Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience – Page 823

Researchers from the University of Michigan Rogel Cancer Center have found that a genetic mutation seen in about half of all brain tumors produces a response that prevents radiation treatment from working. Altering that response using FDA-approved drugs restores tumors’ sensitivity to radiation therapy, extending survival in mice.

The paper, representing more than five years of research, is published in Science Translational Medicine.

“These findings have great potential to impact medical treatment of patients with low-grade glioma, which is critically needed for this terrible disease,” says senior author Maria G. Castro, Ph.D., R. C. Schneider Collegiate Professor of Neurosurgery and a professor of cell and developmental biology at Michigan Medicine.

Read more

Having a muted RSA and an elevated resting heart rate reflects a heightened state of arousal, which is an appropriate response to danger, says Amy Vaughan Van Hecke, associate professor of psychology at Marquette University in Milwaukee, Wisconsin, who was not involved in the study.

The part of the nervous system that regulates heart rate and breathing is involved in autism, a new study suggests.

Specifically, the changes in heart rate that ordinarily accompany breathing are slow to develop in autistic children.

Heart rate usually speeds up slightly as a person inhales and slows as she exhales. These fluctuations, known as respiratory sinus arrhythmia (RSA), serve as a proxy for the activity of the autonomic nervous system, which regulates heart rate and breathing, among other functions. The fluctuations are also important for regulating emotions and attending to social cues.

Continue reading “Nerves that control heart rate may contribute to autism” | >

By discovering the culprit behind decreased blood flow in the brain of people with Alzheimer’s, biomedical engineers at Cornell University have made possible promising new therapies for the disease.

You know that dizzy feeling you get when, after lying down for an extended period, you stand up a little too quickly?

That feeling is caused by a sudden reduction of blood flow to the , a reduction of around 30 percent. Now imagine living every minute of every day with that level of decreased blood flow.

Read more

“We found that lactate stimulates synaptic activity-dependent genes in the short-term and genes involved in regulating neuronal excitability in the long-term,” explains the first author of the paper Michael Margineanu, a KAUST Master’s student.

Study illustrates the links between brain energy metabolism and neuronal activity.

A genome-wide study led by Dean Pierre Magistretti sheds light on the mechanisms through which lactate regulates long-term memory formation and neuroprotection.

The breakdown of sugar in non-neuronal brain cells, called astrocytes, produces lactate, which gets shuttled to neurons as a source of energy. This lactate not only supports the energy demands of neurons, but also rapidly and transiently activates multiple genes that modulate neuronal activity and regulate brain function.

Continue reading “Lactate activates multiple genes that modulate neuronal activity” | >

Teams of researchers are developing sesame seed-size neuro-implants that detect brain activity that signals depression and then deliver targeted electrical zaps to elevate your mood. It’s very early days in the science and technology but recent studies suggest that we’re on the path. Links to scientific papers below. Fortunately, the goal is to develop tools and a methodology more precise than the horrifically blunt “shock therapy” of last century. From Science News:

Read more