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Bill Taranto — President, GHI Fund, Merck — Corporate Venturing For Integrated Healthcare Solutions

Corporate Venturing For Integrated Digital Healthcare Solutions — Bill Taranto, President, Global Health Innovation Fund, Merck


Bill Taranto is President of the Global Health Innovation Fund at Merck (https://www.merckghifund.com/taranto.html) and founding partner since inception in 2010.

Merck Global Health Innovation Fund (Merck GHI) is a corporate venture capital group utilizing a healthcare ecosystem strategy, investing globally in platform companies with proven technologies or business models where Merck’s expertise can accelerate revenue growth and enhance value creation to ultimately develop integrated healthcare solutions.

Merck GHI has $500M under management per an evergreen model and invests broadly in the domain of digital health, and other segments, and has made over 60 investments in portfolio companies, and has over 20 exits. They invest across the segments of Therapy Planning, Care Management, Health Analytics & AI, eClinical Trials and enabling technologies.

Bill has more than 30 years of health care experience including over 20 years of healthcare investing.

What constitutes a mind? Researcher challenges perceptions of sentience with the smallest of creatures

At the beginning of my research career around 15 years ago, any suggestion that a bee, or any invertebrate, had a mind of its own or that it could experience the world in an intricate and multifaceted way would be met with ridicule. As Lars Chittka points out in the opening chapters of “The Mind of a Bee,” the attribution of human emotions and experiences was seen as naivety and ignorance; anthropomorphism was a dirty word.

Pet owners eagerly ascribe emotions to their animals, but the simple brain of a bee surely could not experience the rich tapestry that is our existence. They are far too simplistic and robotic, right?

Lars Chittka has been researching honeybees for the past 30 years. “The Mind of a Bee” is a collection of his research stories. It also covers the influential figures in bee research and provides a historical perspective on the research that much behavioral work is built on today.

Engineered Cells Become Drug Factories with Avian Assistance

The genetic encoding of ncAAs with distinct chemical, biological, and physical properties requires the engineering of bioorthogonal translational machinery, consisting of an evolved aminoacyl-tRNA synthetase/tRNA pair and a “blank” codon. To achieve this, the researchers mimicked the ibis’ ability to synthesize sTyr and incorporate it into proteins.

The Xiao lab employed a mutant amber stop codon to encode the desired sulfotransferase, resulting in a completely autonomous mammalian cell line capable of biosynthesizing sTyr and incorporating it with great precision into proteins.

These engineered cells, the authors wrote, can produce “site-specifically sulfated proteins at a higher yield than cells fed exogenously with the highest level of sTyr reported in the literature.” They used the cells to prepare highly potent thrombin inhibitors with site-specific sulfation.

Just say the magic word: using language to program robots

Language is the most intuitive way for us to express how we feel and what we want. However, despite recent advancements in artificial intelligence, it is still very hard to control a robot using natural language instructions. Free-form commands such as “Robot, please go a little slower when you pass close to my TV” or “Stay far away from the swimming pool!” are hard to parse into actionable robot behaviors, and most human-robot interfaces today still rely on complex strategies such directly programming cost functions which define the desired behavior.

With our latest work, we attempt to change this reality through the introduction of “LaTTe: Language Trajectory Transformer”. LaTTe is a deep machine learning model that lets us send language commands to robots in an intuitive way with ease. When given an input sentence by the user, the model fuses it with camera images of objects that the robot observes in its surroundings, and outputs the desired robot behavior.

As an example, think of a user trying to control a robot barista that’s moving a wine bottle. Our method allows a non-technical user to control the robot’s behavior only using words, in a natural and simple interface. We will explain how we can achieve this in detail through this post.

A Robot on Mars Detected The Tremors of Meteorites Hitting The Red Planet

An instrument designed to detect seismic activity on Mars has just revealed an incredibly cool new ability, detecting faint tremors from meteorites impacting the red planet.

By combining data collected from the NASA’s Mars InSight lander with information from the Mars Reconnaissance Orbiter researchers have successfully linked those ground-shaking booms with freshly formed craters.

Not only does this help us understand the impact processes that continue to shape Martian geology, it demonstrates how collecting seismic data can reveal information beyond expected mission parameters. This may help inform future exploration of other worlds.

AI image search engine finds great prompts for Stable Diffusion and co

With the advent of generative image AI, a new discipline is emerging: prompt engineering. Search engines like Krea provide inspiration.

Prompts are the short text descriptions that an image AI like DALL-E 2, Midjourney or Stable Diffusion uses to generate an image.

Often it is difficult to put the idea you have in mind into fitting words. Moreover, the AI may execute instructions differently than you want it to. And there are plenty of modifiers, for example for image cropping or style, that can lead to very different results for the otherwise same prompt.

AI software helps bust image fraud in academic papers

Scientific publishers such as the American Association for Cancer Research (AACR) and Taylor & Francis have begun attempting to detect fraud in academic paper submissions with an AI image-checking program called Proofig, reports The Register. Proofig, a product of an Israeli firm of the same name, aims to help use “artificial intelligence, computer vision and image processing to review image integrity in scientific publications,” according to the company’s website.

During a trial that ran from January 2021 to May 2022, AACR used Proofig to screen 1,367 papers accepted for publication, according to The Register. Of those, 208 papers required author contact to clear up issues such as mistaken duplications, and four papers were withdrawn.

In particular, many journals need help detecting image duplication fraud in Western blots, which are a specific style of protein-detection imagery consisting of line segments of various widths. Subtle differences in a blot’s appearance can translate to dramatically different conclusions about test results, and many cases of academic fraud have seen unscrupulous researchers duplicate, crop, stretch, and rotate Western blots to make it appear like they have more (or different) data than they really do. Detecting duplicate images can be tedious work for human eyes, which is why some firms like Proofig and ImageTwin, a German firm, are attempting to automate the process.