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Could discovering how neural stem cells protect themselves from damage lead to treatment that helps combat aging?

We now know that stem cells in the brain do in fact divide, and that this regenerative capacity begins to falter with age. The majority of our cells don’t divide, and the bulk of division falls to stem cell niches dotted across our body. Stem cell populations do age, but they’re more resistant than ‘normal’ cells are, and they produce higher levels of telomerase — enabling them to divide for years.

How do brain stem cells remain free of damage?

Neural stem cells aren’t perfectly protected from aging, but they’re generally a hardier bunch. Scientists from the University of Zurich have now discovered that part of this aging resistance in neural stem cells is due to a ‘diffusion barrier’. When they divide, these cells produce a barrier which filters out damaged proteins to one side, allowing the new cell to be damage-free.

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Science usually approaches aging from a mechanical viewpoint, but could there be more to the story?


Why do so many scientists now believe that aging has been programmed by evolution?

Science usually approaches aging from a mechanical viewpoint, but the evolutionary theory of aging has gained more support as we observe the wide variation in aging between species.

The million dollar question: Why do we age?

Theories like the free radical theory of aging propose that aging is an inevitable process of being alive; that every day on this earth exposes the body to reactive chemicals, and aging is simply the gradual accumulation of damage. While we know the body does indeed accumulate forms of damage, the suggestion that this is inevitable is now being challenged.

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BioViva USA, Inc. has become the first company to treat a person with gene therapy to reverse biological aging, using a combination of two therapies developed and applied outside the United States of America. Testing and research on these therapies is continuing in BioViva’s affiliated labs worldwide.

BioViva CEO Elizabeth Parrish announced Biobthat the subject is doing well and has resumed regular activities. Preliminary results will be evaluated at 5 and 8 months with full outcome expected at 12 months. The patient will then be monitored every year for 8 years.

Gene therapy allows doctors to treat disease at the cellular level by inserting a gene into a patient’s cells instead of using the regular modalities of oral drugs or surgery. BioViva is testing several approaches to age reversal, including using gene therapy to introduce genes into the body.

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Call me skeptical. That said, who knows? It’s worth keeping an eye out for updates, at least.


Most of us might pray that the key to living forever will be found in our lifetime and, well, it has — according to one Russian scientist.

Anatoli Brouchkov reckons he has found the key to eternal life — but selfishly he isn’t going to let the rest of us try it out for ourselves.

The 58-year-old has injected himself with bacteria — and not any old bacteria either, this stuff is 3.5 BILLION years old.

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Pulitzer-prize winning science writer Jonathan Weiner writing about transhumanism and longevity issues:


Science writer Jonathan Weiner writes: Even if you’ve been following the presidential campaign pretty closely, you may not have heard about Zoltan Istvan, the hopeful from the newly formed Transhumanist Party. Istvan’s platform is simple: We should all live forever. He’s driving across the country in a bus painted to look like a coffin, with big white letters on its side: “Immortality Bus.”

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Visionary Liz Parrish shares some of the remarkable ways that genetic therapies are helping humanity transcend disease, aging and physical limitations. We discuss some of the current applications of gene therapy, what we can reasonably expect given the rate of progress and some of the moral implications of this science. If you’re anything like us, you’ll be astounded to hear about this work; it can already make you stronger and faster, and it may help future generations live upwards of 400 years!

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“Known as “the woman who wants to genetically engineer you,” Elizabeth Parrish is the CEO of BioViva USA Inc ™ she is a humanitarian, entrepreneur and innovator and a leading voice for genetic cures. As a strong proponent of progress and education for the advancement of gene therapy, she serves as a motivational speaker to the public at large for the life sciences. She is actively involved in international educational media outreach and sits on the board of the International Longevity Alliance (ILA). She is an affiliated member of the Complex Biological Systems Alliance (CBSA) whose mission is to further scientific understanding of biological complexity and the nature and origins of human disease. She is the founder of BioTrove Investments LLC and the BioTrove Podcasts which is committed to offering a meaningful way for people to learn about and fund research in regenerative medicine. She is also the Secretary of the American Longevity Alliance (ALA) a 501©(3) nonprofit trade association that brings together individuals, companies, and organizations who work in advancing the emerging field of cellular & regenerative medicine with the aim to get governments to consider aging a disease.” –Blurb taken from Liz’ LinkedIn Profile.

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Bill__0337This week’s episode welcomes Bill Andrew’s, Ph. D., President and Founder of the biotechnology firm Sierra Sciences. Bill is widely considered the foremost researcher on aging and telomeres and most of his entire professional career has been devoted to finding a cure for aging. Most notably, he led a team in 1997 at Geron Corporation to successfully identify the human enzyme telomerase. An enzyme that causes Telomeres to lengthen, thus enabling cells to replicate itself without hitting their Hayflick limit (i.e. the number of times a cell is able to reproduce itself). It is believed that only human embryonic stem cells and cancer cells are immortal and do not possess a Hayflick limit.

Our conversation explores the science, possibilities, and social impacts of finding a cure for aging. He explains his company’s quest to create a safe and affordable drug that will lengthen telomeres in every cell in your body. He believes his research team is one year away from starting human trials if he receives the additional funding necessary to finish his research.

Join us in this fascinating discussion that is sure to change the way you view aging and our future.

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