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Category: neuroscience – Page 1,021

Very promising for Giloblastoma patients.

Adding Tumor Treating Fields (TTFields) to maintenance temozolomide significantly prolongs both median and long-term survival.

Among patients with newly diagnosed glioblastoma multiforme, adding Tumor Treating Fields (TTFields) to maintenance temozolomide significantly prolongs both median and long-term survival, according to a study presented 21st Annual Scientific Meeting of the Society of Neuro-Oncology (SNO).

TTFields is a frequency-tuned, anti-mitotic, physical treatment modality delivered to the brain through a patient-operated, portable medical device called Optune. Results of a pre-specific successful interim analysis of the international, phase 3 trial (ClinicalTrials.gov Identifier: NCT00916409) comparing TTFields and temozolomide with temozolomide alone after radiotherapy and adjuvant temozolomide led to the approval of TTFields for the treatment of adult patients with glioblastoma.

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Physical plasma is one of the four fundamental states of matter, together with solid, liquid, and gas, and can be completely or partially ionized (thermal/hot or non-thermal/cold plasma, respectively). Non-thermal plasma has many industrial applications, but plasma medicine is a new field of therapy based on non-thermal atmospheric pressure plasma that has been used in cancer treatment, wound healing, and blood coagulation. Plasma is known to react with air to produce highly reactive free radicals, and with liquid to produce long-lived reactive molecules that can be used for chemotherapy. However, the exact components responsible for the anti-tumor effects were unknown.

Now, a research team based at Nagoya University used plasma to activate Ringer’s solution, a salt solution with existing therapeutic functions, and showed that its lactate component had anti-tumor effects.

Previous work by the researchers developed plasma-activated cell culture medium as a form of chemotherapy, but selected Ringer’s solution in the present work because of its simpler composition and likelihood of forming less complex reaction products. Ringer’s lactate solution (Lactec) was irradiated with plasma for 3–5 minutes, after which it demonstrated anti-tumor effects on brain tumor cells.

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Westworld recently wrapped its first season with a few stunning twists and a stunning statistic: With a 12-million-viewer average, it was the most-watched first season of an original HBO show in the network’s history. Westworld concerns a perverse theme park, styled in the fashion of the American Old West. The park’s “hosts,” artificially intelligent beings physically indistinguishable from humans, begin to remember the horrifying experiences inflicted on them by the park’s “guests,” the humans who pay to visit and do as they please, including raping and killing hosts.

Robert Ford (Anthony Hopkins), the fictional cofounder of Westworld, built the park’s hosts with the ability to improvise and make decisions based on their environment—a vision of AI strikingly similar to the one held by Simon Stringer, the director of the Oxford Centre for Theoretical Neuroscience and Artificial Intelligence. Stringer is one of the field’s leading thinkers, and like Ford, he says machines with some internalized spatial and causal model of the world could achieve an intuitive, human-like intelligence.

In my conversation with Stringer about Westworld, we discussed what makes AI seem human, the potential threat AI poses to humans, the role of self-modifying programming, and the importance of the Turing Test.

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Researchers used X-ray videos (right) to capture and trace the movements of the different parts of a macaque’s vocal anatomy — such as the tongue, lips, and larynx — during a number of orofacial behaviors. (credit: Illustration by Tecumseh Fitch, University of Austria, and image courtesy of Asif Ghazanfar, Princeton Neuroscience Institute)

While they have a speech-ready vocal tract, primates can’t speak because they lack a speech-ready brain, contrary to widespread opinion that they are limited by anatomy, researchers at Princeton University and associates have reported Dec. 9 in the open-access journal Science Advances.

The researchers reached this conclusion by first recording X-ray videos showing the movements of the different parts of a macaque’s vocal anatomy — such as the tongue, lips and larynx. They then converted that data into a computer model that could predict and simulate a macaque’s vocal range.

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IBM Watson is known for its work in identifying cancer treatments and beating contestants on Jeopardy! But now the computing system has expertise in a new area of research: neuroscience.

Watson discovered five genes linked to ALS, sometimes called Lou Gehrig’s disease, IBM announced on Wednesday. The tech company worked with researchers at the Barrow Neurological Institute in Phoenix, Arizona. The discovery is Watson’s first in any type of neuroscience, and suggests that Watson could make discoveries in research of other neurological diseases.

SEE ALSO: This high-tech E.L.F. is guiding confused shoppers with the help of IBM’s Watson.

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Nice.

Chronic pain is thought to involve the long-lasting strengthening of synapses, akin to what happens during the formation of new memories. This phenomenon, known as long-term potentiation (LTP), is triggered when neurons on both sides of a synapse are active at the same time. But now, Jürgen Sandkühler, Medical University of Vienna, Austria, and colleagues provide evidence that LTP in nociceptive circuits arises in a different way.

By simultaneously activating two types of glial cells―astrocytes and microglia―the researchers were able to produce LTP at synapses that connect peripheral C-fibers and lamina I neurons in the dorsal horn spinal cord. They also showed that with high-frequency stimulation of C-fibers, glial cells strengthen active and inactive synapses through their release of the NMDA receptor co-agonist D-serine and the cytokine tumor necrosis factor (TNF). Moreover, these molecules traveled to distant synapses, perhaps explaining why pain hypersensitivity can develop in areas surrounding or far away from an injury.

“This paper is going to stimulate a lot of discussion that will lead to important advances for all of us in the pain field,” said Theodore Price, The University of Texas at Dallas, US, who was not involved in the study. “It raises questions for my lab in our day-to-day research that we can address immediately. That’s ultimately the true measure of a really good paper.”

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More proof that Precision Medicine can predict and solve complex health issues.

Brain scans could help predict response to psychotherapy for anxiety and depression.

brain-scan-treatment-research

Nov. 10, 2016 – Brain imaging scans may one day provide useful information on the response to psychotherapy in patients with depression or anxiety, according to a review of current research in the November/December issue of the Harvard Review of Psychiatry, published by Wolters Kluwer.

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Progress with Alzheimers and this time approaching it from the direction of Tau as a target rather than Beta Amyloid. This therapy has been tested in people and whilst it is only the first step hopefully this will lead to an effective treatment for this horrific diseases and and end to the suffering it brings.

Progress towards immunotherapies that can clear tau for Alzheimers here. Most therapies are focused on misfolded amyloid-β proteins but this particular approach targets Tau and the first in human test has proceeded!

“The authors of the study have developed a vaccine that stimulates the production of an antibody that specifically targets pathological tau, discovering its “Achilles’ heel”. It is able to do this because healthy tau undergoes a series of changes to its structure forming a new region that the antibody attacks. This new region (the “Achilles’ heel”), while not present in healthy tau, is present in diseased tau early on. Therefore, the antibody tackles all the different varieties of pathological tau. In addition to this important specificity, the antibody is coupled to a carrier molecule that generates a considerable immune response with the added benefit that it is not present in humans, thus avoiding the development of an immune reaction towards the body itself.”

#aging #crowdfundthecure

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Excellent overview on BMI technology.

Less than a century ago, Hans Berger, a German psychiatrist, was placing silver foil electrodes on his patients’ heads and observing small ripples of continuous electrical voltage emerging from these. These were the first human brain waves to ever be recorded. Since Hans Berger’s first recordings, our knowledge on the brain structure and function has developed considerably. We now have a much clearer understanding of the neuronal sources that generate these electrical signals and the technology that is now available allows us to get a much denser and accurate picture of how these electrical signals change in time and across the human scalp.

The recording and analysis of brain signals has advanced to a level where people are now able to control and interact with devices around them with the use of their brain signals. The field of brain-computer interfaces has in fact garnered huge interest during the past two decades, and the development of low-cost hardware solutions together with the continuously evolving signal analysis techniques, have brought this technology closer to market than ever before.

Research in the field of brain-computer interfaces was primarily propelled by the need of finding novel communication channels for individuals suffering from severe mobility disorders as in the case of patients with locked-in syndrome. People suffering from the condition have a perfectly functioning brain but are trapped inside their body, which no longer responds to the signals being transmitted from their brain.

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