Lifeboat Foundation

Klotho, named after one of the Fates of Greek mythology, is the queen of anti-aging proteins. There are no close contenders at this time. Klotho gene therapy, like the one offered by Integrated Health Systems, has tremendous benefits. While it is produced primarily in the kidneys and brain, its soluble form circulates throughout the body. Many of the investigations so far have been done nephrologists interested in its prominent role in Chronic Kidney Disease (CKD), yet over the last decade its multifaceted role in the aging process has become a topic of intense research.

Klotho deficient mice show premature aging in multiple organs.

Inducing KL overexpression with a viral vector, like AAV, not only reverses this premature aging, but also enhances resistance to oxidative and ischemic damage. More impressive, KL outright extends the lifespans of mice, likely be inhibiting IGF and insulin signalling. Dubbed an “aging suppressor gene,” it can yield results similar to caloric restriction – what is, at this time, the most tried and true method of extending the lifespans of a variety of model organisms.

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BRAIN TIME ► https://goo.gl/tTWgH2

A series of clinical trials have tested an experimental treatment for Parkinson’s disease that uses a novel approach: administering the drug straight into the brain via implanted ports. The leading researchers believe this may be a “breakthrough” therapeutic strategy for neurological conditions.

Newly trialed therapy could launch a fresh chapter in the treatment of Parkinson’s disease.

In a new series of studies that culminated with an open-label trial (where participants were aware of what treatment they would receive), scientists have begun testing the effectiveness of a new treatment — and method of delivery — for Parkinson’s disease.

“The future belongs to those who prepare for it today.”–Malcolm X “Be open-minded, but not so open-minded that your brains fall out.”–Groucho Marx In our …

It’s good to see a growing response to the materialist superstition about the mind and the brain from the neuroscience and philosophy community. Materialist theories of the mind are philosophically indefensible and scientifically discredited. Dualism is necessary to account for the immaterial nature of the intellect, for the metaphysical simplicity of the mind, and for free will. Of the varieties of dualism, I believe that Thomistic dualism offers the most satisfactory framework for neuroscience.

Continue reading “An Oxford Neuroscientist Explains Mind vs. Brain” »

Gut microbiome affect metabolic and neural diseases through alterations in epigenetic expressions by DNA methylation and miRNA modulations.

Unlike Neuralink, Synchron’s stent-like neural implant is a brain-computer interface that’s inserted through the jugular vein.

For the “big data” revolution to continue, we need to radically rethink our hard drives. Thanks to evolution, we already have a clue.

Our bodies are jam-packed with data, tightly compacted inside microscopic structures within every cell. Take DNA: with just four letters we’re able to generate every single molecular process that keeps us running. That sort of combinatorial complexity is still unheard of in silicon-based data storage in computer chips.

Add this to the fact that DNA can be dehydrated and kept intact for eons—500,000 years and counting—and it’s no surprise that scientists have been exploiting its properties to encode information. To famed synthetic biologist Dr. George Church, looking to biology is a no-brainer: even the simple bacteria E. Coli has a data storage density of 10¹⁹ bits per cubic centimeter. Translation? Just a single cube of DNA measuring one meter each side can meet all of the world’s current data storage needs.