Toggle light / dark theme

Among the biggest environmental problems of our time, micro-and nanoplastic particles (MNPs) can enter the body in various ways, including through food. And now for the first time, research conducted at MedUni Vienna has shown how these minute particles manage to breach the blood-brain barrier and as a consequence penetrate the brain. The newly discovered mechanism provides the basis for further research to protect humans and the environment.

Published in the journal Nanomaterials, the study was carried out in an with oral administration of MNPs, in this case polystyrene, a widely-used plastic which is also found in . Led by Lukas Kenner (Department of Pathology at MedUni Vienna and Department of Laboratory Animal Pathology at Vetmeduni) and Oldamur Hollóczki (Department of Physical Chemistry, University of Debrecen, Hungary) the research team was able to determine that tiny polystyrene particles could be detected in the brain just two hours after ingestion.

The mechanism that enabled them to breach the was previously unknown to medical science. “With the help of computer models, we discovered that a certain (biomolecular corona) was crucial in enabling plastic particles to pass into the brain,” Oldamur Hollóczki explained.

A stroke occurs when an artery in the brain becomes blocked or bursts. The brain cells beyond the blockage or bleed are deprived of oxygen and nutrients, so are damaged or die.

Scientists have been trying to find ways to minimize the damage following a stroke and speed up recovery.

Now, a study led by scientists from Weill Cornell Medicine has found changes in gene activity in small blood vessels following a stroke. The findings suggest that these changes could be targeted with existing or future drugs to mitigate brain injury or improve stroke recovery.

Organoids aren’t nearly as complex as their full-sized counterparts, but they’re useful for research — scientists can study organ development, monitor disease progression, and even test new treatments on them.

What’s new: When human embryos are about five weeks old, they develop structures called “optic cups” that will eventually become retinas.

Researchers have grown optic cups in the lab before, and they’ve also grown mini brains. Now, researchers at University Hospital Düsseldorf have grown brain organoids with optic cups.

In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution.

Thank you to our sponsors.
AG1 (Athletic Greens): https://athleticgreens.com/huberman.
ROKA: https://roka.com/huberman.
HVMN: https://hvmn.com/huberman.
Eight Sleep: https://eightsleep.com/huberman.
InsideTracker: https://www.insidetracker.com/huberman.

Supplements from Momentous.
https://www.livemomentous.com/huberman.

Huberman Lab Social & Website.
Instagram: https://www.instagram.com/hubermanlab.
Twitter: https://twitter.com/hubermanlab.
Facebook: https://www.facebook.com/hubermanlab.
TikTok: https://www.tiktok.com/@hubermanlab.
LinkedIn: https://www.linkedin.com/in/andrew-huberman.
Website: https://hubermanlab.com.
Newsletter: https://hubermanlab.com/neural-network.

Dr. Rechavi.
Academic Profile: https://en-lifesci.tau.ac.il/profile/odedrech_66
Lab Website: https://www.odedrechavilab.com.
Twitter: https://twitter.com/OdedRechavi.
TEDx Talk: https://www.ted.com/talks/oded_rechavi_transgenerational_biology?language=en.

Articles.

Summary: Brain areas that control movement are plugged into networks that orchestrate thinking and planning, and control involuntary bodily functions. The findings provide a link between the body and the “mind” in the brain’s structure.

Source: WUSTL

Calm body, calm mind, say the practitioners of mindfulness. A new study by researchers at Washington University School of Medicine in St. Louis indicates that the idea that the body and mind are inextricably intertwined is more than just an abstraction.

Findings point to brain areas that integrate planning, purpose, physiology, behavior, and movement.

Calm body, calm mind, say the practitioners of mindfulness. A new study by researchers at Washington University School of Medicine in St. Louis indicates that the idea that the body and mind are inextricably intertwined is more than just an abstraction. The study shows that parts of the brain area that control movement are plugged into networks involved in thinking and planning, and in control of involuntary bodily functions such as blood pressure and heartbeat. The findings represent a literal linkage of body and mind in the very structure of the brain.

The research, published on April 19 in the journal Nature, could help explain some baffling phenomena, such as why anxiety makes some people want to pace back and forth; why stimulating the vagus nerve, which regulates internal organ functions such as digestion and heart rate, may alleviate depression; and why people who exercise regularly report a more positive outlook on life.