LifeArc scientists, in collaboration with researchers in the UK and Germany, have developed a promising new approach to potentially treat Alzheimer’s disease – and also vaccinate against it.

Both the antibody-based treatment and the protein-based vaccine developed by the team reduced Alzheimer’s symptoms in mouse models of the disease. The research is published today in Molecular Psychiatry.

LifeArc and researchers in the UK & Germany have developed a promising new approach to potentially treat Alzheimer’s.

𝙎𝙥𝙤𝙣𝙜𝙚 𝙂𝙚𝙣𝙚𝙨 𝙃𝙞𝙣𝙩 𝙖𝙩 𝙩𝙝𝙚 𝙊𝙧𝙞𝙜𝙞𝙣𝙨 𝙤𝙛 𝙉𝙚𝙪𝙧𝙤𝙣𝙨 𝙖𝙣𝙙 𝙊𝙩𝙝𝙚𝙧 𝘾𝙚𝙡𝙡𝙨

A new study of gene expression in sponges reveals the complex diversity of their cells as well as some possibly ancient connections between the nervous, immune and digestive systems.

Unusual clusters on neurons are calcium-signaling “hotspots” that activate gene transcription, allowing neurons to produce crucial proteins.

For 30 years, mysterious clusters of proteins found on the cell body of neurons in the hippocampus, a part of the brain, both intrigued and baffled James Trimmer.

Now, the distinguished professor of physiology and membrane biology at the UC Davis School of Medicine may finally have an answer. In a new study published in PNAS, Trimmer and his colleagues reveal these protein clusters are calcium signaling “hotspots” in the neuron that play a crucial role in activating gene transcription.