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Category: neuroscience – Page 1,094

An article written by Dr Michael Fossel talking about telomerase therapy for Alzheimer’s and the work Bioviva and Telocyte are doing to beat this horrific condition.

Reversing Alzheimer’s by Lengthening Telomeres.

There are telomere lengthening compounds available right now for use in research labs. They are not currently available for human use. A group of scientists wants to test these compounds on aging humans now to see if the telomere lengthening effects will induce meaningful age reversal effects.

Telomeres in our cells shorten as we grow older and create cellular havoc that predisposes us to multiple age-related pathologies. These experimental enzymes promote telomere lengthening and in the process offer an intriguing opportunity to circumvent biological aging processes.

Alzheimer’s disease has no cure and evidence points at microglial epigenetic changes being the cause of the inability to remove misfolded proteins in neurons. This proposed study will evaluate the effect the use of hTERT (human telomerase reverse transcriptase) to reverse biomarkers and symptomatology of aging with special target of the microglia cells in Alzheimer’s patients. Misfolded beta amyloids can be effectively cleared by healthy microglia. This could represent a clinical breakthrough in Alzheimer’s treatment that would be immediately available in the clinical setting.

How Alzheimer’s Can Be Prevented and Cured…

Michael Fossel, MD, PhD

As I said in my medical textbook on aging, “If age is a thief, then the greatest treasure we lose is ourselves.”

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[From CNN]

Human ‘mini brains’ grown in labs may help solve cancer, autism, Alzheimer’s

mini_brain

Story highlights

  • Ohio State biomedical research team grows nearly complete human ‘mini brain’
  • Brain organoids can be used to learn more about diseases like cancer, Alzheimer’s and Parkinson’s
  • Brain organoids could yield autism breakthrough within 10 years, researcher says

By Thom Patterson | Video Source: CNN
Read the full story CNN…

Ray Kurzweil’s singularity of human superintelligence is a polar opposite of the singularity described by Vinge, Hawking, and Bostrom:

“The singularity will be a merger of our bodies and minds with our technology. The world will still be human, but transcend our biological roots. There will be no distinction between human and machine, nor between physical and virtual reality.”

Dear readers,

This month celebrates the 10 year anniversary of the classic book The Singularity Is Near, written by Ray Kurzweil, published in September 2005.

In the decade since its publication, we’ve witnessed an explosion of breakthroughs in genetic engineering, medical regeneration of the human body, autonomous robotics, computing power, and renewable energy. Advanced sensor arrays and internet meshes are uniting all people and things within the interconnected environments we live in, and with each other. Today’s massively scaled, crowd-sourced knowledge, innovation, and shared human experience are driving this momentum. The future is now.

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Memory loss is a truly devastating part of dementia, but this invention aims to fix that by bypassing the damage, and repairing long term memory.

Alzheimer’s and dementia are complex diseases, and there’s currently no effective treatment. Given the unpleasant nature of the disease, there’s an urgent need for results. Instead of taking the usual biological route, one team has constructed a prosthetic made up of a small electrode array — which can help re-encode short term memory into long term.

Built using decades of research, the device operates using a new algorithm based on accumulated neural data. New sensory information is normally translated into a quick memory and transported as an electrical signal through the hippocampus, potentially for long term storage. If this region is damaged then the process is disturbed, and new experiences fail to be encoded. Alzheimer’s patients can often remember childhood events, but struggle with recent experiences; specifically because of this hippocampal damage.

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Could discovering how neural stem cells protect themselves from damage lead to treatment that helps combat aging?

We now know that stem cells in the brain do in fact divide, and that this regenerative capacity begins to falter with age. The majority of our cells don’t divide, and the bulk of division falls to stem cell niches dotted across our body. Stem cell populations do age, but they’re more resistant than ‘normal’ cells are, and they produce higher levels of telomerase — enabling them to divide for years.

How do brain stem cells remain free of damage?

Neural stem cells aren’t perfectly protected from aging, but they’re generally a hardier bunch. Scientists from the University of Zurich have now discovered that part of this aging resistance in neural stem cells is due to a ‘diffusion barrier’. When they divide, these cells produce a barrier which filters out damaged proteins to one side, allowing the new cell to be damage-free.

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Brain speed declines for most people with age, and new data shows it may be because of increasingly busy, noisy circuits.

The human brain takes in a lot of information. Everyone has to deal with a slog of incoming data every day, and add it to an ever expanding bank of knowledge. Your brain re-organises itself pretty well, but new research suggests this clutter begins to have effects as it builds up.

A clouded brain.

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Scientists funded by the NIH BRAIN Initiative hope to diagram all of the circuits in the brain. One group will attempt to identify all of the connections among the retina’s ganglion cells (red), which transmit visual information from bipolar cells (green) and photoreceptors (purple) to the brain. (credit: Josh Morgan, Ph. D. and Rachel Wong, Ph. D./University of Washington)

The National Institutes of Health and the Kavli Foundation separately announced today (Oct. 1, 2015) commitments totaling $185 million in new funds supporting the BRAIN Initiative — research aimed at deepening our understanding of the brain and brain-related disorders, such as traumatic brain injuries (TBI), Alzheimer’s disease, and Parkinson’s disease.

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