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Microscopy technique makes finer images of deeper tissue, more quickly

To create high-resolution, 3D images of tissues such as the brain, researchers often use two-photon microscopy, which involves aiming a high-intensity laser at the specimen to induce fluorescence excitation. However, scanning deep within the brain can be difficult because light scatters off of tissues as it goes deeper, making images blurry.

Two-photon imaging is also time-consuming, as it usually requires scanning individual pixels one at a time. A team of MIT and Harvard University researchers has now developed a modified version of two-photon imaging that can image deeper within tissue and perform the imaging much more quickly than what was previously possible.

This kind of imaging could allow scientists to more rapidly obtain high-resolution of structures such as vessels and individual neurons within the brain, the researchers say.

Researchers record brainwaves to measure ‘cybersickness’

If a virtual world has ever left you feeling nauseous or disorientated, you’re familiar with cybersickness, and you’re hardly alone. The intensity of virtual reality (VR)—whether that’s standing on the edge of a waterfall in Yosemite or engaging in tank combat with your friends—creates a stomach-churning challenge for 30–80% of users.

In a first-of-its kind study, researchers at the University of Maryland recorded VR users’ using electroencephalography (EEG) to better understand and work toward solutions to prevent cybersickness. The research was conducted by Eric Krokos, who received his Ph.D. in computer science in 2018, and Amitabh Varshney, a professor of and dean of UMD’s College of Computer, Mathematical, and Natural Sciences.

Their study, “Quantifying VR cybersickness using EEG,” was recently published in the journal Virtual Reality.

Scientists discover plant ‘brain’ controlling seed development

Circa 2017


A new study by scientists at the University of Birmingham has revealed a group of cells that function as a ‘brain’ for plant embryos, capable of assessing environmental conditions and dictating when seeds will germinate.

A plant’s decision about when to germinate is one of the most important it will make during its life. Too soon, and the plant may be damaged by harsh winter conditions; too late, and it may be out-competed by other, more precocious plants.

In a study published today in Proceedings of the National Academy of Sciences (PNAS), scientists from the University of Birmingham have shown that this trade-off between speed and accuracy is controlled by a small group of within the that operate in similar way to the human brain.

‘Time Cells’ Identified in Our Brains Encode The Flow of Time, Scientists Say

How does the human brain keep track of the order of events in a sequence?

New research suggests that ‘time cells’ – neurons in the hippocampus thought to represent temporal information – could be the glue that sticks our memories together in the right sequence so that we can properly recall the correct order in which things happened.

Evidence for these kinds of sequence-tracking time cells was previously found in rats, where specific neuron assemblies are thought to support the recollection of events and the planning of action sequences – but less is known about how episodic memory is encoded in the human brain.

Cannabinoid Pathway Linked to Psychiatric Disorders

“Cannabis may contribute to increased risk for mental disorders, which has actually been shown in schizophrenia,” Penzes said. “Conversely, cannabis could be beneficial in some brain disorders, which prompted trials of medical marijuana in patients with autism.”


Summary: Findings reveal a role the endocannabinoid system plays in a range of psychiatric disorders, including schizophrenia, bipolar disorder, and ASD.

Source: Northwestern University

Northwestern Medicine scientists discovered an unexpected connection between a synapse protein that has been implicated in neuropsychiatric disorders and the endocannabinoid pathway, according to a study published in Biological Psychiatry.

These findings suggest a role for the endocannabinoid system in conditions including bipolar disorder, according to Peter Penzes, PhD, the Ruth and Evelyn Dunbar Professor of Psychiatry and Behavioral Sciences, professor of Physiology and Pharmacology, and senior author of the study.

A noninvasive technique for neurological conditions

Indiana University School of Medicine researchers are developing a new, noninvasive brain stimulation technique to treat neurological disorders, including pain, traumatic brain injury (TBI), epilepsy, Parkinson’s disease, Alzheimer’s disease and more.

“Given the increasing use of stimulation in human brain study and treatment of neurological diseases, this research can make a big impact on physicians and their patients,” said Xiaoming Jin, Ph.D., associate professor of anatomy, cell biology and physiology.

When someone experiences a , nerve injury, or neurodegeneration, such as in epilepsy and TBI, there is damage to the brain which can lead to loss and damage of nerve or neurons and development of hyperexcitability that underlies some neurological disorders such as neuropathic pain and epilepsy.

Stem cell-based biological tooth repair and regeneration

Stem cells for teeth repair.


Teeth exhibit limited repair in response to damage, and dental pulp stem cells probably provide a source of cells to replace those damaged and to facilitate repair. Stem cells in other parts of the tooth, such as the periodontal ligament and growing roots, play more dynamic roles in tooth function and development. Dental stem cells can be obtained with ease, making them an attractive source of autologous stem cells for use in restoring vital pulp tissue removed because of infection, in regeneration of periodontal ligament lost in periodontal disease, and for generation of complete or partial tooth structures to form biological implants. As dental stem cells share properties with mesenchymal stem cells, there is also considerable interest in their wider potential to treat disorders involving mesenchymal (or indeed non-mesenchymal) cell derivatives, such as in Parkinson’s disease.

Teeth are complex organs containing two separate specialized hard tissues, dentine and enamel, which form an integrated attachment complex with bone via a specialized (periodontal) ligament. Embryologically, teeth are ectodermal organs that form from sequential reciprocal interactions between oral epithelial cells (ectoderm) and cranial neural crest derived mesenchymal cells. The epithelial cells give rise to enamel forming ameloblasts, and the mesenchymal cells form all other differentiated cells (e.g., dentine forming odontoblasts, pulp, periodontal ligament) (Box 1). Teeth continue developing postnatally; the outer covering of enamel gradually becomes harder, and root formation, which is essential for tooth function, only starts to occur as part of tooth eruption in children.

Tooth development is traditionally considered a series of stages that reflect key processes ( Figure I ). The first step is induction, in which signals from the epithelium to the mesenchyme initiate the developmental process. As localized proliferation of the dental epithelial cells takes place, the cells form a bud around which the mesenchymal cells condense. Differentiation and localized proliferation of the epithelial cells in the bud leads to the cap stage. It is at this stage that crown morphogenesis is initiated by the epithelial signalling centre, an enamel knot regulating the folding of the epithelium. By the bell stage, the precursors of the specialized tooth cells, ameloblasts, coordinate enamel deposition, and odontoblasts, which produce dentine, are formed. Tooth eruption involves the coordination of bone resorption and root development, and occurs postnatally.

Dr. Maria Millan, MD — President and CEO — California Institute for Regenerative Medicine (CIRM)

US$8.5 Billion In Funding — 150+ Projects


Dr. Maria Millan, MD, is the President and CEO of the California Institute for Regenerative Medicine (CIRM — https://www.cirm.ca.gov/), an organization that was created in 2004 when voters initially approved a state Proposition which allocated US$3 billion to fund this fascinating area of medicine, and which recently received an additional US$5.5 billion in renewed funding.

Dr. Millan is a physician-scientist who has devoted her career to treating and developing innovative solutions for children and adults with debilitating and life-threatening conditions.

After receiving her undergraduate degree from Duke University where she started her focus on immunology research, Dr. Millan obtained her MD degree and then went on to complete her surgical training and post-doctoral research at Harvard Medical School – Beth Israel Deaconess Medical Center.

After a transplant surgery fellowship at Stanford University School of Medicine, Dr. Millan began her academic career with a pediatric and adult transplant surgery practice. In parallel, she continued her bench research at Stanford and became associate professor and director of the Pediatric Organ Transplant Program.

Predicting new major depression symptoms from long working hours, psychosocial safety climate and work engagement: a population-based cohort study

Objectives This study sought to assess the association between long working hours, psychosocial safety climate (PSC), work engagement (WE) and new major depression symptoms emerging over the next 12 months. PSC is the work climate supporting workplace psychological health.

Setting Australian prospective cohort population data from the states of New South Wales, Western Australia and South Australia.

Participants At Time 1, there were 3921 respondents in the sample. Self-employed, casual temporary, unclassified, those with working hours 35 (37% of 2850) and participants with major depression symptoms at Time 1 (6.7% of 1782) were removed. The final sample was a population-based cohort of 1084 full-time Australian employees.