical physics seems to force us to conclude that our memories might be spurious—elaborate illusions produced by chance that tell us nothing about what we think they do. This is the Boltzmann brain hypothesis.