Tau accumulation is associated with disease progression in Alzheimer’s disease. Here the authors use resting state fMRI and tau-PET to demonstrate that baseline connectivity in Alzheimer’s disease is associated with tau spreading.

This article is reprinted by permission from NextAvenue.org.

During the last Alzheimer’s disease support meeting I attended at my mother’s assisted living center, I sheepishly asked if anyone else was worried about their own risk for the disease.

A lot of hands went up.

Not all patients who fall into a coma return, and when they do it can mark a moment of joy for their loved ones—but their troubles are rarely over.

Often, brain damage leaves them paralysed or unable to communicate.

Belgian neurologist Steven Laureys has dedicated himself to the question of how to improve the lives of the formerly comatose, and of their families.

‘Poisoner In Chief’ Details The CIA’s Secret Quest For Mind Control Journalist Stephen Kinzer reveals how CIA chemist Sidney Gottlieb worked in the 1950s and early ’60s to develop mind control drugs and deadly toxins that could be used against enemies.

Inside a cell, tentacled vesicles shuttle cargo for sorting. DNA rearranges in the nucleus as stem cells differentiate into neurons. Neighboring neurons cling to one another through a web-like interface. And a new microscopy technique shows it all, in exquisite detail.

The technique, called cryo-SR/EM, melds images captured from electron microscopes and super-resolution light microscopes, resulting in brilliant, clear detailed views of the inside of cells—in 3D.

For years, scientists have probed the microscopic world inside cells, developing new tools to view these basic units of life. But each tool comes with a tradeoff. Light microscopy makes it simple to identify specific cellular structures by tagging them with easy-to-see fluorescent molecules. With the development of super-resolution (SR) fluorescence microscopy, these structures can be viewed with even greater clarity. But fluorescence can reveal only a few of the more than 10,000 proteins in a cell at a given time, making it difficult to understand how these few relate to everything else. Electron microscopy (EM), on the other hand, reveals all cellular structures in high-resolution pictures—but delineating one feature from all others by EM alone can be difficult because the space inside of cells is so crowded.