In a recent study published in Neuron, researchers discovered that microglia, the brain’s immune cells, use tunneling nanotubes…
Scheiblich et al. uncover a novel mechanism by which microglia use tunneling nanotubes to connect with α-syn-or tau-burdened neurons, enabling transfer of these proteins to microglia for clearance. Microglia donate mitochondria to restore neuronal health, shedding light on new therapeutic strategies for neurodegenerative diseases.
Nano-MIND Technology for Wireless Control of Brain Circuits with Potential to Modulate Emotions, Social Behaviors, and Appetite.
Researchers at the Center for Nanomedicine within the Institute for Basic Science (IBS) and Yonsei University in South Korea have unveiled a groundbreaking technology that can manipulate specific regions of the brain using magnetic fields, potentially unlocking the secrets of high-level brain functions such as cognition, emotion, and motivation. The team has developed the world’s first Nano-MIND (Magnetogenetic Interface for NeuroDynamics) technology, which allows for wireless, remote, and precise modulation of specific deep brain neural circuits using magnetism.
The human brain contains over 100 billion neurons interconnected in a complex network. Controlling the neural circuits is crucial for understanding higher brain functions like cognition, emotion, and social behavior, as well as identifying the causes of various brain disorders. Novel technology to control brain functions also has implications for advancing brain-computer interfaces (BCIs), such as those being developed by Neuralink, which aim to enable control of external devices through thought alone.
While magnetic fields have long been used in medical imaging due to their safety and ability to penetrate biological tissue, precisely controlling brain circuits with magnetic fields has been a significant challenge for scientists.
In a scientific breakthrough, an international research team from Korea’s IBS Center for Quantum Nanoscience (QNS) and Germany’s Forschungszentrum Jülich developed a quantum sensor capable of detecting minute magnetic fields at the atomic length scale. This pioneering work realizes a long-held dream of scientists: an MRI-like tool for quantum materials.
The research team utilized the expertise of bottom-up single-molecule fabrication from the Jülich group while conducting experiments at QNS, utilizing the Korean team’s leading-edge instrumentation and methodological know-how to develop the world’s first quantum sensor for the atomic world.
The diameter of an atom is a million times smaller than the thickest human hair. This makes it extremely challenging to visualize and precisely measure physical quantities like electric and magnetic fields emerging from atoms. To sense such weak fields from a single atom, the observing tool must be highly sensitive and as small as the atoms themselves.
In a paper in Physical Review Letters scientists from the department Living Matter Physics at the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) propose a mechanism on how energy barriers in complex systems can be overcome. These findings can help to engineer molecular machines and to understand the self-organization of active matter.
Using two optically-trapped glass nanoparticles, researchers observed a novel collective Non-Hermitian and non-linear dynamic driven by non-reciprocal interactions. This contribution expands traditional optical levitation with tweezer arrays by incorporating non-conservative interactions.
A novel quantum sensor with exceptional resolution transforms atomic-level material analysis, paving the way for advancements in quantum technologies and sciences.
In a scientific breakthrough, an international research team from Germany’s Forschungszentrum Jülich and Korea’s IBS Center for Quantum Nanoscience (QNS) developed a quantum sensor capable of detecting minute magnetic fields at the atomic length scale. This pioneering work realizes a long-held dream of scientists: an MRI-like tool for quantum materials.
Quantum Sensor Development
Minimally invasive cellular-level target-specific neuromodulation is needed to decipher brain function and neural circuitry. Here nano-magnetogenetics using magnetic force actuating nanoparticles has been reported, enabling wireless and remote stimulation of targeted deep brain neurons in freely behaving animals.
In a scientific breakthrough, an international research team from Germany’s Forschungszentrum Jülich and Korea’s IBS Center for Quantum Nanoscience (QNS) developed a quantum sensor capable of detecting minute magnetic fields at the atomic length scale. This pioneering work realizes a long-held dream of scientists: an MRI-like tool for quantum materials.
The research team utilized the expertise of bottom up single-molecule fabrication from the Jülich group while conducting experiments at QNS, utilizing the Korean team’s leading-edge instrumentation and methodological know how, to develop the world’s first quantum sensor for the atomic world.
The diameter of an atom is a million times smaller than the thickest human hair. This makes it extremely challenging to visualize and precisely measure physical quantities like electric and magnetic fields emerging from atoms. To sense such weak fields from a single atom, the observing tool must be highly sensitive and as small as the atoms themselves.
The project, led by Professor Zhiqin Chu from the Department of Electrical and Electronic Engineering at the University of Hong Kong (HKU), and Professor Qiang Wei from Sichuan University, utilized label-free quantum sensing technology to measure cellular force at the nanoscale. This advancement surpasses the limitations of traditional cellular force measurement tools and provides new insights into cellular mechanics, particularly regarding how cellular adhesion forces affect cancer cell spreading.
The research team has developed a new Quantum-Enhanced Diamond Molecular Tension Microscopy (QDMTM) that offers an effective approach for studying cell adhesion forces. Compared to cell force measurement methods that utilize fluorescent probes, QDMTM has the potential to overcome challenges such as photobleaching, limited sensitivity, and ambiguity in data interpretation. Furthermore, QDMTM sensors can be cleaned and reused, enhancing the absolute accuracy of comparing cell adhesion forces across various samples.
