Alzheimer’s disease is driven by a buildup of a toxic protein called Tau that kills neurons. As toxic Tau spreads to new regions of the brain, symptoms worsen and ultimately become fatal.
Now, researchers have discovered that, in mice, a brain protein called Arc helps spread Tau from sick brain cells to healthy ones.
If therapies could be designed to target the spread, they could be a powerful tool to stop Alzheimer’s disease from getting worse.
How does a single cell build a brain with billions of precisely organized neurons? Researchers suggest that brain cells use their lineage—their cellular family tree—as a kind of positional map. Cells that come from the same ancestor stay near one another, helping the brain organize itself without relying solely on chemical signals.
Physicist Carlo Rovelli recently proclaimed that consciousness is just another physical thing, while materialist philosophers argue that consciousness is simply one brain state observing another. What such views miss, argues Manfred Frank, a leading figure in contemporary German philosophy, is that consciousness comes with a built-in awareness of itself—an awareness that exists prior to any introspection or observation. Consciousness does not observe itself in the way we observe objects; rather, it dissolves the distinction between observer and observed altogether. This is why consciousness cannot be simply another object in the world, but instead exists in an entirely different dimension.
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If we had no consciousness our lives would be devoid of meaning. We have been immersed in this medium since before we were born and remain in it even in our dreams. And we do so without any effort on our part. Apart from when it is interrupted by deep sleep or we are unconscious after fainting or during anaesthesia, we remain in this state or are enveloped in it throughout our entire lives. Nothing is more familiar to us than consciousness; it is so familiar that we rarely notice it or attend to it.
Researchers identified a neural circuit connecting the brain’s reward and stress systems. In mice, chronic stress increased anxiety and activated stress-responsive neurons, while consuming palatable food reversed these effects.
Methods to acquire and process synaptic-resolution electron-microscopy datasets have progressed very rapidly, allowing production and annotation of larger, more complete connectomes. More accurate neuronal matching techniques are enriching cell type data with gene expression, neuron activity, behaviour and developmental information, providing ways to test hypotheses of circuit function. In a variety of behaviours such as learned and innate olfaction, navigation and sexual behaviour, connectomics has already revealed interconnected modules with a hierarchical structure, recurrence and integration of sensory streams.
A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.
Non-invasive brain stimulation (NIBS) shows considerable promise as a therapeutic strategy for neurological and psychiatric disorders. This Review explores the role of NIBS techniques, including repetitive transcranial magnetic stimulation and transcranial electrical stimulation, for treating cognitive impairments, speech and language difficulties, and motor control deficits in people with neurodegenerative or brain lesion disorders.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, impulsivity and/or hyperactivity. In recent years, metabolic alterations, primarily obesity, insulin resistance, and diabetes, have emerged as frequent comorbidities in individuals with ADHD, suggesting a bidirectional relationship between neurodevelopmental and metabolic dysfunctions. Emerging evidence indicates that dysregulation of dopaminergic signaling, disturbances in the hypothalamic-pituitary-adrenal (HPA) axis, and chronic low-grade inflammation are central to both ADHD symptomatology and metabolic impairments. For instance, alterations in dopamine-related genes (e.g., DRD4, DAT1) not only affect cognitive and behavioral functions but also play a role in appetite regulation and glucose homeostasis. Epidemiological studies further demonstrate that individuals with ADHD exhibit poorer glycemic control and a higher prevalence of both type 1 and type 2 diabetes, while early-life metabolic challenges such as maternal diabetes may predispose offspring to ADHD. This review aims to comprehensively synthesize the epidemiological, genetic, and pathogenetic evidence linking ADHD to metabolic alterations. We discuss key pathophysiological pathways—including dopaminergic dysregulation, HPA axis disturbances, inflammation, and oxidative stress—and evaluate their contributions to the co-occurrence of ADHD and metabolic disorders. In addition, we explore the clinical implications and integrated treatment approaches that encompass lifestyle modifications, pharmacological therapies, and multidisciplinary care. Finally, we outline future research directions to develop personalized and holistic interventions.
Is this the most controversial biotech advancement yet? 🧠 Inside this sneak peek of Mattcast #567, we break down a groundbreaking medical tech company testing on bodiless heads for neurological research.
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What if aging isn’t just biology…but also psychology — and your brain is quietly shaping how fast you age every day?
Dr. Srini Pillay, MD (https://drsrinipillay.com/) is a Harvard-trained psychiatrist, brain researcher, entrepreneur, author, and expert in the science of human potential, resilience, and longevity.
Dr. Pillay previously served as Assistant Professor of Psychiatry at Harvard Medical School and directed both the Outpatient Anxiety Disorders Program and the Panic Disorders Research Program in Brain Imaging at McLean Hospital, one of the world’s leading psychiatric institutions.
Over the course of his career, Dr. Pillay has focused on understanding how the brain shapes performance, creativity, emotional health, leadership, and even biological aging. His work bridges neuroscience, psychiatry, technology, and human behavior — translating cutting-edge brain science into practical tools for individuals, organizations, and healthcare systems.
Dr. Pillay is the co-founder and Chief Medical Officer of Reulay (https://www.reulay.com/), an AI-driven digital therapeutics and mindset technology company focused on healthy longevity, stress reduction, and human performance. He is also founder of the NeuroBusiness Group (https://nbgcorporate.com/), where he works with leaders and organizations around the world on brain-based approaches to innovation, adaptability, resilience, and navigating complexity in the age of AI.
Dr. Pillay is the author of several influential books including Tinker Dabble Doodle Try (https://www.amazon.com/Tinker-Dabble-?tag=lifeboatfound-20… which explores the neuroscience of creativity and the untapped power of the brain’s unconscious processing systems.