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In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a “low energy state,” which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity. #Food #DavidSinclair #Longevity

Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it’s never too late to slow the process of aging, and so much more.

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections. #DavidSinclair #Longevity #SkinCare T.

In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. #DavidSinclair #Longevity #Aging

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of “ex-differentiation” in which cells begin to lose their identity, and how all of this makes up the “Information Theory of Aging”, and the difference between “biological age” and “chronological age” and how we can measure biological age through DNA methylation clocks. #Aging #DavidSinclair #Longevity

In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine.

I describe the mechanisms by which different wavelengths of light impact the cells, tissues and organs of the human body, and how specifically timed light exposure of specific wavelengths can be used to improve sleep, enhance alertness, modulate hormone levels, and improve mood. I also explain the use of ultraviolet and infrared phototherapies to relieve pain increase testosterone and estrogen levels; improve skin health, appearance and wound healing; and how red light can be used to offset age-related vision loss and provide neuroprotection. Throughout the episode, I describe the mechanisms of light-based therapies and actionable tools that people can use positively impact mental and physical health.

The concept of biological immortality challenges the belief that death gives meaning to life and raises questions about the potential societal implications and ethical considerations of living indefinitely.

Questions to inspire discussion.

What is biological immortality?
—Biological immortality refers to the potential for humans to live indefinitely due to advancements in science and technology, leading to the elimination of age-related diseases and the aging process.

I like the chapter “would you want to be”.


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Ah, immortality, previously only for the gods and individuals with a fetish for chopping each other’s heads off. In more modern times, science is coming closer and closer to both identifying the tapestry of things that cause humans to grow old, and slowly but surely taking the first steps into finding ways to delay and even reverse this process for fun and profit. So, just what causes individuals of the human persuasion to grow old and die, who was the oldest confirmed human, are there any living things that are biologically immortal, and if there was an option to become biologically immortal, would you take it?

0:00 Intro.
3:42 The Oldest Human.
4:50 The Lobster.
9:01 It’s Not the Years Honey, It’s the Mileage.
13:32 Would You Want to Be Biologically Immortal?
17:24 The Senescent Cell Problem.
20:46 A Myriad of Other Factors.
26:04 The Biologically Immortal Creatures.

Author: Daven Hiskey.