Lifeboat Foundation

Neurologic immune-related adverse events (nirAEs) following immune checkpoint inhibitor therapy for cancer are frequent and varied; a recent study identified risk factors for death after nirAEs.

Recent cohort studies have demonstrated that neurologic immune-related adverse events (nirAEs) following immune checkpoint inhibitor (ICI) therapy for cancer are frequent, varied, and associated with higher overall survival (NEJM JW Neurol Sep 29 2023 and Neurology 2023; 101:e2472). Researchers conducted a retrospective cohort study of consecutive patients referred to a tertiary center during a 5-year period to characterize the clinical features of nirAEs and identify predictors of ICI response and survival.

The researchers identified 64 patients with confirmed nirAEs, 81% involving the central nervous system (CNS). The vast majority of CNS nirAE patients had encephalopathy, of which 73% were neither seropositive for well-characterized neural autoantibodies, nor had a distinctive encephalitis syndrome, nor had evidence of CNS inflammatory changes. The most common peripheral nervous system (PNS) syndrome was myasthenia and myositis (with or without myocarditis) overlap syndrome. Only 17% of PNS nirAE patients were seropositive. Steroids were given to 91% of nirAE patients after a median of 90 days of symptoms, and 48% received additional immunotherapy. At 1-month follow-up, 72% of nirAE patients showed improvement, 9% had worsened, and 17% had died. Among the 53 patients who survived the first month, median follow-up was 6 months; during follow-up, 30% died, most commonly of cancer progression or cancer-related complications. Death was associated with lung cancer (hazard ratio, 2.

Continue reading “Risk Factors for Death After Neurologic Immune-Related Adverse Events” »

Talk by Ken Dickerson, CRISPR Group Leader, CRISPR QC, at the BACE Technology Showcase event in August 2022.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, potentially fatal condition caused when bloodclots in the lungs block blood vessels to the heart. Yale PCCSM’s Phillip Joseph, MD, and Yale Cardiac Surgery’s Prashanth Vallabhajosyula, MD, share how Yale’s highly specialized #

Clinicians diagnose and treat CTEPH.

The UK’s high-powered DragonFire laser weapon just shot down its first drones — bringing it one step closer to the battlefield.

Completing the commissioning maneuver that demonstrated the performance of the main engine, which will be used to place the spacecraft into lunar orbit and, later, land on the moon, was a major milestone for the mission.

“Once we get through that and we know how the engine performs in space, I think our confidence actually goes up that we will have a successful landing on the moon,” Trent Martin, vice president of space systems at Intuitive Machines, said of that engine test in a Feb. 12 interview.

The IM-1 mission is carrying six NASA payloads as part of the agency’s Commercial Lunar Payload Services (CLPS) program under a $118 million task order. It is also carrying six payloads for other customers, ranging from Embry-Riddle Aeronautical University to the artist Jeff Koons.

Live Science spoke with Šikšnys about what it’s been like to see CRISPR enter clinical use and how he thinks the system might be applied and improved upon in the future.

Editor’s Note: This interview has been condensed and edited for clarity.

Related: Gene therapy: What is it and how does it work?

Sun Bear, an enormous solar and battery storage installation in the Four Corners region of Colorado, will have more than two million solar panels spread across 5,500 acres of land belonging to the Ute Mountain Ute Tribe, part of the Weenuche Band of the Ute Nation. The primary developer is the Canigou Group, which styles itself as a global leader in renewable energy. “We are active throughout Europe, Australia and North America where we work with partners at the local level to provide a holistic solution,” it says on its website. The Sun Bear facility will cost up to $1.5 billion and produce peak power of 975 MW. There is no information currently available about the size of the battery storage system or who will supply the batteries for it.

There are several reasons why the site in southwest Colorado, which borders New Mexico, Arizona, and Utah, was chosen for this large scale solar project. Carigou Group says “Sun Bear is well positioned for harnessing the sun with its large unobstructed sky, high annual solar irradiance, and low seasonal variability. The site is located close to a confluence of transmission systems which provide access to customers via both transmission and distribution interconnection.”

Continue reading “Sun Bear Solar Farm Will Be Eight Miles Long, One Mile Wide, And Have Two Million Solar Panels” »

When the Chicxulub impactor, a six-mile-wide asteroid, struck Earth 66 million years ago, the dinosaurs had no warning.

If an asteroid that size hit Earth today, a shock wave two million times more powerful than a hydrogen bomb would flatten forests and trigger tsunamis. A seismic pulse equal to a magnitude 10 earthquake would crumble cities.

And long after the impact, a cloud of hot dust, ash, and steam would blot out the sun, plunging the Earth into freezing cold.

A coalition of international law enforcement agencies, including the FBI and UK National Crime Agency, said they have disrupted LockBit, one of the most prolific hacker groups of all time, including shutting down websites the organization used for ransomware payments.