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The global proliferation of antibiotic resistance genes (ARGs) poses a significant threat to the efficacy of antibiotic-based treatments for diseases. Effective monitoring of ARGs across both spatial and temporal dimensions is essential to understanding their transmission and implementing preventive measures.

A research team has developed a computational tool, Argo, designed to accurately track ARGs in environmental samples, providing insights into their dissemination and associated risks.

“Short-read sequencing method is currently used as a high-throughput DNA sequencing technique that generates large volumes of short DNA fragments, typically 150 base pairs. However, it often fails to provide information on the hosts of ARGs,” explained the senior author. “Without detailed host information, it becomes challenging to accurately assessing the risks of ARGs and tracing their transmission, hindering our understanding of their impact on human health and the environment.”

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This week, researchers uncovered the negative pressure mechanisms plants use to communicate stress. Linguists found that the melody of spoken language in English functions as its own, distinct language. And there was also depressing news! Like the Trump administration slashing NASA’s budget, which could scrap the James Webb Space Telescope right at the beginning of its operational life (they’re also pushing to scrap the completed Nancy Grace Roman Space Telescope before its launch).

Additionally, researchers found that the video game Dark Souls has positive psychological effects on players; a physicist made a new contribution to the theory that the universe is a computational process; and scientists in Spain mapped the brain connectivity patterns of psychosis patients:

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It’s no secret that our waistlines often expand in middle age, but the problem isn’t strictly cosmetic. Belly fat accelerates aging and slows down metabolism, increasing our risk for developing diabetes, heart problems and other chronic diseases. Exactly how age transforms a six pack into a softer stomach, however, is murky.

Now preclinical research by City of Hope has uncovered the cellular culprit behind age-related abdominal fat, providing new insights into why our midsections widen with middle age.

Published today in Science, the findings suggest a novel target for future therapies to prevent belly flab and extend our healthy lifespans.

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In recent years, cell therapies have developed alongside chemotherapy and immunotherapy to become a new pillar in the treatment of patients with blood and lymph gland cancer. In solid tumors, such as skin, lung, or bone and soft tissue cancer (sarcomas), they have not yet proven themselves as a treatment method.

Tumor shrinkage was achieved only in rare cases, but the side effects were all the more severe. An international research group led by scientists from the National Center for Tumor Diseases (NCT/UCC) in Dresden has now conducted a Phase I clinical trial of a novel cell therapy approach that also shows promise for .

The results are published in Nature Medicine.

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Virginia Tech researchers discovered six new rodent carriers of hantavirus and identified U.S. hotspots, highlighting the virus’s adaptability and the impact of climate and ecology on its spread. Hantavirus recently drew public attention following reports that it was the cause of death for Betsy

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In a world-first, scientists have figured out how to reprogram cells to fight — and potentially reverse — brain diseases like Alzheimer’s.

Researchers at the University of California, Irvine created lab-grown immune cells that can track down toxic brain buildup and clear it away, restoring memory and brain function in mice.

They did this by turning stem cells — which can become any cell in the body — into brain immune cells called microglia.

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Colorectal cancer rates are rising among younger Americans — the reason behind the jump has become hard for scientists to identify, but the symptoms to watch out are known. Colorectal cancer, which encompasses colon and rectal cancer, is the second leading cause of all cancer-related deaths in the U.S. Last year saw a slight increase in deaths, with just over 53,000 reported. There were also nearly 153,000 new cases of colorectal cancer, the majority of which were in men. While survival rates have improved among older Americans, the incidence rate for people under the age of 55 continues to…

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Strawberry fields forever will exist for the in-demand fruit, but the laborers who do the backbreaking work of harvesting them might continue to dwindle. While raised, high-bed cultivation somewhat eases the manual labor, the need for robots to help harvest strawberries, tomatoes, and other such produce is apparent.

As a first step, Osaka Metropolitan University Assistant Professor Takuya Fujinaga has developed an algorithm for robots to autonomously drive in two modes: moving to a pre-designated destination and moving alongside raised cultivation beds. The Graduate School of Engineering researcher experimented with an agricultural robot that utilizes lidar point cloud data to map the environment.

Official website for Osaka Metropolitan University. Established in 2022 through the merger of Osaka City University and Osaka Prefecture University.

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Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of a wheelchair. In the early stages of this rare hereditary disease, the brain appears to play a major role by over-activating the immune system, as shown by a recent study published in the Journal of Experimental Medicine.

The study was led by researchers at the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE). These findings could also be relevant for Alzheimer’s disease and other neurodegenerative conditions.

Spastic paraplegia type 15 is characterized by the progressive loss of neurons in the central nervous system that are responsible for controlling movement. Initial symptoms typically appear in late childhood, manifesting first in the legs in the form of uncontrollable twitching and paralysis.

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