Quantum mechanics is simultaneously beautiful and frustrating.
Its explanatory power is unmatched. Armed with the machinery of quantum theory, we have unlocked the secrets of atomic power, divined the inner workings of chemistry, built sophisticated electronics, discovered the power of entanglement, and so much more. According to some estimates, roughly a quarter of our world’s GDP relies on quantum mechanics.
Yet despite its overwhelming success as a framework for understanding what nature does, quantum mechanics tells us very little about how nature works. Quantum mechanics provides a powerful set of tools for successfully making predictions about what subatomic particles will do, but the theory itself is relatively silent about how those subatomic particles actually go about their lives.
QuEra Computing, maker of the world’s first and only publicly accessible neutral-atom quantum computer—Aquila—today announces its research team has uncovered a method to perform a wider set of optimization calculations than previously known to be possible using neutral-atom machines.
The findings are the work of QuEra researchers and collaborators from Harvard and Innsbruck Universities: Minh-Thi Nguyen, Jin-Guo Liu, Jonathan Wurtz, Mikhail D. Lukin, Sheng-Tao Wang, and Hannes Pichler.
“There is no question that today’s news helps QuEra deliver value to more partners, sooner. It helps bring us closer to our objectives, and marks an important milestone for the industry as well,” said Alex Keesling, CEO at QuEra Computing. “This opens the door to working with more corporate partners who may have needs in logistics, from transport and retail to robotics and other high-tech sectors, and we are very excited about cultivating those opportunities.”
In this video students of the Maastricht Science Program NanoBiology Course 2020, show their explanation of the SARS-CoV-2 viral budding. Using CellPAINT, UCFS Chimera and their creativity they explain the nanobiology of how the SARS-CoV-2 virion can bud and leave the cell.
Viruses are not living things. They are just complicated assemblies of molecules, in particular macromolecules such as proteins, oligonucleotides, combined with lipids and carbohydrates. A virus cannot function or reproduce by itself. It needs a host cell.
When a virus enters the host cell, a series of chemical reactions occur that lead to the production of new viruses. A virus needs to find a host cell, attach to it, enter it, and reprogram it such that it will replicate its genome and produce new proteins that allow the assembly of a new virus. Once new viruses have been assembled, they need to get out of the original host cell, on their way to the next host cell they can exhaust. Some viruses have an easy way out: they use up all the resource of the host cells until it dies and lyse. This would only work for naked viruses such as polyomavirus and adenovirus, which lacks a lipid membrane.
Washing hands has been a standard measure since the start of this COVID-19 pandemic. The soap will disintegrate the lipid envelop of the SARS-CoV2 viral particles, as this is an enveloped virus. Enveloped viruses need envelopment, a process in which the capsids become surrounded by a lipid bilayer. This process takes place prior to release. Two mechanisms for envelopment exist. First, envelopment can proceed sequentially after the completion of capsid assembly. The fully assembled capsids are recruited to the membrane by interaction of the viral capsids with viral envelope glycoprotein. Examples of this include herpesvirus and hepatitis B virus. Secondly, the envelopment can occur simultaneously with the capsid assembly. Retrovirus is the representative of this coupled mechanism.
Where does the membrane for the envelopment come from? Some viruses, such as retrovirus and influenza virus, using the plasma membrane as the site of envelopment, whereas others, such as herpesvirus and hepatitis B, use the endoplasmic reticulum (ER) and Golgi bodies as the site of envelopment.
Enveloped viruses are released from the infected cell via exocytosis, a process which is often also called budding. Viruses exploit cellular mechanisms to produce their own progeny extracellularly. For example, the budding of retroviral Gag is facilitated by ESCRT complexes, which are normally involved in the multi-vesicular bodies (MVB) pathway. How does SARS-CoV2 release its offspring from the infected cell? Can we interfere with these steps such that we attack the virus at each step of its life cycle?
Research in fundamental science has revealed the existence of quark-gluon plasma (QGP)—a newly identified state of matter—as the constituent of the early universe. Known to have existed a microsecond after the Big Bang, the QGP, essentially a soup of quarks and gluons, cooled down with time to form hadrons like protons and neutrons—the building blocks of all matter.
One way to reproduce the extreme conditions prevailing when QGP existed is through relativistic heavy-ion collisions. In this regard, particle accelerator facilities like the Large Hadron Collider (LHC) and the Relativistic Heavy Ion Collider have furthered our understanding of QGP with experimental data pertaining to such collisions.
Meanwhile, theoretical physicists have employed multistage relativistic hydrodynamic models to explain the data, since the QGP behaves very much like a perfect fluid. However, there has been a serious lingering disagreement between these models and data in the region of low transverse momentum, where both the conventional and hybrid models have failed to explain the particle yields observed in the experiments.
Quantum Mechanics is the science behind nuclear energy, smart phones, and particle collisions. Yet, almost a century after its discovery, there is still controversy over what the theory actually means. The problem is that its key element, the quantum-mechanical wave function describing atoms and subatomic particles, isn’t observable. As physics is an experimental science, physicists continue to argue over whether the wave function can be taken as real, or whether it is just a tool to make predictions about what can be measured—typically large, “classical” everyday objects.
The view of the antirealists, advocated by Niels Bohr, Werner Heisenberg, and an overwhelming majority of physicists, has become the orthodox mainstream interpretation. For Bohr especially, reality was like a movie shown without a film or projector creating it: “There is no quantum world,” Bohr reportedly affirmed, suggesting an imaginary border between the realms of microscopic, “unreal” quantum physics and “real,” macroscopic objects—a boundary that has received serious blows by experiments ever since. Albert Einstein was a fierce critic of this airy philosophy, although he didn’t come up with an alternative theory himself.
For many years only a small number of outcasts, including Erwin Schrödinger and Hugh Everett populated the camp of the realists. This renegade view, however, is getting increasingly popular—and of course triggers the question of what this quantum reality really is. This is a question that has occupied me for many years, until I arrived at the conclusion that quantum reality, deep down at the most fundamental level, is an all-encompassing, unified whole: “The One.”
One of Albert Einstein’s theory of general relativity’s most fascinating predictions is the possibility of black holes, which are created after a massive star reaches the end of its life and collapses. Supermassive black holes as big as 100,000 or ten billion times the Sun are commonly found at the center of most galaxies.
Those are the biggest form of black holes, but it is also thought that primordial black holes (PBHs) also exist. Unlike the big ones, these tiny black holes emerged in the early cosmos through the gravitational collapse of extraordinarily dense areas.
Physics gets strange at the atomic scale. Scientists are utilizing quantum analog simulators – laboratory experiments that involve cooling numerous atoms to low temperatures and examining them using precisely calibrated lasers and magnets – to uncover, harness, and control these unusual quantum effects.
Scientists hope that any new understanding gained from quantum simulators will provide blueprints for designing new exotic materials, smarter and more efficient electronics, and practical quantum computers. But in order to reap the insights from quantum simulators, scientists first have to trust them.
That is, they have to be sure that their quantum device has “high fidelity” and accurately reflects quantum behavior. For instance, if a system of atoms is easily influenced by external noise, researchers could assume a quantum effect where there is none. But there has been no reliable way to characterize the fidelity of quantum analog simulators, until now.
These tiny black holes lose mass faster than their massive counterparts, emitting Hawking radiation until they finally evaporate.
One of the most intriguing predictions of Einstein’s general theory of relativity.
When a sufficiently massive star runs out of fuel, it explodes, and the remaining core collapses, leading to the formation of a stellar black hole (ranging from 3 to 100 solar masses).
Supermassive black holes also exist in the center of most galaxies.
So far, astronomers have captured images of two supermassive black holes: one in the center of the galaxy M87 and the most recent in our Milky Way (Sagittarius A*).
But it’s believed that another kind of black hole exists – the primordial or primitive black hole (PBHs). These have a different origin to other black holes, having formed in the early universe through the gravitational collapse of extremely dense regions.
Through optomechanical experiments, scientists aim to delve into the boundaries of the quantum realm and lay the groundwork for the creation of highly sensitive quantum sensors. In these experiments, everyday visible objects are coupled to superconducting circuits through electromagnetic fields.
To produce functional superconductors, these experiments are conducted inside cryostats at a temperature of around 100 millikelvins. However, this is still far from low enough to truly enter the quantum world. In order to observe quantum effects on large-scale objects, they must be cooled to nearly absolute zero.
Absolute zero is the theoretical lowest temperature on the thermodynamic temperature scale. At this temperature, all atoms of an object are at rest and the object does not emit or absorb energy. The internationally agreed-upon value for this temperature is −273.15 °C (−459.67 °F; 0.00 K).
