Liu et al. present a remarkably simple yet clever method of mitigating the effects of head-mounted microscopes on mouse behavior: they tethered a helium balloon to the microscope device to counter its weight! A fun and useful engineering solution!
Link to article.
Scientific Reports — Alleviating head-mounted weight burden for neural imaging in freely-behaving rodents. Sci Rep 15, 19175 (2025). https://doi.org/10.1038/s41598-025-04300-0
When cells are healthy, we don’t expect them to suddenly change cell types. A skin cell on your hand won’t naturally morph into a brain cell, and vice versa. That’s thanks to epigenetic memory, which enables the expression of various genes to “lock in” throughout a cell’s lifetime. Failure of this memory can lead to diseases, such as cancer.
Traditionally, scientists have thought that epigenetic memory locks genes either “on” or “off” — either fully activated or fully repressed, like a permanent Lite-Brite pattern. But MIT engineers have found that the picture has many more shades.
In a new study appearing today in Cell Genomics, the team reports that a cell’s memory is set not by on/off switching but through a more graded, dimmer-like dial of gene expression.
Spaceflight makes certain human stem cells age faster, a new study has found, furthering scientists’ understanding of the potential effects of space exploration on the human body.
Stem cells are found throughout the body, and they can make more of themselves or turn into other specialized cells — including blood, brain or bone cells — for maintenance and repair.
“In space, stem cells decline in function,” said lead study author Catriona Jamieson, director of the Sanford Stem Cell Institute and professor of medicine at the University of California, San Diego School of Medicine. “They actually reduce their ability to renew themselves or regenerate, and that’s an important thing to be able to know for long-term space missions.”
A new study from Aarhus University shows that our cells’ ability to clean out old protein clumps, known as aggregates, also includes a—up till now unknown—partnership with an engine that breaks down bigger pieces into smaller before “taking it to the trash.” An important find for future treatments of diseases like Alzheimer’s, Parkinson’s, ALS and Huntington’s, which are all characterized by the accumulation of protein in the brain.
Imagine you’re about to eat a big pizza. In order to not choke on it, you cut it up into slices and eat it bite by bite. And while you’re chomping down on your slices, cells inside your body are busy slicing the built-up protein clumps into pieces that are more manageable for the body’s trash system—otherwise it would clog up and malfunction.
Researchers from the department of Biomedicine at Aarhus University have just released a new study, which for the first time documents exactly how those clumps of unwanted protein get reduced to smaller pieces before being disposed of by the cells’ garbage disposal system—called autophagy. The work is published in the journal Nature Cell Biology.
To shed new light on the contribution of different brain regions and neural circuits to specific mental functions, neuroscientists and medical researchers rely on advanced imaging techniques and neural probes. These are electronic devices embedding electrodes, components that can measure the electrical impulses produced by neurons, which are known as spikes.
While existing probes have helped to map various networks of neurons and understand their functions, most of them have two-dimensional (2D) layouts. This is because they are made employing conventional semiconductor-based devices and fabrication strategies.
Researchers at Dartmouth College, University of Pittsburgh, Oklahoma State University and other institutes have developed a new approach that could enable the fabrication of soft three-dimensional (3D) neural probes on a large scale. Their proposed method, outlined in a paper published in Nature Electronics, entails the rolling of flat electronic devices into cylindrical 3D structures.
For those partnered up in a long-term relationship, studies have shown that different health characteristics can sometimes be shared across the couple – and that extends to psychiatric disorders, according to new research.
Based on an analysis of more than 6 million couples across Taiwan, Denmark, and Sweden, an international team of researchers found that people were significantly more likely to have the same psychiatric conditions as their partners than would be expected by chance.
Those conditions included schizophrenia, attention deficit hyperactivity disorder (ADHD), depression, autism, anxiety, bipolar disorder, obsessive-compulsive disorder (OCD), substance abuse, and anorexia nervosa.