Lifeboat Foundation

Is a Gerontologist and Clinical Social Worker on a mission to rethink aging, longevity & mental health.

Ms. Anderson was also the former lead singer of the American Rock group, The Donnas (https://en.wikipedia.org/wiki/The_Donnas), where she was the lead vocalist for 20 years, performing throughout the U.S., as well as internationally, and had performances / appearances on major network shows including Saturday Night Live, David Letterman and Late Night with Conan O’Brien.

Continue reading “Brett Anderson, MSG, MSW — Journey From Rock Musician To Rethinking Aging, Longevity & Mental Health” »

A molecule found in green tea helped UCLA biochemists in the discovery of multiple molecules capable of destroying tau fibers.

University of California, Los Angeles (UCLA) researchers used a molecule present in green tea to uncover more molecules that may break up protein tangles in the brain, which are known to cause Alzheimer’s.

Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.

Summary: Of patients with dementia, 7% had chronic kidney disease while 9% had albuminuria, a urinary marker for kidney disease. Chronic kidney disease was associated with a 51% increased risk of developing dementia.

Source: American Society of Nephrology.

New research has demonstrated a link between kidney disease and the development of cognitive problems.

Read the accompanying news item: https://www.humanbrainproject.eu/en/follow-hbp/news/ebrains-…disorders/

Using the EBRAINS research infrastructure, scientists of the Human Brain Project have developed multi-scale simulations of the human brain that mimic hallmarks of activity during wake and deep sleep states. Such simulations can lead to a better understanding of biological mechanisms that regulate human consciousness and its disorders, which span from single neurons to whole brain scales.

Large Language Models have the ability to store vast amounts of facts about the world. But little is known, how these models actually do this. This paper aims at discovering the mechanism and location of storage and recall of factual associations in GPT models, and then proposes a mechanism for the targeted editing of such facts, in form of a simple rank-one update to a single MLP layer. This has wide implications both for how we understand such models’ inner workings, and for our ability to gain greater control over such models in the future.

OUTLINE:
0:00 — Introduction.
1:40 — What are the main questions in this subfield?
6:55 — How causal tracing reveals where facts are stored.
18:40 — Clever experiments show the importance of MLPs.
24:30 — How do MLPs store information?
29:10 — How to edit language model knowledge with precision?
36:45 — What does it mean to know something?
39:00 — Experimental Evaluation & the CounterFact benchmark.
45:40 — How to obtain the required latent representations?
51:15 — Where is the best location in the model to perform edits?
58:00 — What do these models understand about language?
1:02:00 — Questions for the community.

Continue reading “ROME: Locating and Editing Factual Associations in GPT (Paper Explained & Author Interview)” »

Summary of the study.

A major hallmark of Parkinson’s disease is the loss of dopamine-producing neurons in the brain, which in turn causes patients to lose motor control abilities. NYSCF – Robertson Stem Cell Investigator Alumna Malin Parmar, PhD, of Lund University, has spent a decade developing a cell therapy to replace these cells, and this revolutionary treatment (called ‘STEM-PD’) has just received approval for a Phase I/IIa clinical trial in Sweden.

“We are excited and looking forward to this clinical study of STEM-PD, hoping that it could potentially help reduce the significant burden of Parkinson’s disease. This has been a massive team effort for over a decade, and the regulatory approval is a major and important milestone,” said Dr. Parmar, who is a Professor of Developmental and Regenerative Neurobiology at Lund, in a statement.

Dr. Parmar’s innovative work towards a Parkinson’s cell therapy earned her the NYSCF – Robertson Stem Cell Investigator Award in 2016, which provided support for her lab’s research until 2021, including her work on STEM-PD.

This is my rebuttal to the recent MIT Technology Review article by Michael Hendricks. The views expressed here are mine alone and should not be taken as an official statement from the BPF which is an organization with a diverse range of opinions but a common goal to advocate more scientific research into brain preservation…

Regenerative medicine company Frequency Therapeutics is developing new drugs that activate our innate abilities to restore function and reverse degenerative diseases. The company is working on small molecules that selectively activate progenitor cells already present within our bodies to create healthy, functional tissues. Frequency’s initial focus is on hearing loss and multiple sclerosis, and the company has just completed enrolment of a Phase 2b trial in adults with acquired sensorineural hearing loss (SNHL).

Longevity. Technology: Frequency is focused on progenitor cells, which are like stem cells but can only make cells that belong to the same tissue or organ. While progenitor cells remain active in some of our organs and tissues, they can become dormant in others. Frequency’s small molecules are designed to selectively target and induce dormant progenitor cells to create specific cell types to restore tissue structure and function. We caught up with Frequency’s Chief Scientific Officer Dr Chris Loose to learn more.

Nasdaq-listed Frequency was founded in 2014, licensing technology developed by professors Robert Langer from MIT and Jeffrey Karp from Harvard Medical School.