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Single Nucleotide SMN1 Variants in a Cohort of Individuals With Spinal Muscular Atrophy

Background and ObjectivesSpinal muscular atrophy 5q (SMA) is a motor neuron disorder caused by recessive pathogenic variants in the SMN1 gene, which encodes the survival motor neuron (SMN) protein. While the majority of patients with SMA exhibit…

Impaired touch perception in Alzheimer’s associated with Tau pathology and lower cognitive scores

Alzheimer’s disease (AD) is a neurodegenerative condition characterized by the progressive deterioration of brain cells, which prompts memory loss, a decline in mental functions and behavioral changes. Estimates suggest that this disease affects approximately 1 in 14 people who are more than 65 years old and over 35% of people who are over 85 years old.

Due to its prevalence and debilitating nature, AD has become the focus of numerous neuroscience and medical studies. Most of these studies examined brain regions and neurogenetic processes that appear to be different in people diagnosed with AD.

Recently, some neuroscientists gathered evidence suggesting that parts of the brain that support somatosensory processing (i.e., the interpretation of tactile stimuli, pressure and the body’s position in space), are also affected in individuals with AD. Yet the extent to which these tactile sensation-related deficits play a role in the cognitive decline typical of AD has not yet been determined.

Does the Brain Become Dull With Age? New Study Shows How the Brain Gradually Changes | GRAVITAS

Discover the four major turning points that reshape your brain. From childhood sharpening to late-life resilience, watch how your brain rewires itself through life. Learn the science behind cognitive peaks, aging, and brain health, and uncover the hidden timeline of your mind’s transformation. Don’t miss this deep dive into how the brain evolves over a lifetime.

#childhood #brain #science #wion.

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How Gen Z is fighting back against digital brain rot

“Brain rot is not really rotting our brains,” says Earl Miller, a cognitive neuroscientist at Massachusetts Institute of Technology. “It’s constantly creating an environment that our brains are not equipped to deal with—that’s the real problem.


From analog hobbies to tech curfews, these Gen Zers are experimenting with science-backed ways to help their brains feel a little less foggy.

Environmental stiffness regulates neuronal maturation

When thinking, the human brain performs a true masterpiece of information processing: around 100 billion neurons communicate with each other via approximately 100 trillion connections. An international team of researchers has discovered that the mechanical properties of the developing brain influence both synapse formation and the emergence of electrical signals. The findings could open up new approaches to understanding neurodevelopmental disorders.

In the brain, highly specific connections called synapses link nerve cells and transmit electrical signals in a targeted manner. Despite decades of research, how synapses form during brain development is still not fully understood. Now, an international research team has discovered that the mechanical properties of the brain play a significant role in this developmental process. In a study recently published in Nature Communications, the scientists showed how the ability of neurons to detect stiffness is related to molecular mechanisms that regulate neuronal development.

The developing brain is generally very soft, like cream cheese, but its stiffness varies across regions. In African clawed frog (Xenopus laevis) embryos, the researchers found that softer regions exhibit higher synapse densities, while stiffer regions show lower densities.

Scientists Discover a Way to ‘Recharge’ Aging Human Cells

New research shows how human cells can be effectively ‘recharged’ by replacing their internal batteries – microscopic power stations called mitochondria – and the discovery could have wide-ranging benefits across healthcare and medical treatments.

The stacks of mitochondria in most of our cells naturally decline in numbers, slow down, and wear out with age. Once they start operating below peak capacity, they can contribute to multiple diseases everywhere from the heart to the brain.

In this latest study, researchers from Texas A&M University used special flower-shaped particles called nanoflowers to scavenge damaging oxygen molecules, triggering genes that increase the number of mitochondria in human stem cells.

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