As scientists work toward moving in vivo CAR methods from concept to clinic, they must ensure that complex, multistep discovery and development workflows yield reliable and biologically meaningful data. In this article, learn more about materials for in vivo CAR discovery and development.
Learn more in this new issue of the TS Digest.
In vivo gene delivery, precise immune profiling, and robust quality controls reshape how researchers develop the next generation of CAR therapies.
A long-standing mystery in spintronics has just been shaken up. A strange electrical effect called unusual magnetoresistance shows up almost everywhere scientists look—even in systems where the leading explanation, spin Hall magnetoresistance, shouldn’t work at all. Now, new experiments reveal a far simpler origin: the way electrons scatter at material interfaces under the combined influence of magnetization and an electric field.
Researchers from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences (CAS), in collaboration with researchers from the Institute of Semiconductors of CAS, revealed anomalous oscillatory magnetoresistance in an antiferromagnetic kagome semimetal heterostructure and directly identified its corresponding topological magnetic structures. The results are published in Advanced Functional Materials.
Antiferromagnetic kagome semimetals, characterized by a strong interplay of geometric frustration, spin correlations, and band topology, have emerged as a promising platform for next-generation antiferromagnetic topological spintronics.
In this study, the researchers fabricated an FeSn/Pt heterostructure based on an antiferromagnetic kagome semimetal. By breaking inversion symmetry at the interface, the researchers introduced and tuned the Dzyaloshinskii-Moriya interaction, enabling effective control of spin configurations in the FeSn layer.
When we think about heat traveling through a material, we typically picture diffusive transport, a process that transfers heat from high-temperature to low-temperature as particles and molecules bump into each other, losing kinetic energy in the process. But in some materials, heat can travel in a different way, flowing like water in a pipeline that—at least in principle—can be forced to move in a direction of choice. This second regime is called hydrodynamic heat transport.
Heat conduction is mediated by movement of phonons, which are collective excitations of atoms in solids, and when phonons spread in a material without losing their momentum in the process, you have phonon hydrodynamics.
The phenomenon has been studied theoretically and experimentally for decades, but is becoming more interesting than ever to experimentalists because it features prominently in materials like graphene, and could be exploited to guide heat flow in electronics and energy storage devices.
The kind of light you use can reveal very different things about a material. Visible light mainly shows what is happening at the surface. X-rays can probe structures inside. Infrared light highlights the heat a material gives off.
Researchers at MIT have now turned to terahertz light to uncover quantum vibrations in a superconducting material, signals that scientists have not been able to observe directly until now.
From the article:
…in copper, the transition was extremely fast, taking about 26 attoseconds.
In the layered materials TiSe₂ and TiTe₂, the same process slowed to between 140 and 175 attoseconds. In CuTe, with its chain-like structure, the transition exceeded 200 attoseconds. These findings show that the atomic scale shape of a material strongly affects how quickly a quantum event unfolds, with lower symmetry structures leading to longer transition times.
Time may feel smooth and continuous, but at the quantum level it behaves very differently. Physicists have now found a way to measure how long ultrafast quantum events actually last, without relying on any external clock. By tracking subtle changes in electrons as they absorb light and escape a material, researchers discovered that these transitions are not instantaneous and that their duration depends strongly on the atomic structure of the material involved.
Quantum materials and superconductors are difficult enough to understand on their own. Unconventional superconductors, which cannot be explained within the framework of standard theory, take the enigma to an entirely new level. A typical example of unconventional superconductivity is strontium ruthenate, SRO214, the superconductive properties of which were discovered by a research team that included Yoshiteru Maeno, who is currently at the Toyota Riken—Kyoto University Research Center.
The findings are published in the journal Physical Review Letters.
Debate over SRO214’s superconducting nature.
For years researchers have tried to unlock the impressive underwater abilities of the diving bell spider, and new study details their best attempt yet.