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Category: life extension

Lifespan Extension Expert — AMA (pt.1)

Many people want to live longer than what is currently possible, but medical technology is not progressing fast enough. At Tomorrow Biostasis, we use the latest cryopreservation technology to medically preserve and protect you for as long as it is needed. When medical technology has solved the life extension and aging problems, you will be reanimated to enjoy an extended life.

On the YouTube channel of Tomorrow Biostasis you can find more information about the concepts of cryopreservation, cryonics, biostasis, vitrification, human revival, and more. We also provide you with practical information about signing up with Tomorrow Biostasis. Get ready to get an insight into the fascinating world of cryopreservation!

Visit our website at: https://bit.ly/35KsOIq.
Sign up for Biostasis: https://bit.ly/3hGb6sq.
Schedule a free Consultation: https://bit.ly/3IIwkll.

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#TomorrowBiostasis #Cryopreservation #Cryonics.

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AI And The Future Of Healthspan

Join us on Patreon! / michaellustgartenphd.

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs, for those who blood test with Quest): https://www.ultalabtests.com/partners… those who blood test with LabCorp: https://www.anrdoezrs.net/click-10161… At-Home Metabolomics: https://www.iollo.com?ref=michael-lus… Use Code: CONQUERAGING At Checkout Clearly Filtered Water Filter: https://get.aspr.app/SHoPY Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=… Use Code: CONQUERAGING NAD+ Quantification: https://www.jinfiniti.com/intracellul… Use Code: ConquerAging At Checkout Oral Microbiome: https://www.bristlehealth.com/?ref=mi… Enter Code: ConquerAging SiphoxHealth Blood Testing (ApoB, GrimAge): https://siphoxhealth.com/mlustgarten Green Tea: https://www.ochaandco.com/?ref=fqbtflod Use Code: ML10OFF Diet Tracking: https://shareasale.com/r.cfm?b=139013… If you’d like to support the channel, you can do that with the website, Buy Me A Coffee: https://www.buymeacoffee.com/mlhnrca Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-sprin…

Blood Testing Essentials (Biological Age, CVD-Risk, Kidney Health and Function):
PhenoAge (Biological Age): https://www.ultalabtests.com/partners…

Measure the Bortz biological clock biomarkers: https://www.ultalabtests.com/partners…

Calculate your biological age using the Bortz clock: https://www.longevity-tools.com/human…

International Group of Researchers Says We’re Thinking About Longevity at The Wrong Stage of Life

The science of longevity is an important topic for many researchers: how we might add years to our lifespans, and avoid disease and age-related decline at the same time.

There are a multitude of angles to approach the topic from too, whether it’s the genetics we’re born with or the food we eat along life’s journey.

Now, an international team of researchers is proposing that longevity interventions and research should start at the earliest ages possible – even before birth.

4D force patterning enables spatial control of angiogenesis

When the engineers used gene editing to suppress the PIEZO1 gene, the cells became “deaf” to the physical tugging. Even when the magnets vigorously exercised the gel, the blood vessels barely sprouted at all. This proved that physical force directly activates this cellular gatekeeper, signaling the vessel that it’s time to grow and branch out.

Engineering organized microvascular networks remains a critical challenge in tissue engineering and regenerative medicine. While biochemical approaches for patterning angiogenesis via growth factor delivery have shown promise, their inability to pattern sustained growth factors with spatiotemporal control limits effectiveness. Here, we demonstrate that dynamically patterned mechanical forces enable precise spatiotemporal control over angiogenic sprouting. We developed a magnetically actuated human vessel-on-a-chip platform that integrates a perfusable endothelialized microchannel within a collagen matrix and allows noninvasive and tunable mechanical stimulation across three spatial dimensions and time (4D). Using an automated 3-axis actuator, we systematically investigated how strain magnitude, frequency, and direction modulate endothelial cell behavior and vessel morphogenesis.

Aged Cells Can Revert Into Stem Cells To Regenerate Damaged Tissue

Welcome to functional immortality, folks.

I say functional rather than absolute because no one will ever REALLY live FOREVER. Even if we can reverse aging and become immune to all diseases (which is exactly what is happening right now even as I write this) there will still be accidents, suicides, wars, and murders. — Still…a BILLION years would be enough for me.

What about you?

A new study reveals that mature cells retain the ability to transform into stem cells after injury. The regenerative process, driven by macrophages, may offer new strategies for repairing damaged tissues.

Ovaries may take on job in immune system after their tenure as reproductive organs

For most women, the body begins to change dramatically in their 40s or 50s. This transition, known as menopause, is defined as 12 consecutive months without a menstrual period, marking the end of the reproductive years. While researchers are aware of the functions the ovaries perform during active reproductive years, what happens to the organ after menopause is largely a mystery.

A recent study in Molecular Human Reproduction investigated what happens to the ovary in mice after it stops producing eggs, a period known as the post-reproductive stage, similar to menopause in humans.

Researchers found that even after the ovary can no longer support reproduction, it doesn’t simply become inactive. Instead, aging ovaries undergo remarkable changes, producing a different set of signaling molecules from those of younger ovaries.

Dendrites may be key to learning and memory, study suggests

Branchlike structures called dendrites that extend from neurons appear to make their own computations independent of the cell body, helping individual brain cells store memories of the past, respond to the present and anticipate the future, a study led by UT Southwestern Medical Center researchers suggests.

The findings, published in Science, represent a paradigm shift in current models of how learning and memory take place.

“This shifts our entire perspective. Rather than acting as simple switches, neurons behave more like sophisticated processors with internal divisions of labor, dramatically increasing the brain’s computational capacity,” said Attila Losonczy, M.D., Ph.D., professor at the Peter O’Donnell Jr. Brain Institute of Neuroscience and director of the Program in Memory Longevity (PML) at UT Southwestern.

Breakdown of immune cells’ interaction is key driver in aging, study finds

We may age at different rates, but none of us escapes aging. A study in mice and human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell’s increasing inability, with advancing age, to gobble up another immune cell type.

So-called tissue-resident macrophages appear to be central coordinators of age-related organ decline. Blocking a single receptor on these cells preserved the youthfulness of multiple organs in mice, including the brain, heart, skeletal and heart muscle, liver, spleen, bone marrow, kidney and colon. The receptor binds specifically to a hormone known to cause inflammation and pain in humans as well as mice.

In mice, selectively disabling this receptor exclusively on tissue-resident macrophages prevented chronic inflammation-driven disorders of aging, including frailty, excessive fat accumulation and heart trouble. It also substantially slowed cognitive decline, said Katrin Andreasson, MD, the Edward F. and Irene Thiel Pimley professor of neurology and neurological sciences.

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