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UPDATE: A generous contribution of $5,000 from the Methuselah Foundation has been received! This will put the fundraiser over the top of the cost and pay for the advanced Champions Oncology treatment described below.

However, Dr. Coles still has other medical expenses outstanding, and more will be coming in.

To cover these as well as Dr. Coles’s many other personal expenses, the fundraiser will now have an extended timeframe and the limit has been raised to $20,000.

We are currently at $13,385 of our 20,000 goal! Help us make it all the way!

Your contribution would help Dr. Coles continue his contributions and be greatly appreciated.

*** PLEASE alert your friends. L Stephen Coles spend his entire professional career trying to save your life; take a second to help save his.***

CLICK HERE TO DONATE, OR TO HELP BY LIKING AND SHARING THE PAGE VIA FACEBOOK, TWITTER, GOOGLE+ OR PINTEREST.

Supporters

Methuselah Foundation

Offline Donation

donated $5,000.00

Friday, June 07, 2013

Anonymous

Offline Donation

donated $400.00

Friday, June 07, 2013

Chuck Wade

donated $20.00

Thursday, June 06, 2013

Anonymous

donated Hidden Amount

Wednesday, June 05, 2013

Tom Funk

donated $100.00

Wednesday, June 05, 2013

Gennady Stolyarov II

donated $50.00

Wednesday, June 05, 2013

Stephen Coles is one of the heroes of our time, who has contributed immensely to the prospects for longevity for all of us. I am honored to be able to assist him in his own struggle against a life-threatening illness, so that he could have decades and centuries more to fight the most dangerous, the most destructive enemies of senescence and death.Anonymous

Anonymous

donated $50.00

Tuesday, June 04, 2013

marshall zablen

donated $300.00

Tuesday, June 04, 2013

Anonymous

donated $200.00

Tuesday, June 04, 2013

Anonymous

donated $200.00

Tuesday, June 04, 2013

Björn Kleinert

donated $50.00

Tuesday, June 04, 2013

Get well !

Joao Pedro Magalhaes

donated $50.00

Tuesday, June 04, 2013

Anonymous

donated Hidden Amount

Monday, June 03, 2013

Otto

donated $20.00

Monday, June 03, 2013

Anonymous

donated $20.00

Monday, June 03, 2013

Franco Cortese

donated $100.00

Monday, June 03, 2013

PLEASE donate ANYTHING you can to help save the life of L. Stephen Coles, who has spent his entire professional career trying to save yours!

Aubrey de Grey

donated $300.00

Monday, June 03, 2013

Anonymous

Offline Donation

donated$5,000.00

Monday, June 03, 2013

RetirementSingularity.com

donated Hidden Amount

Monday, June 03, 2013

Anonymous

donated Hidden Amount

Monday, June 03, 2013

Sven Bulterijs

donated $15.00

Monday, June 03, 2013

Anonymous

donated Hidden Amount

Sunday, June 02, 2013

kg goldberger

donated $20.00

Sunday, June 02, 2013

prayers are on the way for more than 65% of deaths. Aging is a cause of adult cancer, stroke and many others age related diseases. Researchers fighting aging are the best people, they are fighting for all of us. Let’s pay them back!

Bijan Pourat MD

donated$250.00

Saturday, June 01, 2013

Maxim Kholin

donated Hidden Amount

Saturday, June 01, 2013

Aging is a disease. Aging is responsible

Anonymous

donated $60.00

Saturday, June 01, 2013

Nils Alexander Hizukuri

donated $30.00

Saturday, June 01, 2013

All the best!

Anonymous

donated $40.00

Saturday, June 01, 2013

Danny Bobrow

donated Hidden Amount

Saturday, June 01, 2013

Steve, win this fight for us all. I send you healing thoughts.

Danny

Steve, friends and family, but it is an outstanding, real-world example of the advancing frontier of science and medicine. The entire life-extension community should rally in support of this effort for Steve and for the acquisition of important scientific knowledge.

Cliff Hague

donated $100.00

Saturday, June 01, 2013

Best wishes for a speedy recovery.

Tom Coote

donated $100.00

Friday, May 31, 2013

With Best Wishes!

Anonymous

donated $100.00

Friday, May 31, 2013

Allen Taylor

donated$25.00

Friday, May 31, 2013

Gunther Kletetschka

donated Hidden Amount

Friday, May 31, 2013

john mccormack, Australia

donated $50.00

Friday, May 31, 2013

phil kernan

donated $100.00

Friday, May 31, 2013

Gary and Marie Livick

donated $100.00

Friday, May 31, 2013

ingeseim

donated Hidden Amount

Friday, May 31, 2013

TeloMe Inc.

donated $100.00

Friday, May 31, 2013

Not only is this an important cause for

-Preston Estep, Ph.D.

CEO and Chief Scientific Officer, TeloMe, Inc.

Not only is this an important cause for Steve, friends and family, but it is an outstanding, real-world example of the advancing frontier of science and medicine. The entire life-extension community should rally in support of this effort for Steve and for the acquisition of important scientific knowledge. –Preston Estep, Ph.D. CEO and Chief Scientific Officer, TeloMe, Inc.

Anonymous

donated $5.00

Thursday, May 30, 2013

Anonymous

donated $60.00

Thursday, May 30, 2013

Larry Abrams

donated $100.00

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Wednesday, May 29, 2013

*** PLEASE alert your friends—Our own continued health and longevity may depend on Steve continuing his work.***

This call for support was also posted by Ilia Stambler on the Longevity Alliance Website, and organized on YouCaring.com by John M. Adams. Eric Schulke has also helped tremendously in spreading the word about the Fundraiser.

Since founding the Los Angeles Gerontology Research Group in 1990, Dr. L. Stephen Coles M.D., Ph.D., has worked tirelessly to develop new ways to slow and ultimately reverse human aging.

Everyone active in the LA-GRG or the Worldwide GRG Discussion Group have benefited from his expertise. His continual reporting of news about the latest developments to the List and his work in areas such as gathering blood samples for a complete genome analysis of the oldest people in the world (supercentenarians, aged 110+) is ground breaking and far ahead of anything that has ever been accomplished before. Publication of this work is expected in collaboration with Stanford University before the end of the year. Other accomplishments are equally notable

CLICK HERE TO HELP!

BRIEF summary of his work: L. Stephen Coles, M.D. Ph.D — Cited in more than 250 scientific articles — Profiled as notable person in Wikipedia — Many other contributions to aging research and advancing long, healthy life

Steve Coles was diagnosed with Adenocarcinoma (Pancreatic Cancer) at the head of the pancreas on Christmas Eve of last year. Pancreatic cancer is particularly insidious. He underwent a Whipple (Surgical) Procedure on January 3rd that produced a beneficial result. The tumor’s complete obstruction to the common bile duct that had caused jaundice and severe pruritus (skin itching leading to scratching to the point of bleeding) was almost immediately reversed in two days. His subsequent chemotherapy with Gemzar over the past three months will hopefully prevent metastases from spreading to other organs. But we won’t know his prognosis until June 7th when a CT Scan will be compared with a baseline scan performed before the start of chemo interpreted by a cancer radiologist.

We now have the opportunity to carry out a personalized chemo treatment regimen created by a start-up company called Champions Oncology in Baltimore, MD; USA affiliated with the Johns Hopkins School of Medicine. Champions is a world class organization that will analyze the tissue sample that has already been sent to them. Then, a custom treatment program will be prescribed for Steve based on a mouse model, since each tumor is unique and pure test tube trials have not been shown to be effective.

Champions Oncology’s service is to test in mice what can work for Dr. Coles. This is done through two steps:

(1) To implant Dr. Coles’s cancer on mice. (This part has been successfully carried out, and it will allow us to test nine different treatment protocols on Dr. Coles’s specific tumor tissue in mice).

(2) Test the treatments on the mice (The treatments have been defined with Dr. James P. Watson, Dr. Coles, and his oncologists.)

Dr. Joao Pedro de Magalhes of Liverpool, UK was the first to propose employing the services of Champions Oncology. They have a good track record. The biggest risk is that the process normally takes so long that the patient dies before the results can be obtained (especially with such an aggressive, malignant cancer, as Dr. Coles’s). Luckily, this part went right. Also, there is a risk is that Step-1 won’t work. Luckily for us, this part went right, too. Therefore, so far, it seems that choosing Champions Oncology’s approach was the right choice. We can’t be sure that Step-2 will be as successful, but we need to try.

In addition to his medical team here in the U.S., our international friends have been active on his behalf. They successfully negotiated a 60 percent reduction in cost.

NOW, YOU CAN HELP IN TWO WAYS:

(1) CONTRIBUTE TO THIS FUND

Time is of the essence. The good people at Champions Oncology have agreed to begin the analysis immediately.

Steve Coles needs your support.

It may make THE difference. Please dig deep and support him by contributing to the fund.

*** Our own continued health and longevity may depend on Steve continuing his work.***

(2) SEND REFERRALS TO CHAMPIONS ONCOLOGY

Champions Oncology is an early-stage for-profit company. Champions is not a philanthropy. Like many companies offering breakthrough technologies, it has light bills to pay, payroll to make on time, and many other typical expenses.

Please think of any oncologists how may refer patients to Champions, then contact any of the individuals listed below so we may get life-saving information about Champions into their hands. Champions is particularly well set up to accommodate physicians and patients in the Eastern U.S., Germany, France, Brazil, and Japan.

We wish to acknowledge the GRG (the Gerontology Research Group—A discussion group of ~400 members worldwide.

We owe a special thank you to The International Longevity Alliance Movement for their support.

Contacts:

1. Edouard Debonneuil [email protected] France Skype ID: edebonneuil

2. Daniel Wuttke [email protected] Germany Skype: admiral_atlan

3. Ilia Stambler [email protected] Israel Skype: iliastam

4. John M. (Johnny) Adams [email protected]

U.S. (949) 922‑9786 Skype: agingintervention

Updates 06/03/2013

by John M. (Johnny) Adams

IMPORTANT MESSAGE: Dr. Coles has received a contribution and is forwarding it directly to Champions Oncology.

So as of now, 10:20 am PDT, we have $6175 of the needed $10,000!

I have contacted YouCaring and asked how to change the “$1475 raised of $10000 goal”.

Supporters

Franco Cortese

donated$100.00

Monday, June 03, 2013

PLEASE donate ANYTHING you can to help save the life of L. Stephen Coles, who has spent his entire professional career trying to save yours!

Aubrey de Grey

donated$300.00

Monday, June 03, 2013

Anonymous

Offline Donation

donated$5,000.00

Monday, June 03, 2013

RetirementSingularity.com

donated Hidden Amount

Monday, June 03, 2013

Anonymous

donated Hidden Amount

Monday, June 03, 2013

Sven Bulterijs

donated$15.00

Monday, June 03, 2013

Anonymous

donated Hidden Amount

Sunday, June 02, 2013

kg goldberger

donated$20.00

Sunday, June 02, 2013

prayers are on the way for more than 65% of deaths. Aging is a cause of adult cancer, stroke and many others age related diseases. Researchers fighting aging are the best people, they are fighting for all of us. Let’s pay them back!

Bijan Pourat MD

donated$250.00

Saturday, June 01, 2013

Maxim Kholin

donated Hidden Amount

Saturday, June 01, 2013

Aging is a disease. Aging is responsible

Anonymous

donated$60.00

Saturday, June 01, 2013

Nils Alexander Hizukuri

donated$30.00

Saturday, June 01, 2013

All the best!

Anonymous

donated$40.00

Saturday, June 01, 2013

Danny Bobrow

donated Hidden Amount

Saturday, June 01, 2013

Steve, win this fight for us all. I send you healing thoughts.

Danny Steve, friends and family, but it is an outstanding, real-world example of the advancing frontier of science and medicine. The entire life-extension community should rally in support of this effort for Steve and for the acquisition of important scientific knowledge.

Cliff Hague

donated $100.00

Saturday, June 01, 2013

Best wishes for a speedy recovery.

Tom Coote

donated $100.00

Friday, May 31, 2013

With Best Wishes!

Anonymous

donated$100.00

Friday, May 31, 2013

Allen Taylor

donated$25.00

Friday, May 31, 2013

Gunther Kletetschka

donated Hidden Amount

Friday, May 31, 2013

john mccormack, Australia

donated$50.00

Friday, May 31, 2013

phil kernan

donated$100.00

Friday, May 31, 2013

Gary and Marie Livick

donated$100.00

Friday, May 31, 2013

ingeseim

donated Hidden Amount

Friday, May 31, 2013

TeloMe Inc.

donated$100.00

Friday, May 31, 2013

Not only is this an important cause for

-Preston Estep, Ph.D.

CEO and Chief Scientific Officer, TeloMe, Inc.

Anonymous

donated$5.00

Thursday, May 30, 2013

Anonymous

donated$60.00

Thursday, May 30, 2013

Larry Abrams

donated$100.00

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Thursday, May 30, 2013

Anonymous

donated Hidden Amount

Wednesday, May 29, 2013

By Avi Roy, University of Buckingham

In rich countries, more than 80% of the population today will survive past the age of 70. About 150 years ago, only 20% did. In all this while, though, only one person lived beyond the age of 120. This has led experts to believe that there may be a limit to how long humans can live.

Animals display an astounding variety of maximum lifespan ranging from mayflies and gastrotrichs, which live for 2 to 3 days, to giant tortoises and bowhead whales, which can live to 200 years. The record for the longest living animal belongs to the quahog clam, which can live for more than 400 years.

If we look beyond the animal kingdom, among plants the giant sequoia lives past 3000 years, and bristlecone pines reach 5000 years. The record for the longest living plant belongs to the Mediterranean tapeweed, which has been found in a flourishing colony estimated at 100,000 years old.

This jellyfish never dies. Michael W. May

Some animals like the hydra and a species of jellyfish may have found ways to cheat death, but further research is needed to validate this.

The natural laws of physics may dictate that most things must die. But that does not mean we cannot use nature’s templates to extend healthy human lifespan beyond 120 years.

Putting a lid on the can

Gerontologist Leonard Hayflick at the University of California thinks that humans have a definite expiry date. In 1961, he showed that human skin cells grown under laboratory conditions tend to divide approximately 50 times before becoming senescent, which means no longer able to divide. This phenomenon that any cell can multiply only a limited number of times is called the Hayflick limit.

Since then, Hayflick and others have successfully documented the Hayflick limits of cells from animals with varied life spans, including the long-lived Galapagos turtle (200 years) and the relatively short-lived laboratory mouse (3 years). The cells of a Galapagos turtle divide approximately 110 times before senescing, whereas mice cells become senescent within 15 divisions.

The Hayflick limit gained more support when Elizabeth Blackburn and colleagues discovered the ticking clock of the cell in the form of telomeres. Telomeres are repetitive DNA sequence at the end of chromosomes which protects the chromosomes from degrading. With every cell division, it seemed these telomeres get shorter. The result of each shortening was that these cells were more likely to become senescent.

Other scientists used census data and complex modelling methods to come to the same conclusion: that maximum human lifespan may be around 120 years. But no one has yet determined whether we can change the human Hayflick limit to become more like long-lived organisms such as the bowhead whales or the giant tortoise.

What gives more hope is that no one has actually proved that the Hayflick limit actually limits the lifespan of an organism. Correlation is not causation. For instance, despite having a very small Hayflick limit, mouse cells typically divide indefinitely when grown in standard laboratory conditions. They behave as if they have no Hayflick limit at all when grown in the concentration of oxygen that they experience in the living animal (3–5% versus 20%). They make enough telomerase, an enzyme that replaces degraded telomeres with new ones. So it might be that currently the Hayflick “limit” is more a the Hayflick “clock”, giving readout of the age of the cell rather than driving the cell to death.

The trouble with limits

Happy last few days? It doesn’t have to end this way. ptimat

The Hayflick limit may represent an organism’s maximal lifespan, but what is it that actually kills us in the end? To test the Hayflick limit’s ability to predict our mortality we can take cell samples from young and old people and grow them in the lab. If the Hayflick limit is the culprit, a 60-year-old person’s cells should divide far fewer times than a 20-year-old’s cells.

But this experiment fails time after time. The 60-year-old’s skin cells still divide approximately 50 times – just as many as the young person’s cells. But what about the telomeres: aren’t they the inbuilt biological clock? Well, it’s complicated.

When cells are grown in a lab their telomeres do indeed shorten with every cell division and can be used to find the cell’s “expiry date”. Unfortunately, this does not seem to relate to actual health of the cells.

It is true that as we get older our telomeres shorten, but only for certain cells and only during certain time. Most importantly, trusty lab mice have telomeres that are five times longer than ours but their lives are 40 times shorter. That is why the relationship between telomere length and lifespan is unclear.

Apparently using the Hayflick limit and telomere length to judge maximum human lifespan is akin to understanding the demise of the Roman empire by studying the material properties of the Colosseum. Rome did not fall because the Colosseum degraded; quite the opposite in fact, the Colosseum degraded because the Roman Empire fell.

Within the human body, most cells do not simply senesce. They are repaired, cleaned or replaced by stem cells. Your skin degrades as you age because your body cannot carry out its normal functions of repair and regeneration.

To infinity and beyond

If we could maintain our body’s ability to repair and regenerate itself, could we substantially increase our lifespans? This question is, unfortunately, vastly under-researched for us to be able to answer confidently. Most institutes on ageing promote research that delays onset of the diseases of ageing and not research that targets human life extension.

Those that look at extension study how diets like calorie restriction affect human health or the health impacts of molecules like resveratrol derived from red wine. Other research tries to understand the mechanisms underlying the beneficial effects of certain diets and foods with hopes of synthesising drugs that do the same. The tacit understanding in the field of gerontology seems to be that, if we can keep a person healthy longer, we may be able to modestly improve lifespan.

Living long and having good health are not mutually exclusive. On the contrary, you cannot have a long life without good health. Currently most ageing research is concentrated on improving “health”, not lifespan. If we are going to live substantially longer, we need to engineer our way out of the current 120-year-barrier.

Avi Roy does not work for, consult to, own shares in or receive funding from any company or organisation that would benefit from this article, and has no relevant affiliations.

Read the original article.

The following article was originally published by Immortal Life

When asked what the biggest bottleneck for Radical or Indefinite Longevity is, most thinkers say funding. Some say the biggest bottleneck is breakthroughs and others say it’s our way of approaching the problem (i.e. that we’re seeking healthy life extension whereas we should be seeking more comprehensive methods of indefinite life-extension), but the majority seem to feel that what is really needed is adequate funding to plug away at developing and experimentally-verifying the various, sometimes mutually-exclusive technologies and methodologies that have already been proposed. I claim that Radical Longevity’s biggest bottleneck is not funding, but advocacy.

This is because the final objective of increased funding for Radical Longevity and Life Extension research can be more effectively and efficiently achieved through public advocacy for Radical Life Extension than it can by direct funding or direct research, per unit of time or effort. Research and development obviously still need to be done, but an increase in researchers needs an increase in funding, and an increase in funding needs an increase in the public perception of RLE’s feasibility and desirability.

There is no definitive timespan that it will take to achieve indefinitely-extended life. How long it takes to achieve Radical Longevity is determined by how hard we work at it and how much effort we put into it. More effort means that it will be achieved sooner. And by and large, an increase in effort can be best achieved by an increase in funding, and an increase in funding can be best achieved by an increase in public advocacy. You will likely accelerate the development of Indefinitely-Extended Life, per unit of time or effort, by advocating the desirability, ethicacy and technical feasibility of longer life than you will by doing direct research, or by working towards the objective of directly contributing funds to RLE projects and research initiatives. Continue reading “Longevity’s Bottleneck May Be Funding, But Funding’s Bottleneck is Advocacy & Activism” | >

Dirrogate_fundawear_memories_with_maya

Emotions and Longevity:

If the picture header above influenced you to click to read more of this article, then it establishes at least part of my hypothesis: Visual stimuli that trigger our primal urges, supersede all our senses, even over-riding intellect. By that I mean, irrespective of IQ level, the visual alone and not the title of the essay will have prompted a click through –Classic advertising tactic: Sex sells.

Yet, could there be a clue in this behavior to study further, in our quest for Longevity? Before Transhumanism life extension technology such as nano-tech and bio-tech go mainstream… we need to keep our un-amped bodies in a state of constant excitement, using visual triggers that generate positive emotions, thereby hopefully, keeping us around long enough to take advantage of these bio-hacks when they become available.

dirrogate_emotion_transhumanism

Emotions on Demand — The “TiVo-ing” of feelings:

From the graphic above, it is easy to extrapolate that ‘positive’ emotions can contribute significantly to Longevity. When we go on a vacation, we’re experiencing the world in a relaxed frame of mind and encoding these experiences, even if sub-consciously, in our brains (minds?). Days, or even years later we can call on these experiences, on-demand, to bring us comfort.

Granted, much like analog recordings… over time, these stored copies of positive emotions will deteriorate, and just as we can today digitize images and sounds, making for pristine everlasting copies… can we digitize Emotions for recall and to experience them on-demand?

How would we go about doing it and what purpose does it serve?

durex_fundawear_dirrogate_sex

Digitizing Touch: Your Dirrogate’s unique Emotional Signature:

Can we digitize Touch; a crucial building block that contributes to the creation of Emotions? For an answer, we need to look to the (and to some, the questionable) technology behind Teledildonics.

While the tech to experience haptic feed-back has been around for a while, it’s been mostly confined to Virtual Reality simulations and for training purposes. Crude haptic-force feedback gaming controllers are available on the market, but advances in actuators, and nano-scale miniaturization are soon to change that, even going as far as to give us tactile imaging capability — “Smart Skin

Recently, Durex announced “Fundawear”. It’s purpose? To experience the “touch” of your partner in a fun light-hearted way. Yet, what if a Fundawear session could be recorded and played back later? The unique way your partner touches, forever digitized for playback when desired… allowing you to experience the emotion of joy and happiness at will?

Fundawear can be thought of as a beta v1.0 of something akin to smart-skin in reverse, which could eventually allow a complete “feel-stream” to be digitized and played back on-demand.

Currently we are already able to digitize some faculties that stimulate two of our primary senses:

  • Sight — via a video camera.
  • Sound — via microphones.

So how do we go about digitizing and re-creating the sense of Touch?

Solutions such as the one from NuiCapture shown in the video above, in combination with off the shelf game hardware such as the Kinect, can Digitize a whole body “performance” — Also known as performance capture.

Dirrogates and 3D Printing a Person:

In the near future if we get blue-prints to 3D print a person, ready for re-animation and complete with “smart-skin”… such a 3D printed surrogate could reciprocate our touch.

It would be an exercise in imagination, to envision 3D printing your partner, if they couldn’t be with you when you wanted them, or indeed it could raise moral and ethical issues such as ‘adultery’ if an un-authorized 3D printed copy was produced of a person, and their “signature” performance files was pirated.

But with every evil, there is also the good. 3D printers can print guns, or as seen in the video above: a prosthetic hand, allowing a child to experience life the way other children do — That is the ethos of Transhumanism.

3d-tv-family-conference

Loneliness can kill you:

Well maybe not exactly kill you, but it can negatively impact your health, says The World of Psychology. That would be counterproductive in our quest for Longevity.

A few years ago, companies such as Accenture introduced family collaboration projects. I recommend clicking on the link to read the article, as copyright restrictions prevent including it in this essay. In essence, it allows older relatives to derive emotional comfort from seeing and interacting with their families living miles away.

At a very basic level, we are already Transhuman. No stigma involved… no religious boundaries crossed. This ethical use of technology, can bring comfort to an aging section of society, bettering their condition.

In a relationship, the loss of a loved one can be devastating to the surviving partner, even more so, if the couple had grown old together and shared their good and bad times. Experiencing and re-living memories that transcend photographs and videos, could contribute towards generating positive emotions and thus longevity in the person coping with his/her loss.

While 3D printing and re-animating a person is still a few years away, there is another stop-gap technology: Augmented Reality. With AR visors, we can see and interact with a “Dirrogate” (Digital Surrogate) of another person as though they were in the same room with us. The person’s Dirrogate can be operated in real-time by another person living thousands of miles away… or a digitized touch stream can be called on… long after the human operator is no more.

In the story: “Memories with Maya”, the context and it’s repercussion on our evolution into a Transhuman species, is explored in more detail.

The purpose of this essay is to seed ideas only, and is not to be taken as expert advice.

1inftri

Immortal Life is presenting a public event in Washington D.C., titled “Radical Life Extension: are you ready to live 1,000 years?”

It will take place in the historic Friends Meeting House on September 22 (Sunday). The event will be from 5:30–7:30.

We will have 10–12 speakers discussing Immortality / Life Extension from a wide variety of perspectives: scientific, political, social, poetic, religious, atheistic, economic, demographic, moral, etc.

Our lineup of speakers even features numerous Lifeboat Foundation Advisors , including myself, Gabriel Rothblatt, Hank Pellissier, Antonei B. Csoka, and Didier Coeurnelle. Other speakers include Mark Waser, Gray Scott, Jennifer ‘Dotora’ Huse, Apneet Jolly, Tom Mooney, Hank Fox, Maitreya One Paul Spiegel and Rich Lee.

There are still a few available slots for speakers but they’re filling fast, so if you’re interested in reserving a seat, being a speaking or contributing in any other way, please have them send an email to [email protected]

We have already attained the support of numerous life extension groups in the Washington DC area, but are always grateful for funding contributions from sponsors to help us with travel and advertising costs, and speaker stipends, for this event and future events. Promoters are always welcome as well.

Medical science has changed humanity. It changed what it means to be human, what it means to live a human life. So many of us reading this (and at least one person writing it) owe their lives to medical advances, without which we would have died.

Live expectancy is now well over double what it was for the Medieval Briton, and knocking hard on triple’s door.

What for the future? Extreme life extension is no more inherently ridiculous than human flight or the ability to speak to a person on the other side of the world. Science isn’t magic – and ageing has proven to be a very knotty problem – but science has overcome knotty problems before.

A genuine way to eliminate or severely curtail the influence of ageing on the human body is not in any sense inherently ridiculous. It is, in practice, extremely difficult, but difficult has a tendency to fall before the march of progress. So let us consider what implications a true and seismic advance in this area would have on the nature of human life.

keep-calm-and-be-forever-young-138

One absolutely critical issue that would surround a breakthrough in this area is the cost. Not so much the cost of research, but the cost of application. Once discovered, is it expensive to do this, or is it cheap? Do you just have to do it once? Is it a cure, or a treatment?

If it can be produced cheaply, and if you only need to do it once, then you could foresee a future where humanity itself moves beyond the ageing process.

The first and most obvious problem that would arise from this is overpopulation. A woman has about 30–35 years of life where she is fertile, and can have children. What if that were extended to 70–100 years? 200 years?

Birth control would take on a vastly more important role than it does today. But then, we’re not just dropping this new discovery into a utopian, liberal future. We’re dropping it into the real world, and in the real world there are numerous places where birth control is culturally condemned. I was born in Ireland, a Catholic nation, where families of 10 siblings or more are not in any sense uncommon.

What of Catholic nations – including some staunchly conservative, and extremely large Catholic societies in Latin America – where birth control is seen as a sin?

Of course, the conservatism of these nations might (might) solve this problem before it arises – the idea of a semi-permanent extension of life might be credibly seen as a deeper and more blasphemous defiance of God than wearing a condom.

But here in the West, the idea that we are allowed to choose how many children we have is a liberty so fundamental that many would baulk to question it.

We may have to.

quizzical baby

There is another issue. What about the environmental impact? We’re already having a massive impact on the environment, and it’s not looking pretty. What if there were 10 times more of us? 100 times more? What about the energy consumption needs, in a world running out of petrol? The food needs? The living space? The household waste?

There are already vast flotillas of plastic waste the size of small nations that float across the surface of the Pacific. Carbon dioxide levels in the atmosphere have just topped 400 parts per million. We are pushing hard at the envelope of what the world of capable of sustaining, and a massive boost in population would only add to that ever-increasing pressure.

Of course, science might well sort out the answer to those things – but will it sort it out in time? The urgency of environmental science, and cultural change, suddenly takes on a whole new level of importance in the light of a seismic advance in addressing the problem of human ageing.

These are problems that would arise if the advance produced a cheap treatment that could (and would) be consumed by very large numbers of people.

But what if it wasn’t a cure? What if it wasn’t cheap? What if it was a treatment, and a very expensive one?

All of a sudden, we’re looking at a very different set of problems, and the biggest of all centres around something Charlie Chaplin said in the speech he gave at the end of his film, The Great Dictator. It is a speech from the heart, and a speech for the ages, given on the eve of mankind’s greatest cataclysm to date, World War 2.

In fact, you’d be doing yourself a favour if you watched the whole thing, it is an astounding speech.

chaplin great dictator

The quote is this:

“To those who can hear me, I say — do not despair.

The misery that is now upon us is but the passing of greed, the bitterness of men who fear the way of human progress. The hate of men will pass, and dictators die, and the power they took from the people will return to the people. And so long as men die, liberty will never perish.”

And so long as men die, liberty will never perish.

What if Stalin were immortal? And not just immortal, but immortally young?

Immortally vigourous, able to amplify the power of his cult of personality with his literal immortality.

This to me seems a threat of a very different kind, but of no less importance, than the dangers of overpopulation. That so long as men die, liberty will never perish. But what if men no longer die?

And of course, you could very easily say that those of us lucky enough to live in reasonably well-functioning democracies wouldn’t have to worry too much about this. It doesn’t matter if you live to be 1000, you’re still not getting more than 8 years of them in the White House.

But there is something in the West that would be radically changed in nature. Commercial empires.

What if Rupert Murdoch were immortal?

It doesn’t matter how expensive that treatment for ageing is. If it exists, he’d be able to afford it, and if he were able to buy it, he’d almost certainly do so.

If Fox News was run by an immortal business magnate, with several lifetimes worth of business experience and skill to know how to hold it all together, keep it going, keep it growing? What then?

Charles-Montgomery-Burns--007

Not perhaps the sunny utopia of a playground of immortals that we might hope for.

This is a different kind of issue. It’s not an external issue – the external impact of population on the environment, or the external need of a growing population to be fed. These problems might well sink us, but science has shown itself extremely adept at finding solutions to external problems.

What this is, is an internal problem. A problem of humanity. More specifically, the fact that extreme longevity would allow tyranny to achieve a level of entrenchment that it has so far never been capable of.

But then a law might be passed. Something similar to the USA’s 8 year term limit on Presidents. You can’t be a CEO for longer than 30 years, or 40 years, or 50. Something like that might help, might even become urgently necessary over time. Forced retirement for the eternally young.

Not an unproblematic idea, I’m sure you’ll agree. Quite the culture shock for Western societies loathe to accept government intervention in private affairs.

But it is a new category of problem. A classic problem of humanity, amplified by immortality. The centralisation of control, power and influence in a world where the people it centres upon cannot naturally die.

This, I would say, is the most obvious knotty problem that would arise, for humanity, in the event of an expensive, but effective, treatment for ageing.

But then, let’s just take a quick look back at the other side of the coin. Is there a problem inherent in humanity that would be amplified were ageing to be overcome, cheaply, worldwide?

Let me ask you a question.

Do people, generally speaking, become more open to new things, or less open to new things, as they age?

Do older people – just in general terms – embrace change or embrace stasis?

Well, it’s very obvious that some older people do remain young at heart. They remain passionate, humble in their beliefs, they are open to new things, and even embrace them. Some throw the influence and resources they have accrued throughout their lifetimes into this, and are instrumental to the march of progress.

More than this, they add a lifetime of skill, experience and finesse to their passion, a melding of realism and hope that is one of the most precious and potent cocktails that humanity is capable of mixing.

But we’re not talking about the few. We’re talking about the many.

Is it fair to say that most older people take this attitude to change? Or is it fairer to say that older people who retain that passion and spark, who not only have retained it, but have spent a lifetime fuelling it into a great blaze of ability and success – is it fair to say that these people are a minority?

I would say yes. They are incredibly precious, but part of that preciousness is the fact that they are not common.

Perhaps one day we will make our bodies forever young. But what of our spirit? What of our creativity?

I’m not talking about age-related illnesses like Parkinson’s, or Alzheimer’s disease. I’m talking about the creativity, passion and fire of youth.

The temptation of the ‘comfort zone’ for all human beings is a palpable one, and one that every person who lives well, who breaks the mold, who changes the future, must personally overcome.

Do the majority of people overcome it? I would argue no. And more than this, I would argue that living inside a static understanding of the world – even working to protect that understanding in the face of naked and extreme challenges from reality itself – is now, and has historically been, through all human history, the norm.

Those who break the mold, brave the approbation of the crowd, and look to the future with wonder and hope, have always been a minority.

mind closed till further notice

Now add in the factor of time. The retreat into the comforting, the static and the known has a very powerful pull on human beings. It is also not a binary process, but an analogue process – it’s not just a case of you do or you don’t. There are degrees of retreat, extremes of intellectual conservatism, just as there are extremes of intellectual curiosity, and progress.

But which extremes are the more common? This matters, because if all people could live to 200 years old or more, what would that mean for a demographic shift in cultural desire away from change and toward stasis?

A worrying thought. And it might seem that in the light of all this, we should not seek to open the Pandora’s box of eternal life, but should instead stand against such progress, because of the dangers it holds.

But, frankly, this is not an option.

The question is not whether or not human beings should seek to conquer death.

The question is whether or not conquering death is possible.

If it is possible, it will be done. If it is not, it will not be.

But the obvious problem of longevity – massive population expansion – is something that is, at least in principle, amenable to other solutions arising from science as it now practiced. Cultural change is often agonising, but it does happen, and scientific progress may indeed solve the issues of food supply and environmental impact. Perhaps not, but perhaps.

At the very least, these sciences take on a massively greater importance to the cohesion of the human future than they already have, and they are already very important indeed.

But there is another, deeper problem of a very different kind. The issue of the human spirit. If, over time, people (on average) become more calcified in their thinking, more conservative, less likely to take risks, or admit to new possibilities that endanger their understanding, then longevity, distributed across the world, can only lead to a culture where stasis is far more valued than change.

Pandora’s box is already open, and its name is science. Whether it is now, or a hundred years from now, if it is possible for human beings to be rendered immortal through science, someone is going to crack it.

We cannot flinch the future. It would be churlish and naive to assume that such a seemingly impossible vision will forever remain impossible. Not after the last century we just had, where technological change ushered in a new era, a new kind of era, where the impossibilities of the past fell like wheat beneath a scythe.

Scientific progress amplifies the horizon of possible scientific progress. And we stand now at a time when what it means to be a human – something which already undergone enormous change – may change further still, and in ways more profound than any of us can imagine.

If it can be done, it will be done. And so the only sane approach is to look with clarity at what we can see of what that might mean.

The external problems are known problems, and we may yet overcome them. Maybe. If there’s a lot of work, and a lot of people take a lot of issues a lot more seriously than they are already doing.

climate-change-silence-630

But there is a different kind of issue. An issue extending from human nature itself. Can we overcome, as a people, as a species, our fear, and the things that send us scurrying back from curiosity and hope into the comforting arms of wilful ignorance, and static belief?

This, in my opinion, is the deepest problem of longevity. Who wants to live forever in a world where young bodies are filled with withered souls, beaten and embittered with the frustrations of age, but empowered to set the world in stone to justify them?

But perhaps it was always going to come to this. That at some point technological advancement would bring us to a kind of reckoning. A reckoning between the forces of human fear, and the value of human courage.

To solve the external problems of an eternal humanity, science must do what science has done so well for so long – to delve into the external, to open up new possibilities to feed the world, and balance human presence with the needs of the Earth.

But to solve the internal problems of an eternal humanity, science needs to go somewhere else. The stunning advances in the understanding of the external world must begin to be matched with new ways of charting the deeps of human nature. The path of courage, of open-mindedness, of humility, and a willingness to embrace change and leave behind the comforting arms of old static belief systems – this is not a path that many choose.

But many more must choose it in a world of immortal people, to counterbalance the conservatism of those who fail the test, and retreat, and live forever.

Einstein lived to a ripe old age, and never lost his wonder. Never lost his humility, or his courage to brave the approbation and ridicule of his peers in that task he set himself. To chart the deep simplicities of the real, and know the mind of God. The failure of the human spirit is not written in the stars, and never will be.

einstein laughing

We are none of us doomed to fail in matters of courage, curiosity, wonder or hope. But we are none of us guaranteed to succeed.

And as long as courage, hope and the ability to break new ground remain vague, hidden properties that we squeamishly refuse to interrogate, each new generation will have to start from scratch, and make their own choices.

And in a world of eternal humans, if any individual generation fails, the world will be counting that price for a very long time.

It is a common fear that if we begin to make serious headway into issues normally the domain of the spiritual, we will destroy the mystique of them, and therefore their preciousness.

Similar criticisms were, and sometimes still are, laid at the feet of Darwin’s work, and Galileo’s. But the fact is that an astronomer does not look to the sky with less wonder because of their deeper understanding, but more wonder.

Reality is both stunningly elegant, and infinitely beautiful, and in these things it is massively more amazing than the little tales of mystery humans have used to make sense of it since we came down from the trees.

In the face of a new future, where the consequences of human courage and human failure are amplified, the scientific conquest of death must be fused with another line of inquiry. The scientific pioneering of the fundamental dynamics of courage in living, and humility to the truth, over what we want to believe.

It will never be a common path, and no matter how clear it is made, or how wide it is opened, there will always be many who will never walk it.

But the wider it can be made, the clearer it can be made, the more credible it can be made as an option.

And we will need that option. We need it now.

And our need will only grow greater with time.

By Avi Roy, University of Buckingham

I want to live longer and help others do the same. I assumed the most effective way to do that is by understanding the science of aging and then engineering solutions to extend human lifespan. That is why I became a biomedical researcher and over the past several years I have pursued this goal almost single-mindedly.

When a 2004 study showed that reducing the calorie intake in mice extended their life by 42%, I enthusiastically embraced the results and even put myself on a calorie restricted diet. But, subsequently, a 2012 study showed that long-term calorie restriction may not have the promised benefits. On the contrary, fewer calories without the required nutrients might actually cause harm.

Calorie restriction is not the first such “promising” route that eventually did not live up to the promise, and it will not be the last. Antioxidants showed promise in holding back diseases caused by aging, but now we know that antioxidant supplements are more likely to shorten your life.

Earlier in May, researchers showed that reducing a protein called NF-kB in mouse brains modestly improved their lifespan. I am not holding out for this result either. Before too long, I’m sure there will be reports of severe side effects of manipulating levels of NF-kB.

Take it easy

Looking at the data I have come to the conclusion that “doing nothing” may be the best option in most cases. This may not be as pessimistic as it sounds and it is definitely not to say that research in fighting aging must not be carried out.

When I say “do nothing”, I am assuming that you do not smoke or drink too much alcohol, and have access to medical care in case of injury. Such measures are bound to increase your lifespan.

But currently, not intervening in the aging process is more likely to help you live longer than trying any of the methods I’ve mentioned, not by a few months but by many years. Trying any of those interventions may actually cause harm, and will do so for the foreseeable future.

Lesson from the past

The chart below shows the survival rates – the percentage of the population that lives to a certain age – for men in England and Wales from 1860 to 2010.

In the 1860s, more than 20% of children died at birth or soon after. On average, men’s health started to decline around the age of 30, and only about 20% of the population survived for more than 70 years.

By 1910, child mortality decreased, thanks to improvements in hygiene and better medical care. This meant more men lived past the age of 50. Circle A shows this reduction in childhood mortality between 1860 and 2010. But, as can be seen from Circle D, the gain towards the end was not significant. This is because only 30% of males passed the age of 70.

Fifty years later, after the discovery of penicillin and invention of more vaccines, 90% of English and Welsh men lived until 50, and more than half survived to 70. Arrow B marks this trend.

Today almost 80% of men live to the age of 70. Four times as many men reach 70 now than in 1860.

What accounts for the change? Between 1860 and 1960, the significant increase in survival rate was due to medical intervention. Since 1960, the survival curve has improved mainly due to reduction in smoking.

This trend is similar in many rich countries, including the US. Druin Burch, a physician and writer, says in his book Taking the Medicine, that eliminating smoking would provide more benefits than being able to cure people of every possible type of cancer.

Age gracefully

Many experts believe that human lifespan might actually have an upper limit of 125 years. The average may not increase much beyond 90. If we are to agree with them, this leaves little room for improvement.

But we have never concentrated on maximising human lifespan before. Most people believe human lifespan is finite, so all drugs being manufactured today are targeted towards certain age-related diseases such as diabetes and hypertension. They are not designed to extend human lifespan.

If this bleak outlook is indeed true, we should not practise naive interventionism because it is unlikely to help. As Nassim Nicholas Taleb describes in his book Antifragile, naive interventionism occurs when we try to fix a single thing, but end up disturbing a complex system.

In case of extending human lifespan, those naive interventions would include calorie restriction, antioxidant supplements or manipulating the protein NF-kB, as mentioned earlier. They also include the current obsession with replacing fat in foods with sugar, the health benefits of drinking red wine, or the use ofsurgery or supplements to “fight” aging. This latter industry has grown in the past decade from being non-existent to an estimated worth of $88 billion today.

If intervening in the aging process with current biomedical science has any positive effect at all, it will be far too small to worry about. It’s far more likely to harm us.

That is why I have decided to do nothing and follow a simple rule: unless I meet with an accident, or suffer from a terminal disease, I will not add anything to my life with the explicit purpose of extending it. To do anything else would most likely do more harm than good.

Avi Roy does not work for, consult to, own shares in or receive funding from any company or organisation that would benefit from this article, and has no relevant affiliations.

The Conversation

This article was originally published at The Conversation.
Read the original article.

Le Petit Trépas

One common argument against Radical Life Extension is that a definitive limit to one’s life – that is, death – provides some essential baseline reference, and that it is only in contrast to this limiting factor that life has any meaning at all. In this article I refute the argument’s underlying premises, and then argue that even if such premises were taken as true, its conclusion – that eradicating death would negate the “limiting factor” that legitimizes life — is also invalid.

Death gives meaning to life? No! Death makes life meaningless!

One version of the argument, which I’ve come across in a variety of places, is given in Brian Cooney’s Posthuman, an introductory philosophical text that uses various futurist scenarios and concepts to illustrate the broad currents of Western Philosophy. Towards the end he makes his argument against immortality, claiming that if we had all the time in the universe to do what we wanted, then we wouldn’t do anything at all. Essentially, his argument boils down to ‘if there is no possibility of not being able to do something in the future, then why would we ever do it?”.

This assumes that we make actions on the basis of not being able to do them again. But people don’t make decisions this way. We didn’t go out to dinner because the restaurant was closing down… we went out for dinner because we wanted to go out for dinner… I think that Cooney’s version of the argument is naïve. We don’t make the majority of our decisions by contrasting an action to the possibility of not being able to do it in future.

His argument seems to be that if there were infinite time then we would have no way of prioritizing our actions. If we had a list of all possible actions set before us, and time were limitless, we might (according to his logic) accomplish all the small, negligible things first, because they’re easier and all the hard things can wait. If we had all the time in the world, we would have no reference point with which to judge how important a given action or objective is, which ones it is most important to get done, and which ones should get done in the place of other possibilities. If we really can do every single thing on that listless list, then why bother, if each is as important as every other? In his line-of-reasoning, importance requires scarcity. If we can do everything it were possible to do, then there is nothing that determines one thing as being more important than another. A useful analogy might be that current economic definitions of value require scarcity. If everything were as abundant as everything else, if nothing were scarce, then we would have no way of ascribing economic value to a given thing, such that one thing has more economic value than another. What we sometimes forget is that ecologies aren’t always like economies.

Seethe of Sooth and Teethe of Truth

Where could this strange notion have come from? That death would give meaning to life… Is it our intuitions, having picked up on the fact that we usually draw conclusions and make final and definitive interpretations when a given thing is finished (e.g. we wait until the book is done before we decide whether it was good or bad)? Is it because we feel that lives, much like stories, need a definitive end to be true, and that something must be true to matter?

Could this (at least partly) come from the long philo-socio-historical tradition of associating truth and meaning with staticity and non-change? It makes seeming sense that we would rather truth not be squirming around on our hand while we’re looming for a better view. If truth is stillborn and stable, then we can make pronouncements we feel won’t dissipate as soon as they’ve left the tongue. If truth is motionless, then we might just be able to get a handle on it. If it’s running about like a wild animal, then any attempt to make or to discover truth might be murdered remorselessly by truth’s newest transformation. Corpses are easier to keep canned in ken than runny kids, after all.

If something can go on towards infinity then there is no time that it will stop moving, no time it will come definitively to rest and say ‘I am this.’ If we don’t have an end to curtail the reverse-comet-tail of our foreward rail, no last-exit exhale, never to come to rest so as to rest in one definitive piece, then we won’t ever be static enough to fit this vile definition of truth-as-staticity. This rank association of truth with being-at-rest has infected our very language: thus to go in a straight line without wavering is to keep true.

So this memetic foray has yielded a possible line-of-conceptual-association. We must have an end to be still, we must be still to have truth, and we must have truth to matter at all. Perhaps. There is no telling without a look at the till, and unfortunately it’s been taken by the wind.

If truth is that which does in fact exist, if truth is existence, then they’ve committed a dire irony by grounding truth in ground instead of sky, in the ironed smock instead of wrinkled frock, and by locating truth-as-existence in stillbirth and death so ill as to be still as still can be. If truth is life and life is motion, then how can truth be motionless death? They forget that their hard iron ore once flowed molten-bright and ductile enough to be pushed by oar.

It also makes slick and seemly sense, on the sheen of the surface at least, that we’ve associated change with death and the negation of truth. What once was is no more — and change is the culprit. Disintegration, destruction, death and the rank rot of fetid flesh all use change as their conduit. What they’ve failed to see is that so too with life, which acts solely through change. They’ve mistaken upheaval for removal, forgetting that to be we heave by the second as we breathe unbeckoned. Death only seems to require change because it’s still life until the very end. Life is change, life is motion, and death, when finally finished, is just the opposite.

In any case, they are wrong. Life doesn’t need limitation to get its hard-sought legitimation. Life is its own baseline and reference point. Death is a negation of life, taking all and leaving but the forsaken debris strewn by your wakeup quake.

High-Digger’s Being is Time Timing Itself

Another version of the “limiting factor” argument comes from Martin Heidegger, in his massive philosophical work Being and Time.

In the section being-toward-death he claims, on one level, that Being must be a totality, and in order to be a totality (in the sense of absolute or not containing anything outside of itself) it must also be that which it is not. Being can only become what it is not through death and so in order for Being to become a totality (which he argues it must in order to achieve authenticity – which is the goal all along, after all) it must become what it is not — that is, death — for completion. This reinforces some interpretations made above in linking truth with completion and completion with staticity.

Another line of reasoning taken by Heidegger seems to reinforce the interpretation made by Cooney, which was probably influenced heavily by Heidegger’s concept of being-toward-death. The “fact” that we will one day die causes Being to reevaluate itself, realize that it is time and time is finite, and that its finitude requires it to take charge of its own life — to find authenticity. Finitude for Heidegger legitimizes our freedom. If we had all the time in the world to become authentic, then what’s the point? It can always be deferred. But if our time is finite then the choice of whether to achieve authenticity or not falls in our own hands. Since we must make choices on how to spend our time, failing and to become authentic by spending one’s time on actions that don’t help achieve authenticity becomes our fault.

To be philosophically scrupulous would involve dissecting Heidegger’s mammoth Being and Time, and that is beyond the scope of this essay. Anyone who thinks I’ve misinterpreted Heidegger, or who thinks that Heidegger’s concept of Being-Towards-Death warrants a fuller explication that what it’s been given here, is encouraged to comment.

Can Limitless Life still have a “Filling Stillness” and “Legitimizing Li’mit”?

Perhaps more importantly, even if their premises were correct (i.e. that the “change” of death adds some baseline limiting factor, causing you to do what you would have not if you had all the time in the world, and thereby constituting our main motivator for motion and metric for meaning) they are still wrong in the conclusion that indefinitely-extended life would destroy or jeopardize this “essential limitation”.

The crux of the “death-gives-meaning-to-life” argument is that life needs scarcity, finitude or some other factor restricting the possible choices that could be made, in order to find meaning. But final death need not be the sole candidate for such a restricting factor.

Self: Le Petite Mort

All changed, changed utterly… A terrible beauty is born. The self sways by the second. We are creatures of change, and in order to live we die by the moment. I am not the same as I once was, and may never be the same again. The choices we prefer and the decisions we are most likely to make go through massive upheaval.

The changing self could constitute this “scarcitizing” or limiting factor just as well as death could. We can be compelled to prioritize certain choices and actions over others because we might be compelled to choose differently in another year, month or day. We never know what we will become, and this is a blessing. Life itself can act as the limiting factor that, for some, legitimizes life.

Society: Le Petite Fin Du Monde

Society is ever on an s-curve swerve of consistent change as well. Culture is in constant upheaval, with new opportunity’s opening upward all the time. Thus the changing state of culture and humanity’s upheaved hump through time could act as this “limiting factor” just as well as death or the changing self could. What is available today may be gone tomorrow. We’ve missed our chance to see the Roman Empire at its highest point, to witness the first Moon landing, to pioneer a new idea now old. Opportunities appear and vanish all the time.

Indeed, these last two points – that the changing state of self and society, together or singly, could constitute such a limiting factor just as effectively as death could – serve to undermine another common argument against the desirability of limitless life (boredom) – thereby killing two inverted phoenixes with one stoning. Too often is this rather baseless claim bandied about as a reason to forestall RLE – that longer life will lead to increased boredom. That self and society are in a constant state of change means that boredom should become increasingly harder to maintain. We are on the verge of our umpteenth rebirth, and the modalities of being that are set to become available to us, as selves and as societies, will ensure that the only way to entertain the notion of increased boredom will be to personally hard-wire it into ourselves.

Life gives meaning to life, dummy!

Death is nothing but misplaced waste, and I think it’s time to take out the trash, with haste. We don’t need death to make certain opportunities more pressing than others, or to allow us to assign higher priorities to one action than we do to another. The change underlying life’s self-overcoming will do just fine, thank you.

This article was originally published by Transhumanity

It is often said that empiricism is one of the most useful concepts in epistemology. Empiricism emphasises the role of experience acquired through one’s own senses and perceptions, and is contrary to, say, idealism where concepts are not derived from experience, but based on ideals.

In the case of radical life extension, there is a tendency to an ‘idealistic trance’ where people blindly expect practical biotechnological developments to be available and applied to the public at large within a few years. More importantly, idealists expect these treatments or therapies to actually be effective and to have a direct and measurable effect upon radical life extension. Here, by ‘radical life extension’ I refer not to healthy longevity (a healthy life until the age of 100–120 years) but to an indefinite lifespan where the rate of age-related mortality is trivial.

Let me mention two empirical examples based on experience and facts:

1. When a technological development depends on technology alone, its progress is often dramatic and exponential.

2. When a technological development also depends on biology, its progress is embarrassingly negligible.

Developments based solely on mechanical, digital or electronic concepts are proliferating freely and vigorously. Just 20 years ago, almost nobody had a mobile telephone or knew about the internet. Now we have instant global communication accessible by any member of the general public.

Contrast this with the advancement of biotechnology with regards to, say, the treatment of the common cold. There has not been a significantly effective treatment for the public at large for, I will not say a million, but certainly for several thousand years. The accepted current medical treatment for the common cold is with bed rest, fluids, and antipyretics which is the same as that suggested by Hippocrates. Formal guidelines for the modern treatment of cardiac arrest include chest compressions and mouth- to- mouth resuscitation (essentially the same as the technique used by the prophet Elisha in the Old Testament) as well as intra-cardiac (!) atropine, lignocaine and other drugs used by physicians during the 1930’s. In my medical museum in Cyprus (http://en.wikipedia.org/wiki/Kyriazis_Medical_Museum) I have examples of Medieval treatments for urinary retention (it was via a metal urinary catheter then, whereas now the catheter is plastic), treatment of asthma (with belladonna then, ipratropium now – a direct derivative), and treatment of pain (with opium then, with opium-like derivatives now).

About a hundred years ago, my grandfather (http://en.wikipedia.org/wiki/Neoklis_Kyriazis) wrote a book on hygiene, longevity and healthy life for the public, which included advice such as fresh air, exercise, consumption of fruit and vegetables, avoidance of excessive alcohol or cigarette smoke. These are of course preventative treatments advised by modern anti-ageing practitioners, hardly any progress in a century. In fact, these are the only proven treatments. Even the modern notion of ‘antioxidants’ can be encountered as standard health advice in medical books from the 1800’s. With the trivial exception of a handful of other examples, there has hardly been any progress in healthy longevity at all that can be applied to the common man in the street. Resveratrol? Was a standard health advice in ancient Greek medicine (red wine). Carnosine? Discovered and used 100 years ago. Cycloastragenol? Used in Chinese medicine 1000 years ago.

My question is: how do we expect to influence the process of ageing when we cannot even develop bio-technological cures for simple and common diseases? Are we really serious when we talk about biotechnological treatments that can lead to radical life extension, being developed within the next few years? And if we are really serious, is this belief based on empiricism or idealism? The manipulation of human biology has been particularly tricky, with no significant progress of effective breakthroughs developed during the past several decades. Here I, of course, acknowledge the value of some modern drugs and isolated bio-technological achievements, but my point is that these developments are based on relatively minor refinements of existing therapies, and not on new breakthroughs that can modify the human body in any positive or practical degree. Importantly, even if some isolated examples of effective biotechnology do exist, these are not yet suitable for use by the general public at large.

If we were to compare the progress of general technology with that of life extension biotechnology, we could see that:

A. The progress of technology over the past 100 years has been logarithmic to exponential, whereas that of life extension biotechnology has been virtually static.

B. The progress of technology over the past 20 years has been exponential, whereas that of life extension biotechnology has barely been logarithmic.

It is one thing to talk about future biotechnology developments as a discussion point, and to post these in blogs, for general curiosity. But it is a different thing altogether if we actually want to devise and deliver an effective, practical therapy that truly affords significant life extension.

A different approach is needed, one that does not depend exclusively on biotechnology. It would be naïve to say that I am arguing for the total abandonment of life extension biotechnology, but it is equally naïve to believe that this biotechnology is likely to be effective on its own. A possible way forward could be the attempt to modify human biology not via biotechnology alone, but also by making use of natural, already existing evolutionary mechanisms. One such example could be the use of ‘information-that-requires-action’ in order to force a reallocation of resources from germ-line to somatic cells. This is an approach we currently aiming to describe in detail. My final remark with regards to achieving indefinite lifespan is this: we must engage with technology without depending on biotechnology.

For some general background information on how to engage with technology see:

http://hplusmagazine.com/2012/12/06/the-longevity-of-real-human-avatars/

http://hplusmagazine.com/2011/03/04/indefinite-lifespans-a-n…bal-brain/

http://ieet.org/index.php/IEET/more/kyriazis20121031