Scientists have created a breakthrough technology that reveals the entire network of RNA-protein interactions in human cells, offering new insights into how diseases develop.
Category: neuroscience – Page 29
Experiment explores contribution of neural, epigenetic and behavioral factors to autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is estimated to be experienced by roughly 1 in 127 people worldwide. It is characterized by atypical patterns in brain development, which manifest in differences in communication, social interactions, behavior and responses to sensory information.
Past neuroscientific and genetic studies suggest that a variety of factors contribute to the development of ASD. These can include genetic factors, chemical alterations that influence the expressions of genes (i.e., epigenetic factors), differences in the structure of specific brain regions or neural circuits, and environmental factors, such as early life events or infections or immune responses during pregnancy.
Researchers at the Korea Brain Research Institute and University of Fukui in Japan recently carried out a study aimed at further exploring these different dimensions of ASD, focusing on brain structure, the communication between brain regions, epigenetic changes and behavioral patterns. Their findings, published in Translational Psychiatry, paint a clearer picture of the intricate underpinnings of the disorder and could inform the development of more precise tools for diagnosing it.
Brain shape changes could offer early warning signs of dementia
A new study led by University of California, Irvine’s Center for the Neurobiology of Learning and Memory researchers found that aging changes the brain’s overall shape in measurable ways. Instead of focusing only on the size of specific regions, the team used a new analytic method to see how the brain’s form shifts and distorts over time.
The analysis revealed substantial alterations in brain shape, which were closely associated with declines in memory, reasoning and other cognitive functions. This suggests that the shape of the brain can serve as a reliable indicator of its overall health. The study appears in Nature Communications.
“Most studies of brain aging focus on how much tissue is lost in different regions,” said Niels Janssen, Ph.D., senior author and professor at Universidad de La Laguna in Spain and visiting faculty at the CNLM. “What we found is that the overall shape of the brain shifts in systematic ways, and those shifts are closely tied to whether someone shows cognitive impairment.”
Autism should not be seen as single condition with one cause, say scientists
Autism should not be viewed as a single condition with a unified underlying cause, according to scientists who found that those diagnosed early in childhood typically have a distinct genetic profile to those diagnosed later.
The international study, based on genetic data from more than 45,000 autistic people in Europe and the US, showed that those diagnosed in early childhood, typically before six years old, were more likely to show behavioural difficulties from early childhood, including problems with social interaction, but remain stable.
Those diagnosed with autism later, typically after the age of 10, were more likely to experience increasing social and behavioural difficulties during adolescence and also had an increased likelihood of mental health conditions such as depression.
Study reveals genetic and developmental differences in people with earlier versus later autism diagnosis
Researchers find different genetic profiles related to two trajectories that autistic children tend to follow. One is linked to early diagnosis and communication difficulties in infancy. The other is linked to later diagnosis, increased social and behavioral difficulties in adolescence, and higher rates of conditions like ADHD, depression, and PTSD.
An international study led by researchers at the University of Cambridge has discovered that autism diagnosed in early childhood has a different genetic and developmental profile than that of autism diagnosed from late childhood onwards.
The scientists say that the findings challenge the long-held assumption that autism is a single condition with a unified underlying cause.
Materialism and Consciousness: The Case of Philosophical Zombies David Chalmers
This is one of the Royal Institute of Philosophy’s 15-minute Philosophy Briefings, a series in which eminent philosophers provide their own view of a key philosophical topic, in straightforward and accessible language.
Each one is designed to be a resource for anyone who wants to know more about these questions, whether you are covering them at A-level, teaching them at A-level, studying Philosophy at university, or are simply curious to know more.
David Chalmers, Professor of Philosophy and Neural Science at New York University and co-director of NYU’s Center for Mind, Brain, and Consciousness, looks at whether there exist philosophical zombies.
PA-915 molecule shows long-lasting antidepressant effects without common side effects in mice
Depression and anxiety disorders are among the most widespread mental health disorders, with estimates suggesting that they affect around 264 million and 284 million people worldwide, respectively. Depression is a mood disorder characterized by persistent sadness and a loss of interest in everyday activities, while anxiety disorders are marked by high levels of nervousness, worry and fear, either in specific situations or generalized.
Today, there are several treatment options for both depression and anxiety disorders, including both pharmacological drugs and specific types of psychotherapy. Yet available therapeutic strategies are not effective for all affected individuals; thus, identifying alternative treatments could be highly advantageous.
Researchers at the University of Osaka, Kobe University School of Medicine, Hamamatsu University School of Medicine and other institutes have recently developed a new molecule called PA-915, which could hold some promise for the treatment of depression, anxiety and stress-related disorders. In a paper published in Molecular Psychiatry, they showed that the molecule suppressed both anxiety-like and depression-like behaviors in mice who were placed under high levels of stress.
How gene mutations drive dementia in Parkinson’s disease
Parkinson’s disease causes both movement and cognitive deficits, and for a long time both were thought to be caused by the accumulation of a protein called alpha-synuclein in the brain. But a new Nature Communications study has found that the cognitive deficits arise through a different—and unexpected—mechanism.
The new findings suggest that mutations in a gene called GBA—which are a risk factor for developing Parkinson’s disease—drive cognitive decline by disrupting how neurons communicate with each other in the brain. Patients living with Parkinson’s disease can experience cognitive symptoms such as difficulty with concentrating and forgetfulness. Over time, many go on to develop dementia, in which they experience profound memory loss among other symptoms.
“Dementia is often the scariest thing for many patients with Parkinson’s disease, more so than motor symptoms,” says Sreeganga Chandra, PhD, professor of neurology and of neuroscience at Yale School of Medicine (YSM) and the study’s principal investigator. “We are trying to understand the basis of cognitive dysfunction and whether we can find targets to ameliorate it.”