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Category: neuroscience – Page 733

Stephen Wolfram is a cult figure in programming and mathematics. He is the brains behind Wolfram Alpha, a website that tries to answer questions by using algorithms to sift through a massive database of information. He is also responsible for Mathematica, a computer system used by scientists the world over.

Last week, Wolfram launched a new venture: the Wolfram Physics Project, an ambitious attempt to develop a new physics of our Universe.

The new physics, he declares, is computational. The guiding idea is that everything can be boiled down to the application of simple rules to fundamental building blocks.

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Researchers have confirmed that neuropeptide somatostatin can improve cognitive function in the brain. A research group of Professor Seung-Hee Lee from the Department of Biological Sciences at KAIST found that the application of neuropeptide somatostatin improves visual processing and cognitive behaviors by reducing excitatory inputs to parvalbumin-positive interneurons in the cortex.

This study, reported at Science Advances on April 22nd, sheds a new light on the therapeutics of neurodegenerative diseases. According to a recent study in Korea, one in ten seniors over 65 is experiencing dementia-related symptoms in their daily lives such as memory loss, cognitive decline, and motion function disorders. Professor Lee believes that somatostatin treatment can be directly applied to the recovery of cognitive functions in Alzheimer’s disease patients.

Professor Lee started this study noting the fact that the level of somatostatin expression was dramatically decreased in the cerebral cortex and cerebrospinal fluid of Alzheimer’s disease patients.

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Strokes, seizures, loss of smell and taste and other neurological deficits are showing up in patients critically ill with the coronavirus.

Although the virus is classified as a respiratory disorder and primarily damages the lungs, clinicians are seeing patients with a wide array of symptoms, from seizures to hallucinations, brain inflammation, disorientation, delirium and loss of smell and taste.

“I had a patient, a young guy, 48, who attended a party in New Rochelle two weeks before and came in with hallucinations and confusion,” said Dr. Pooia Fattahi, regional chair of neurology for Trinity Health Of New England. The patient had no fever and only a slight cough. Still, aware some COVID-19 patients show up at hospitals with seizures, strokes and confusion, Fattahi suspected, correctly, that the patient had COVID-19. Three of those who attended the same New Rochelle party ultimately died of the virus.

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Most research about the genetics of schizophrenia has sought to understand the role that genes play in the development and heritability of schizophrenia. Many discoveries have been made, but there have been many missing pieces. Now, UNC School of Medicine scientists have conducted the largest-ever whole genome sequencing study of schizophrenia to provide a more complete picture of the role the human genome plays in this disease.

Published in Nature Communications, the study co-led by senior author Jin Szatkiewicz, PhD, associate professor in the UNC Department of Genetics, suggests that rare structural genetic variants could play a role in schizophrenia.

“Our results suggest that ultra-rare structural variants that affect the boundaries of a specific genome structure increase risk for schizophrenia,” Szatkiewicz said. “Alterations in these boundaries may lead to dysregulation of gene expression, and we think future mechanistic studies could determine the precise functional effects these variants have on biology.”

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The virus is likely only to fuel the disaster preparedness industry in New Zealand and beyond. “Obviously the coronavirus is making people realize how vulnerable we all are, but what people are really concerned about is the aftermath,” said Vicino, the Vivos founder, who believes the wealthy fear an economic collapse or global depression could lead to uprisings against the top 1%. “They don’t want to have to defend their homes when the gangs of looters or marauders show up.”

Interest in New Zealand bunkers has surged.

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“Scientists have discovered an earlier origin to the human language pathway in the brain, pushing back its evolutionary origin by at least 20 million years.”

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Klotho has been called the “king of anti-aging proteins.” It is an important biomarker and promising gene therapy treatment for Chronic Kidney Disease. It is more strongly correlated with IQ than any single gene, making it a potential nootropic and intelligence enhancing gene therapy.

https://biovivascience.myshopify.com/blogs/news/klotho-queen…g-proteins

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