A motif in antigen receptors maintains basal signaling of the small GTPase R-RAS2 in lymphocytes.
Chromatin, the mix of DNA and protein that houses each cell’s genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by researchers at King’s College London.
Scientists believe this may reveal how the body can cope with the inevitable “wear-and-tear” of aging and where it may be more vulnerable to its effects, laying the groundwork for future anti-aging treatments throughout the body.
Proteins, much like the rest of the body, change when aging. This is especially the case for the histone proteins that make up chromatin, which may “live” for ~100 days before being replenished and replaced. During their lifetime, proteins are stretched and distorted, or experience processes that are similar to rusting. This damage results in naturally occurring chemical changes to the protein called post-translational modifications, or PTMs.
This image shows the three-dimensional genome structures of several chromosomes reported in a Dip-C study, which were used to train the new ChromoGen model.
The research team, led by Professor Tobin Filleter, has engineered nanomaterials that offer unprecedented strength, weight, and customizability. These materials are composed of tiny building blocks, or repeating units, measuring just a few hundred nanometers – so small that over 100 lined up would barely match the thickness of a human hair.
The researchers used a multi-objective Bayesian optimization machine learning algorithm to predict optimal geometries for enhancing stress distribution and improving the strength-to-weight ratio of nano-architected designs. The algorithm only needed 400 data points, whereas others might need 20,000 or more, allowing the researchers to work with a smaller, high-quality data set. The Canadian team collaborated with Professor Seunghwa Ryu and PhD student Jinwook Yeo at the Korean Advanced Institute of Science & Technology for this step of the process.
This experiment was the first time scientists have applied machine learning to optimize nano-architected materials. According to Peter Serles, the lead author of the project’s paper published in Advanced Materials, the team was shocked by the improvements. It didn’t just replicate successful geometries from the training data; it learned from what changes to the shapes worked and what didn’t, enabling it to predict entirely new lattice geometries.
*First broadcast on April 11, 2024. After a slow start, Japanese washing machines have become some of the most advanced in the world. We look at their development and the latest innovations.
SoftBank is negotiating a $500 million investment in Skild AI, a software company building a foundational model for robotics at a $4 billion valuation, Bloomberg and Financial Times reported.
The 2-year-old company raised its previous funding round of $300 million at a $1.5 billion valuation last July from investors, including Jeff Bezos, Lightspeed Venture Partners, and Coatue Management.
The company’s AI model can be applied to various types of robots, Skild founders Deepak Pathak and Abhinav Gupta told TechCrunch last July. They said the generalized model can be modified for a specific domain and use case.
A study found that Streptococcus anginosus, a common mouth and gut bacterium, is more prevalent in stroke patients and linked to higher stroke risk and mortality. Streptococcus anginosus, a bacterium commonly found in the mouth and gastrointestinal tract, may be present in high levels in the gut.
Engineers have developed SUPER, a high-speed MAV, using 3D LiDAR and AI for real-time obstacle avoidance, cutting failure rates 35.9 times.
Researchers from Stanford University are working on solar panel technology that works at night, which is one of the biggest challenges of solar power.
In the face of seabeds becoming valuable real estate and corroding bombs polluting the oceans, teams are turning to technology to clean up this dangerous and expensive problem.