Lifeboat Foundation

For the first time, scientists will be able to test therapeutics for a group of rare neurodegenerative diseases that affect infants and young children, thanks to a new research model created by scientists at the University of Wisconsin-Madison. Their results are published in the Proceedings of the National Academy of Sciences.

Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative diseases caused by genetic mutations. They lead tens of thousands of children to develop increased muscle tone in their lower extremities, causing weakness in their legs and ultimately affecting their ability to crawl or walk.

“Kids as early as six months of age that have these mutations start to show signs of disease,” says Anjon Audhya, a professor in the Department of Biomolecular Chemistry at UW-Madison. “Between two and five years of age, these kids become wheelchair-bound, and they unfortunately will never be able to walk.”

Associate Professor Miriam Klein-Flügge and colleagues looked at brain connectivity and mental health data from nearly 500 people. In particular, they looked at the connectivity of the amygdala – a brain region well known for its importance in emotion and reward processing. The researchers used functional magnetic resonance imaging to consider seven small subdivisions of the amygdala and their associated networks rather than combining the whole region together as previous studies have done.

The team also adopted a more precise approach to the data on mental wellbeing, looking at a large group of healthy people and using questionnaires that captured information about wellbeing in the social, emotional, sleep, and anger domains. This generated more precise data than many investigations which still use broad diagnoses such as depression or anxiety, which involve many different symptoms.

The paper, published in Nature Human Behaviour, shows how the improved level of detail about both brain connectivity and wellbeing made it possible to characterise the exact brain networks that relate to these distinct aspects of mental health. The brain connections that mattered most for discerning whether an individual was struggling with sleep problems, for example, looked very different from those that carried information about their social wellbeing.

Brain-computer interfaces may have a profound effect on people with limited mobility or other disabilities, but experts say they also introduce privacy issues that must be mitigated.

Science may be getting closer to figuring out where consciousness resides in the brain. New research demonstrates the significance of certain kinds of neural connections in identifying consciousness.

Jun Kitazono, a corresponding author of the study and project researcher at the Department of General Systems Studies at the University of Tokyo, conducted the study, which was published in the journal Cerebral Cortex.

“Where in the brain consciousness resides has been one of the biggest questions in science,” said Associate Professor Masafumi Oizumi, corresponding author and head of the lab conducting the study. “Although we have not reached a conclusive answer, much empirical evidence has been accumulated in the course of searching for the minimal mechanisms sufficient for conscious experience, or the neural correlates of consciousness.”

Summary: Study reveals altered brain dynamics in those with unresponsive arousal syndrome, previously known as “vegetative state”, and in those with minimally conscious state.

Source: University of Liege.

A study by the Human Brain Project (HBP), led by scientists from the University of Liège (Belgium), has explored new techniques that may help distinguish between two different neurological conditions in patients with severe brain damage and or in a coma. The results of this study have just been published in open access in the journal eLife.

Summary: Researchers aim to map and track cellular changes in the human brain over a lifetime.

Source: UCSD

With a five-year, $126 million grant from the National Institutes of Health (NIH), a multi-institution team of researchers at University of California San Diego School of Medicine, Salk Institute for Biological Studies and elsewhere has launched a new Center for Multiomic Human Brain Cell Atlas.

Welcome to another episode of Conversations with Coleman.

My guest today is David Chalmers. David is a professor of philosophy and neuroscience at NYU and the co-director of NYU Centre for Mind, Brain and Consciousness.

Continue reading “Are We Living in a Simulation with David Chalmers [S3 Ep.12]” »

Since the beginning of human storytelling, enhancing oneself to a “better version” was of vital interest to humans. A twenty-first century-philosophical movement called transhumanism dedicated itself to the topic of enhancement. It unites discussions from several disciplines, e.g. philosophy, social science, and neuroscience, and aims to form human beings in desirable ways with the help of science and technology (Bostrom, 2005; Loh, 2018; More, 2013). Enhancement is the employment of methods to enhance human cognition in healthy individuals (Colzato et al., 2021), thereby extending individual performance above already existing abilities. It should thus be distinguished from therapy, which is the application of methods to help individuals with illnesses or dysfunctions in restoring their abilities (Viertbauer & Kögerler, 2019). Although enhancement methods bear psychological implications, there is hardly any psychological research on them. However, as the use of enhancement methods has increased (Leon et al., 2019; McCabe et al., 2014), and with it the demand for official guidelines (Jwa, 2019), it is necessary to examine who would use these methods in the first place, especially because these technologies can easily be misused. Investigating personality traits and values of individuals who want to enhance themselves could not only support suppliers and manufacturers of enhancement technologies in creating guidelines for using enhancement, but also raise more general awareness on which individuals might be in favour of enhancement.

In previous studies investigating the intersection between enhancement and personality traits or values, vignettes were used to describe enhancement methods and to measure their acceptance among participants (e.g. Laakasuo et al., 2018, 2021). Thus, subjects were asked to read scenarios involving the use of a certain enhancement method and then—as a measure of acceptance—judge aspects (e.g. the morality) of the action undertaken in the corresponding scenario (e.g. Laakasuo et al., 2018, 2021). In the present study, we followed a similar vignette-based approach with a variety of different enhancement methods to investigate the link between the acceptance of enhancement (i.e., the willingness to use enhancement methods, hereinafter termed AoE), personality traits, and values. More specifically, we examined the acceptance of the most discussed cognitive enhancement methods: pharmacological enhancement, brain stimulation with transcranial electrical stimulation and deep brain stimulation, genetic enhancement, and mind upload (Bostrom, 2003; Dijkstra & Schuijff, 2016; Dresler et al., 2019; Gaspar et al., 2019; Loh, 2018).

Pharmacological enhancement has received much attention in the media and literature (Daubner et al., 2021; Schelle et al., 2014) and is defined as the application of prescription substances that are intended to ameliorate specific cognitive functions beyond medical indications (Schermer et al., 2009). The best-known drugs for cognitive enhancement are methylphenidate (Ritalin®), dextroamphetamine (Adderall®), and modafinil (Provigil®), which are usually prescribed for the treatment of clinical conditions (de Jongh et al., 2008; Mohamed, 2014; Schermer et al., 2009).

Booting biology systems readouts.
Bio-monitors on.
Choice.
Graph five… engage.
Change brain wave parameters.
Brain wave pattern altered.
Prepare brain stem injection.
Initiate brain stem.
Insertion complete.
Synaptic reaction positive.
Change brain wave parameters.
Initiate second level.
Insertion complete.
Initiate brain stem.
Brain wave pattern altered.
Warning.
Shut down theta stimulation.
Warning.
Endocrine, adrenal, increasing to fatal levels.
System shutdown.